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公开(公告)号：WO0077491A3
公开(公告)日：2002-10-24
申请号：PCT/CA0000690
申请日：2000-06-09
Applicant: PHOTONICS RES ONTARIO
Inventor： LILGE LOTHAR , WALSH DAVID
CPC classification number: G01N21/7703 , A61N5/0601 , A61N5/062 , G01N21/6428 , G01N2201/0846 , G01N2201/088
Abstract: A multitasking optical fiber probe (10) for collecting dosimeter information from more than one position in a sample. The basic principle of the present invention involves using one or more different sensor zones (20,22,24,26,28,30) along the length of the fiber (14) each with a different photoactive constituent having a sufficiently unique emission spectra (spectral or temporal) to enable deconvolution of the emission spectra by the computer (46) and therefore correlation of the detected parameter with the position of the sensor zone along the length of the optical fiber. In the broadest form of the invention the probe is embodied by only one sensor zone located at some point along the length of the fiber spaced away from the end face of the fiber. More than one different photoactive constituent could be incorporated into a single sensor zone for measuring several factors in the vicinity of the sensor zone.
Abstract translation: 一种用于从样品中的多于一个位置收集剂量计量信息的多任务光纤探针（10）。 本发明的基本原理涉及沿着纤维（14）的长度使用一个或多个不同的传感器区域（20,22,24,26,28,30），每个具有不同的光活性成分具有足够独特的发射光谱 光谱或时间），以使得计算机（46）能够对发射光谱进行去卷积，因此检测参数与传感器区域沿着光纤长度的位置的相关性。 在本发明的最广泛形式中，探针仅通过位于沿纤维长度的某一点处的一个传感器区域，该距离与纤维的端面间隔开。 可以将多于一种不同的光活性成分结合到单个传感器区域中，以测量传感器区域附近的几个因素。
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公开(公告)号：CA2376480A1
公开(公告)日：2000-12-21
申请号：CA2376480
申请日：2000-06-09
Applicant: PHOTONICS RES ONTARIO
Inventor： WALSH DAVID , LILGE LOTHAR
Abstract: A multitasking optical fiber probe for collecting dosimeter information from more than one position in a sample. The basic principle of the present invention involves using one or more different sensor zones along the length of the fiber each with a different photoactive constituent having a sufficiently unique emission spectra (spectral or temporal) to enable deconvolution of the emission spectra by the computer and therefore correlation of the detected parameter with the position of the sensor zone along the length of the optical fiber. In the broadest form of the invention the probe is embodied by only one sensor zone located at some point along th e length of the fiber spaced away from the end face of the fiber. Probes are provided in which multiple sensor zones are disposed along the length of the fiber and photoactive constituentswith sufficiently unique emission spectra (intensity and/or spectral shape which convey the optical information) are used in the different sensor zones so that the different spectra can be deconvoluted so that the contributions from the various etch zones can be distinguished. More than one different photoactive constituent could be incorporated into a single sensor zone for measuring several factors in the vicinity of the sensor zone. In photodynamic therapyapplications the probe i s isotropic in response and can be employed for all light (300 to 900 nm) base d medical diagnostics and therapeutics. As an extension the probe can include photosensitiser and molecular oxygen concentrations dosimetry to be used for photodynamic therapy (PDT) treatment monitoring, dosimetry and planning utilizing a mathematical model describing tissue response to PDT.
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公开(公告)号：AU5380900A
公开(公告)日：2001-01-02
申请号：AU5380900
申请日：2000-06-09
Applicant: PHOTONICS RES ONTARIO
Inventor： LILGE LOTHAR , WALSH DAVID
Abstract: A multitasking optical fiber probe for collecting dosimeter information from more than one position in a sample. The basic principle of the present invention involves using one or more different sensor zones along the length of the fiber each with a different photoactive constituent having a sufficiently unique emission spectra (spectral or temporal) to enable deconvolution of the emission spectra by the computer and therefore correlation of the detected parameter with the position of the sensor zone along the length of the optical fiber. In the broadest form of the invention the probe is embodied by only one sensor zone located at some point along the length of the fiber spaced away from the end face of the fiber. Probes are provided in which multiple sensor zones are disposed along the length of the fiber and photoactive constituents with sufficiently unique emission spectra (intensity and/or spectral shape which convey the optical information) are used in the different sensor zones so that the different spectra can be deconvoluted so that the contributions from the various etch zones can be distinguished. More than one different photoactive constituent could be incorporated into a single sensor zone for measuring several factors in the vicinity of the sensor zone. In photodynamic therapy applications the probe is isotropic in response and can be employed for all light (300 to 900nm) based medical diagnostics and therapeutics. As an extension the probe can include photosensitiser and molecular oxygen concentrations dosimetry to be used for photodynamic therapy (PDT) treatment monitoring, dosimetry and planning utilizing a mathematical model describing tissue response to PDT.
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