公开(公告)号：US20140080879A1

公开(公告)日：2014-03-20

申请号：US13623578

申请日：2012-09-20

Applicant: PHARMACYCLICS, INC.

Inventor： Daniel A. Dickman ,  Dange Vijay Kumar ,  Colin O'Bryan ,  Roopa Rai ,  William Dvorak Shrader

IPC: A61K31/4184 ,  A61P7/02 ,  C07D235/18

CPC classification number: C07F5/025 ,  C07D235/18

Abstract: The present invention relates to novel inhibitors of Factors VIIa, IXa, Xa, XIa, in particular Factor VIIa, pharmaceutical compositions comprising these inhibitors, and methods for using these inhibitors for treating or preventing thromboembolic disorders, cancer or rheumatoid arthritis. Processes for preparing these inhibitors are also disclosed.

Abstract translation: 本发明涉及因子VIIa，IXa，Xa，XIa，特别是因子VIIa的新型抑制剂，包含这些抑制剂的药物组合物，以及使用这些抑制剂治疗或预防血栓栓塞性疾病，癌症或类风湿性关节炎的方法。 还公开了制备这些抑制剂的方法。

公开(公告)号：US08729117B2

公开(公告)日：2014-05-20

申请号：US13623578

申请日：2012-09-20

Applicant: Pharmacyclics, Inc.

Inventor： Daniel A. Dickman ,  Dange Vijay Kumar ,  Colin O'Bryan ,  Roopa Rai ,  William Dvorak Shrader

IPC: C07D235/04

CPC classification number: C07F5/025 ,  C07D235/18

Abstract: The present invention relates to novel inhibitors of Factors VIIa, IXa, Xa, XIa, in particular Factor VIIa, pharmaceutical compositions comprising these inhibitors, and methods for using these inhibitors for treating or preventing thromboembolic disorders, cancer or rheumatoid arthritis. Processes for preparing these inhibitors are also disclosed.

Abstract translation: 本发明涉及因子VIIa，IXa，Xa，XIa，特别是因子VIIa的新型抑制剂，包含这些抑制剂的药物组合物，以及使用这些抑制剂治疗或预防血栓栓塞性疾病，癌症或类风湿性关节炎的方法。 还公开了制备这些抑制剂的方法。