公开(公告)号：DE69632302T2

公开(公告)日：2005-06-23

申请号：DE69632302

申请日：1996-07-11

Applicant: PHILIPS INTELLECTUAL PROPERTY

Inventor： BOERNERT PETER ,  SCHAEFFTER TOBIAS ,  KUHN HARALD

IPC: G01R33/48 ,  A61B5/055 ,  G01R33/483 ,  G01R33/54

Abstract: A magnetic resonance method for imaging a curved portion of a body in which only MR signals in the curved portion of the body are generated by pulse sequences which include RF pulses and temporary magnetic fields. From the received MR signals an image of the curved portion can be reconstructed by use of linear transformations.\!

公开(公告)号：DE10220295A1

公开(公告)日：2003-11-20

申请号：DE10220295

申请日：2002-05-07

Applicant: PHILIPS INTELLECTUAL PROPERTY

Inventor： GRAESLIN INGMAR ,  SCHAEFFTER TOBIAS

IPC: A61B6/03 ,  A61B5/055 ,  G06T1/00 ,  G06T5/00 ,  G06T5/50

Abstract: The invention relates to a method for the processing of a series of raw images ( 1 ), notably for coronary MR or CT angiography. A reference image ( 3 ) is selected from the series of raw images ( 1 ) is found by matching a selected image region of interest within the reference image ( 3 ) with individual raw images from the series of raw images ( 1 ). The reference image ( 3 ) and the image ( 4 ) which is similar to the reference image are then processed so as to form an image of improved image quality ( 8 ). In order to obtain images which are as faithful and sharp as possible, the invention proposes to form the image of improved image quality ( 8 ) by weighted averaging of the intensity values of corresponding pixels within the reference image ( 3 ) and the image ( 4 ) which is similar to the reference image.

公开(公告)号：DE50110487D1

公开(公告)日：2006-08-31

申请号：DE50110487

申请日：2001-10-16

Applicant: PHILIPS INTELLECTUAL PROPERTY

Inventor： SCHAEFFTER TOBIAS ,  KOKEN PETER

IPC: G01R33/48 ,  G01R33/561 ,  A61B5/055 ,  G01R33/565

Abstract: The invention relates to an MR imaging method, notably for real-time imaging, in which the phase errors that occur in the MR signals because of inter alia eddy currents, are continuously monitored on the basis of the MR data sets acquired for imaging. To this end, MR signals that are successively acquired with different read-out gradients are related to one another in order to detect changes in the eddy current behavior on the basis of the phase differences. If necessary, calibration measurements are initiated so as to determine phase correction profiles whereby the phase errors of the MR data sets are compensated. For the imaging in accordance with the invention use can be made of Echo Planar Imaging (EPI) sequences for which individual, successively acquired echo signals are related to one another in order to monitor the phase errors. These echo signals are measured with the same phase encoding and with each time opposed read-out gradients for this purpose.

公开(公告)号：DE69632302D1

公开(公告)日：2004-06-03

申请号：DE69632302

申请日：1996-07-11

Applicant: PHILIPS INTELLECTUAL PROPERTY

Inventor： BOERNERT PETER ,  SCHAEFFTER TOBIAS ,  KUHN HARALD

IPC: G01R33/48 ,  A61B5/055 ,  G01R33/483 ,  G01R33/54

Abstract: A magnetic resonance method for imaging a curved portion of a body in which only MR signals in the curved portion of the body are generated by pulse sequences which include RF pulses and temporary magnetic fields. From the received MR signals an image of the curved portion can be reconstructed by use of linear transformations.\!

公开(公告)号：DE10219528A1

公开(公告)日：2003-11-13

申请号：DE10219528

申请日：2002-05-02

Applicant: PHILIPS INTELLECTUAL PROPERTY

Inventor： SCHAEFFTER TOBIAS

IPC: A61B5/055 ,  G01R33/561 ,  G01R33/58 ,  G01R33/56

Abstract: The invention relates to a magnetic resonance imaging method in which gradient echo signals (E 1 , E 2 , E 3 ) are repeatedly acquired for a plurality of phase encoding values. In order to reduce the RF load whereto a patient to be examined is exposed, the flip angles of RF excitation pulses (HF 1 , HF 2 , HF 3 , HF 4 ) of the pulse sequence are varied in dependence on the phase encoding value. For optimization of the image contrast it is advantageous when the flip angle is maximum for minimum absolute phase encoding values and minimum for maximum absolute phase encoding values.

公开(公告)号：WO2007113721A3

公开(公告)日：2009-02-19

申请号：PCT/IB2007051013

申请日：2007-03-22

Applicant: KONINKL PHILIPS ELECTRONICS NV ,  PHILIPS INTELLECTUAL PROPERTY ,  LIU WEI ,  DAHNKE HANNES ,  SCHAEFFTER TOBIAS

Inventor： LIU WEI ,  DAHNKE HANNES ,  SCHAEFFTER TOBIAS

IPC: A61K49/18 ,  A61B5/055 ,  G01R33/54

CPC classification number: A61K49/1896 ,  A61K49/1866 ,  B82Y5/00

Abstract: The present disclosure is directed to a new technique for MR measurement of ultrashort T2 * relaxation utilizing spin-echo acquisition. The ultrashort T2 * relaxometry can be used for the quantification of highly concentrated iron labeled cells in cell trafficking and therapy. In an exemplary embodiment, a signal is induced by a low flip angle RF pulse. Following excitation pulse, a gradient readout is applied to form an echo. The time between the RF pulse and the center of the gradient readout is defined as TE. In tissues with highly concentrated iron labeled cells, T2 * could be below 1 millisecond. Therefore, the signal can be decayed to a noise level with an echo time of a couple milliseconds. Because T2 * is much longer in SPIO labeled cells, the signal acquired by spin echo is much bigger than that from the gradient echo, thus avoiding the negative effects associated with the massive signal loss in the image. The ultrashort T2 * relaxation map can then by overlaid on the regular T2 * map to generate the final T2 * map of the field of view.

Abstract translation: 本公开涉及一种利用自旋回波采集的超短T2 *弛豫的MR测量的新技术。 超短T2 *松弛测定可用于定量细胞运输和治疗中高度浓缩的铁标记细胞。 在示例性实施例中，信号由低翻转RF脉冲引起。 在激发脉冲之后，应用梯度读数以形成回波。 RF脉冲与梯度读数中心之间的时间定义为TE。 在具有高浓度铁标记细胞的组织中，T2 *可能低于1毫秒。 因此，信号可以衰减到具有几毫秒的回波时间的噪声水平。 因为T2 *在SPIO标记的细胞中长得多，所以通过自旋回波获取的信号比梯度回波的信号大得多，从而避免了与图像中的大量信号丢失相关的负面影响。 然后可以将超短T2 *弛豫图覆盖在常规T2 *图上，以产生视场的最终T2 *图。

公开(公告)号：WO2007031910A3

公开(公告)日：2007-10-18

申请号：PCT/IB2006053143

申请日：2006-09-07

Applicant: PHILIPS INTELLECTUAL PROPERTY ,  KONINKL PHILIPS ELECTRONICS NV ,  DAHNKE HANNES ,  SCHAEFFTER TOBIAS

Inventor： DAHNKE HANNES ,  SCHAEFFTER TOBIAS

IPC: A61B5/055 ,  A61B6/00 ,  A61K49/00 ,  G01R33/28 ,  G01R33/56

CPC classification number: A61B5/055 ,  A61B6/481 ,  A61K49/1818 ,  B82Y5/00 ,  G01R33/50 ,  G01R33/5601 ,  G01R33/56366

Abstract: MRI based molecular imaging is strongly supported by the accurate quantification of contrast agents. According to an exemplary embodiment of the present invention, contrast agent is applied on the basis of a multiple injection application scheme, during which changes in relaxation rate are determined. This may provide for an accurate determination of tumor vascularity via MRI relaxometry.

Abstract translation: 通过造影剂的准确定量强烈支持基于MRI的分子成像。 根据本发明的示例性实施方案，在多次注射施用方案的基础上应用造影剂，在此期间确定松弛率的变化。 这可以通过MRI弛豫测定来准确地确定肿瘤血管。

公开(公告)号：WO2007113759A2

公开(公告)日：2007-10-11

申请号：PCT/IB2007051146

申请日：2007-03-30

Applicant: KONINKL PHILIPS ELECTRONICS NV ,  PHILIPS INTELLECTUAL PROPERTY ,  KEUPP JOCHEM ,  LAMERICHS RUDOLF M J N ,  SCHAEFFTER TOBIAS

Inventor： KEUPP JOCHEM ,  LAMERICHS RUDOLF M J N ,  SCHAEFFTER TOBIAS

IPC: G01R33/485

CPC classification number: G01R33/485

Abstract: The invention relates to a device for magnetic resonance imaging of a body (7) placed in an examination volume, the device (1) comprising means (2) for establishing a substantially homogeneous main magnetic field in the examination volume, means (3, 4, 5) for generating switched magnetic field gradients superimposed upon the main magnetic field, means (6) for radiating RF pulses towards the body (7), control means (12) for controlling the generation of the magnetic field gradients and the RF pulses, means (10) for receiving and sampling magnetic resonance signals, and reconstruction means (14) for forming MR images from the signal samples. According to the invention, the device (1) is arranged to a) generate a series of MR echo signals from a nuclear spin species having two or more spectral lines by subjecting at least a portion of the body (7) to an MR imaging pulse sequence using multiple time-encoding echo time values, b) acquire the MR echo signals for reconstructing a series of time- encoded MR images therefrom, each time-encoded MR image being associated with one of the time-encoding echo time values, c) superimpose the MR images for obtaining a final image.

Abstract translation: 本发明涉及一种用于放置在检查体积中的身体（7）的磁共振成像装置，该装置（1）包括用于在检查体积中建立基本均匀的主磁场的装置（2），装置（3,4） ，5），用于产生叠加在主磁场上的开关磁场梯度，用于向身体（7）辐射RF脉冲的装置（6），用于控制磁场梯度和RF脉冲的产生的控制装置（12） 用于接收和采样磁共振信号的装置（10），以及用于从信号样本形成MR图像的重构装置（14）。 根据本发明，设备（1）被布置成：a）通过使身体（7）的至少一部分经受MR成像脉冲，从而产生具有两条或更多条光谱线的核自旋物种的一系列MR回波信号 使用多个时间编码回波时间值的序列，b）获取用于重构一系列时间编码的MR图像的MR回波信号，每个时间编码的MR图像与时间编码回波时间值之一相关联，c） 叠加MR图像以获得最终图像。

公开(公告)号：WO2007122527A3

公开(公告)日：2008-01-10

申请号：PCT/IB2007051176

申请日：2007-04-02

Applicant: KONINKL PHILIPS ELECTRONICS NV ,  PHILIPS INTELLECTUAL PROPERTY ,  DAHNKE HANNES ,  SCHAEFFTER TOBIAS

Inventor： DAHNKE HANNES ,  SCHAEFFTER TOBIAS

IPC: G01R33/28 ,  G01R33/3875 ,  G01R33/48

CPC classification number: G01R33/286 ,  G01R33/3875 ,  G01R33/48 ,  G01R33/56536

Abstract: The invention relates to a device for magnetic resonance imaging of a body (7). The device (1) comprises means (2) for establishing a substantially homogeneous main magnetic field in the examination volume, means (3, 4, 5) for generating switched magnetic field gradients superimposed upon the main magnetic field, means (6) for radiating RF pulses towards the body (7), control means (12) for controlling the generation of the magnetic field gradients and the RF pulses, means (10) for receiving and sampling magnetic resonance signals, and reconstruction means (14) for forming MR images from the signal samples. In accordance with the invention, the device is arranged to a) generate a series of MR echo signals (20) by subjecting at least a portion of the body (7) to an MR imaging sequence of RF pulses and switched magnetic field gradients, b) acquire the MR echo signals for reconstructing an MR image data set (21) therefrom, c) calculate a gradient map (22) by computing echo shift parameters (SP x , SP y , SP z ) from subsets of the MR image data set, the echo shift parameters (SP x , SP y , SP z ) indicating magnetic field gradient induced shifts of the echo positions in k-space, wherein each subset comprises a number (n) of spatially adjacent pixel or voxel values of the MR image data set (21).

Abstract translation: 本发明涉及一种用于身体（7）的磁共振成像的装置。 装置（1）包括用于在检查体积中建立基本均匀的主磁场的装置（2），用于产生叠加在主磁场上的开关磁场梯度的装置（3,4,5），用于辐射的装置（6） 朝向身体的射频脉冲（7），用于控制磁场梯度和RF脉冲的产生的控制装置（12），用于接收和采样磁共振信号的装置（10）和用于形成MR图像的重构装置（14） 从信号样本。 根据本发明，该装置被设置成：a）通过使身体（7）的至少一部分经受RF脉冲和切换的磁场梯度的MR成像序列来产生一系列MR回波信号（20），b 获取用于重构MR图像数据集（21）的MR回波信号，c）通过计算回波移位参数（SP＆lt; x＆gt;，SP＆gt; 回波移位参数（SP＆lt; SUB＆gt;，SP＆lt; SUB＆gt;，SP＆lt; SUB＆gt; 指示磁场梯度引起k空间中的回波位置的移位，其中每个子集包括MR图像数据集（21）的空间相邻像素的数量（n）或体素值。

公开(公告)号：WO2007015190A3

公开(公告)日：2007-08-30

申请号：PCT/IB2006052543

申请日：2006-07-25

Applicant: PHILIPS INTELLECTUAL PROPERTY ,  KONINKL PHILIPS ELECTRONICS NV ,  NIELSEN TIM ,  VAN STEVENDAAL UDO ,  GLEICH BERNHARD ,  SCHAEFFTER TOBIAS ,  HAAKER PAUL ,  MAZURKEWITZ PETER ,  WEISS STEFFEN

Inventor： NIELSEN TIM ,  VAN STEVENDAAL UDO ,  GLEICH BERNHARD ,  SCHAEFFTER TOBIAS ,  HAAKER PAUL ,  MAZURKEWITZ PETER ,  WEISS STEFFEN

IPC: A61B5/00 ,  A61B5/05

CPC classification number: A61B5/0059 ,  A61B5/05

Abstract: An optical imaging apparatus (100) for examination of an object of interest (101), the optical imaging apparatus (100) comprising an optical radiation source (102) adapted to emit a primary optical radiation beam onto the object of interest (101), an optical radiation detector (106) adapted to detect a secondary optical radiation beam emitted by the object of interest (101) upon absorbing the primary optical radiation beam, a magnetic field generating element (107) adapted to generate an inhomogeneous magnetic field varying along an extension of the object of interest (101), and a determination unit (108) adapted to determine information concerning the object of interest (101) based on an analysis of the detected secondary optical radiation beam in combination with an analysis of the inhomogeneous magnetic field.

Abstract translation: 一种用于检查感兴趣物体（101）的光学成像设备（100），所述光学成像设备（100）包括适于将主要光学辐射束发射到感兴趣对象（101）上的光学辐射源（102） 适于在吸收主光辐射束时检测由感兴趣物体（101）发射的次级光辐射束的光学辐射检测器（106），适于产生沿着所述第一光辐射束变化的非均匀磁场的磁场产生元件（107） 感兴趣对象的扩展（101），以及确定单元（108），其适于基于对所检测到的次级光辐射束的分析来确定与感兴趣对象（101）有关的信息，以及非均匀磁场的分析 。