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公开(公告)号：US20220098216A1
公开(公告)日：2022-03-31
申请号：US17426356
申请日：2020-03-25
Applicant: PROCOS S.P.A.
Inventor： Alberto LENA , Antonio TOPPINO , Katia MIELE , Jacopo ROLETTO , Paolo PAISSONI
IPC: C07D498/22
Abstract: A process for the preparation of midostaurin with high purity, particularly a process for the preparation of midostaurin with a content of oxidation impurities lower than 0.1% comprising the treatment of crude midostaurin or staurosporine with strong organic or inorganic acids in a water-immiscible solvent and, optionally, also with reducing silanes is described.
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