公开(公告)号：WO2007087068A3

公开(公告)日：2008-02-21

申请号：PCT/US2006049489

申请日：2006-12-28

Applicant: PHARMACYCLICS INC ,  JANKOWSKI ORION D ,  PALMER JAMES T ,  HONIGBERG LEE

Inventor： JANKOWSKI ORION D ,  PALMER JAMES T ,  HONIGBERG LEE

IPC: C07D471/06 ,  A61K31/416 ,  A61K31/4375 ,  A61K31/675

CPC classification number: C07D471/04 ,  C07F9/65685 ,  C07F9/65846

Abstract: Disclosed herein are compounds that inhibit the activity of particular tyrosine kinases. Methods for the preparation of such compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the compounds disclosed, alone or in combination with other therapeutic agents, for the treatment of tyrosine kinase-rnediated diseases or conditions or tyrosine, kinase-dependent diseases or conditions are provided.

Abstract translation: 本文公开了抑制特定酪氨酸激酶活性的化合物。 公开了制备这些化合物的方法。 还公开了包含化合物的药物组合物。 提供了将单独或与其它治疗剂组合公开的化合物用于治疗酪氨酸激酶受体疾病或病症或酪氨酸，激酶依赖性疾病或病症的方法。

公开(公告)号：EP1981888A4

公开(公告)日：2010-10-13

申请号：EP06850386

申请日：2006-12-28

Applicant: PHARMACYCLICS INC

Inventor： JANKOWSKI ORION D ,  PALMER JAMES T ,  HONIGBERG LEE

IPC: C07D471/06 ,  A61K31/416 ,  A61K31/4375 ,  A61K31/675

CPC classification number: C07D471/04 ,  C07F9/65685 ,  C07F9/65846

公开(公告)号：MX2008008642A

公开(公告)日：2008-09-12

申请号：MX2008008642

申请日：2006-12-28

Applicant: PHARMACYCLICS INC

Inventor： JANKOWSKI ORION D ,  PALMER JAMES T ,  HONIGBERG LEE

IPC: A61K31/416 ,  C07D471/06 ,  A61K31/4375 ,  A61K31/675

Abstract: Se describe en la presente compuestos que inhiben la actividad de tirosina cinasas particulares. Se describen métodos para la preparación de tales compuestos. También se describen composiciones farmacéuticas que incluyen los compuestos. Se proporcionan métodos para utilizar los compuestos descritos, solos o en combinación con otros agentes terapéuticos, para el tratamiento de enfermedades o condiciones mediadas por tirosina cinasas o enfermedades o condiciones dependientes de tirosina, cinasa.

公开(公告)号：CA2636696A1

公开(公告)日：2007-08-02

申请号：CA2636696

申请日：2006-12-28

Applicant: PHARMACYCLICS INC

Inventor： JANKOWSKI ORION D ,  PALMER JAMES T ,  HONIGBERG LEE

IPC: C07D471/06 ,  A61K31/416 ,  A61K31/4375 ,  A61K31/675

Abstract: Disclosed herein are compounds that inhibit the activity of particular tyrosine kinases. Methods for the preparation of such compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the compounds disclosed, alone or in combination with other therapeutic agents, for the treatment of tyrosine kinase-mediated diseases or conditions or tyrosine kinase-dependent diseases or conditions are provided.

公开(公告)号：AU2006336506A1

公开(公告)日：2007-08-02

申请号：AU2006336506

申请日：2006-12-28

Applicant: PHARMACYCLICS INC

Inventor： PALMER JAMES T ,  HONIGBERG LEE ,  JANKOWSKI ORION D

IPC: C07D471/06 ,  A61K31/416 ,  A61K31/4375 ,  A61K31/675

Abstract: Disclosed herein are compounds that inhibit the activity of particular tyrosine kinases. Methods for the preparation of such compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the compounds disclosed, alone or in combination with other therapeutic agents, for the treatment of tyrosine kinase-mediated diseases or conditions or tyrosine kinase-dependent diseases or conditions are provided.

公开(公告)号：BRPI0621027A2

公开(公告)日：2011-11-29

申请号：BRPI0621027

申请日：2006-12-28

Applicant: PHARMACYCLICS INC

Inventor： JANKOWSKI ORION D ,  PALMER JAMES T ,  HONIGBERG LEE

IPC: C07D471/06 ,  A61K31/416 ,  A61K31/4375 ,  A61K31/675

Abstract: Disclosed herein are compounds that inhibit the activity of particular tyrosine kinases. Methods for the preparation of such compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the compounds disclosed, alone or in combination with other therapeutic agents, for the treatment of tyrosine kinase-mediated diseases or conditions or tyrosine kinase-dependent diseases or conditions are provided.