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Patent Agency Ranking
公开(公告)号：WO2011153514A2
公开(公告)日：2011-12-08
申请号：PCT/US2011/039190
申请日：2011-06-03
Applicant: PHARMACYCLICS, INC. , BUGGY, Joseph, J. , ELIAS, Laurence , FYFE, Gwen , HEDRICK, Eric , LOURY, David, J. , MODY, Tarak, D.
Inventor： BUGGY, Joseph, J. , ELIAS, Laurence , FYFE, Gwen , HEDRICK, Eric , LOURY, David, J. , MODY, Tarak, D.
IPC: A61K31/519 , A61K31/505 , A61P35/02 , A61P35/00
CPC classification number: A61K31/519 , A61K9/0014 , A61K9/0031 , A61K9/0048 , A61K9/0056 , A61K9/007 , A61K9/06 , A61K31/195 , A61K31/337 , A61K31/4184 , A61K31/436 , A61K31/437 , A61K31/454 , A61K31/4745 , A61K31/475 , A61K31/573 , A61K31/606 , A61K31/664 , A61K31/675 , A61K31/69 , A61K31/7032 , A61K31/704 , A61K31/7076 , A61K39/395 , A61K39/39533 , A61K39/3955 , A61K45/06 , C07D487/04 , A61K2300/00
Abstract: Disclosed herein are methods for treating a cancer comprising: a. administering a Btk inhibitor to a subject sufficient to result in an increase or appearance in the blood of a subpopulation of lymphocytes defined by immunophenotyping; b. determining the expression profile of one or more biomarkers from one or more subpopulation of lymphocytes; and c. administering a second agent based on the determined expression profile.
Abstract translation: 本文公开了治疗癌症的方法，包括：a。 对受试者施用Btk抑制剂足以导致免疫表型定义的淋巴细胞亚群的血液增加或出现; 湾 确定来自一个或多个淋巴细胞亚群的一种或多种生物标志物的表达谱; 和c。 基于所确定的表达谱来施用第二试剂。
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公开(公告)号：WO2013059738A2
公开(公告)日：2013-04-25
申请号：PCT/US2012/061208
申请日：2012-10-19
Applicant: PHARMACYCLICS, INC.
Inventor： BUGGY, Joseph J. , ELIAS, Laurence , FYFE, Gwen , HEDRICK, Eric , LOURY, David J. , MODY, Tarak D.
IPC: A61K31/52 , A61K31/519 , A61P35/00
CPC classification number: A61K31/519 , A61K31/337 , A61K31/4184 , A61K31/454 , A61K31/475 , A61K31/4965 , A61K31/52 , A61K31/5383 , A61K31/704 , A61K31/7076 , A61K45/06 , C12Q1/6886 , G01N33/57484 , A61K2300/00
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公开(公告)号：WO2015023703A1
公开(公告)日：2015-02-19
申请号：PCT/US2014/050783
申请日：2014-08-12
Applicant: PHARMACYCLICS, INC. , CHEN, Jun , BUGGY, Joseph, J. , ELIAS, Laurence
Inventor： CHEN, Jun , BUGGY, Joseph, J. , ELIAS, Laurence
IPC: A61K31/4162 , A61K31/4155 , A61K31/519 , A61K31/506 , A61P35/00
CPC classification number: A61K31/519 , A61K31/454 , A61K45/06
Abstract: Described herein are methods and compositions for treating HER2-amplified cancer. The methods include administering to an individual in need thereof ibrutinib.
Abstract translation: 本文描述了用于治疗HER2扩增的癌症的方法和组合物。 所述方法包括向有需要的个体施用伊布他尼。
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公开(公告)号：EP2575818A2
公开(公告)日：2013-04-10
申请号：EP11790524.0
申请日：2011-06-03
Applicant: Pharmacyclics, Inc.
Inventor： BUGGY, Joseph, J. , ELIAS, Laurence , FYFE, Gwen , HEDRICK, Eric , LOURY, David, J. , MODY, Tarak, D.
IPC: A61K31/519 , A61K31/505 , A61P35/02 , A61P35/00
CPC classification number: A61K31/519 , A61K9/0014 , A61K9/0031 , A61K9/0048 , A61K9/0056 , A61K9/007 , A61K9/06 , A61K31/195 , A61K31/337 , A61K31/4184 , A61K31/436 , A61K31/437 , A61K31/454 , A61K31/4745 , A61K31/475 , A61K31/573 , A61K31/606 , A61K31/664 , A61K31/675 , A61K31/69 , A61K31/7032 , A61K31/704 , A61K31/7076 , A61K39/395 , A61K39/39533 , A61K39/3955 , A61K45/06 , C07D487/04 , A61K2300/00
Abstract: Disclosed herein are methods for treating a cancer comprising: a. administering a Btk inhibitor to a subject sufficient to result in an increase or appearance in the blood of a subpopulation of lymphocytes defined by immunophenotyping; b. determining the expression profile of one or more biomarkers from one or more subpopulation of lymphocytes; and c. administering a second agent based on the determined expression profile.
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公开(公告)号：EP2771010A2
公开(公告)日：2014-09-03
申请号：EP12841068.5
申请日：2012-10-19
Applicant: Pharmacyclics, Inc.
Inventor： BUGGY, Joseph J. , ELIAS, Laurence , FYFE, Gwen , HEDRICK, Eric , LOURY, David J. , MODY, Tarak D.
IPC: A61K31/52 , A61K31/519 , A61P35/00
CPC classification number: A61K31/519 , A61K31/337 , A61K31/4184 , A61K31/454 , A61K31/475 , A61K31/4965 , A61K31/52 , A61K31/5383 , A61K31/704 , A61K31/7076 , A61K45/06 , C12Q1/6886 , G01N33/57484 , A61K2300/00
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