公开(公告)号：WO2021024202A1

公开(公告)日：2021-02-11

申请号：PCT/IB2020/057404

申请日：2020-08-05

Applicant: PROCOS S.P.A.

Inventor： LENA, Alberto ,  BAUDINO, Matteo ,  PRINA CERAI, Gabriele ,  TOPPINO, Antonio ,  ROLETTO, Jacopo ,  PAISSONI, Paolo

IPC: C07D498/22 ,  A61K31/553 ,  A61P35/00

Abstract: The present invention relates to a process for the preparation of an amorphous form of midostaurin with a low content of residual organic solvent.

公开(公告)号：WO2020200945A1

公开(公告)日：2020-10-08

申请号：PCT/EP2020/058273

申请日：2020-03-25

Applicant: PROCOS S.P.A.

Inventor： LENA, Alberto ,  TOPPINO, Antonio ,  MIELE, Katia ,  ROLETTO, Jacopo ,  PAISSONI, Paolo

IPC: C07D498/22

Abstract: A process for the preparation of midostaurin with high purity, particularly a process for the preparation of midostaurin with a content of oxidation impurities lower than 0.1% comprising the treatment of crude midostaurin or staurosporine with strong organic or inorganic acids in a water-immiscible solvent and, optionally, also with reducing silanes is described.

公开(公告)号：EP3947393A1

公开(公告)日：2022-02-09

申请号：EP20712975.0

申请日：2020-03-25

Applicant: Procos S.p.A.

Inventor： LENA, Alberto ,  TOPPINO, Antonio ,  MIELE, Katia ,  ROLETTO, Jacopo ,  PAISSONI, Paolo

IPC: C07D498/22

公开(公告)号：EP4010346A1

公开(公告)日：2022-06-15

申请号：EP20764455.0

申请日：2020-08-05

Applicant: Procos S.p.A.

Inventor： LENA, Alberto ,  BAUDINO, Matteo ,  PRINA CERAI, Gabriele ,  TOPPINO, Antonio ,  ROLETTO, Jacopo ,  PAISSONI, Paolo

IPC: C07D498/22 ,  A61K31/553 ,  A61P35/00