公开(公告)号：WO2016044774A1

公开(公告)日：2016-03-24

申请号：PCT/US2015/051034

申请日：2015-09-18

Applicant: PHARMACYCLICS LLC

Inventor： NATARAJAN, Gayathri ,  SATOSKAR, Abhay R. ,  TERRAZAS, Cesar

IPC: A61K31/519

CPC classification number: A61K31/519

Abstract: Disclosed herein are methods, compounds, and kits comprising a BTK inhibitor for promoting dendritic cell maturation in a subject having cancer. Disclosed herein, in certain embodiments, is a pharmaceutical composition comprising an effective amount of a BTK inhibitor for promoting Th17 cell differentiation in a subject having cancer. In some embodiments, the Th17 cell differentiation leads to secretion of Th17 associated cytokines. In some embodiments, the Th17 associated cytokines include IL17A, IL17F, IL21, and IL22.

Abstract translation: 本文公开了包含用于在具有癌症的受试者中促进树突状细胞成熟的BTK抑制剂的方法，化合物和试剂盒。 在某些实施方案中，本文公开了包含有效量的用于在具有癌症的受试者中Th17细胞分化的BTK抑制剂的药物组合物。 在一些实施方案中，Th17细胞分化导致Th17相关细胞因子的分泌。 在一些实施方案中，Th17相关细胞因子包括IL17A，IL17F，IL21和IL22。