公开(公告)号：US11939342B2

公开(公告)日：2024-03-26

申请号：US17426356

申请日：2020-03-25

Applicant: PROCOS S.P.A.

Inventor： Alberto Lena ,  Antonio Toppino ,  Katia Miele ,  Jacopo Roletto ,  Paolo Paissoni

IPC: C07D498/22

CPC classification number: C07D498/22

Abstract: A process for the preparation of midostaurin with high purity, particularly a process for the preparation of midostaurin with a content of oxidation impurities lower than 0.1% comprising the treatment of crude midostaurin or staurosporine with strong organic or inorganic acids in a water-immiscible solvent and, optionally, also with reducing silanes is described.

公开(公告)号：US20220251111A1

公开(公告)日：2022-08-11

申请号：US17628578

申请日：2020-08-05

Applicant: Procos S.P.A.

Inventor： Alberto Lena ,  Matteo Baudino ,  Gabriele Prina Cerai ,  Antonio Toppino ,  Jacopo Roletto ,  Paolo Paissoni

IPC: C07D498/22

Abstract: The present invention relates to a process for the preparation of an amorphous form of midostaurin with a low content of residual organic solvent.