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公开(公告)号:US20180319747A1
公开(公告)日:2018-11-08
申请号:US15771050
申请日:2016-10-27
Applicant: PROCOS S.p.A.
Inventor: Matteo MOSSOTTI , Alessandro BAROZZA , Jacopo ROLETTO , Paolo PAISSONI
IPC: C07D213/64
CPC classification number: C07D213/64
Abstract: Disclosed is a process for the synthesis of Pirfenidone (1) from 5-methyl-2(1H)-pyridinone and chlorobenzene in the presence of a catalytic system consisting of a copper salt and an organic ligand, in the presence of a base. The process exploits the high efficiency of the catalytic system consisting of copper(I) salt and an organic ligand in the presence of an inorganic base in the N-amidation reaction of chlorobenzene, a cheap reagent also usable as solvent in this case; reaction conditions at high temperatures, at atmosphere pressure or higher, produce a reaction with good yields.