公开(公告)号：PH12015501130A1

公开(公告)日：2015-08-03

申请号：PH12015501130

申请日：2015-05-21

Applicant: PTC THERAPEUTICS INC

Inventor： CHANG-SUN LEE ,  RAMIL BAIAZITOV ,  LIANGXIAN CAO ,  DAVIS THOMAS W ,  WU DU ,  RONGGANG LIU ,  YOUNG-CHOON MOON ,  PAGET STEVEN D ,  HONGYU REN ,  NADIYA SYDORENKO ,  GERALD WILDE RICHARD

IPC: C07D239/48

Abstract: Amine substituted reverse pyrimidine compounds and forms thereof that inhibit the function and reduce the level of B-cell specific Moloney murine leukemia virus integration site 1 (Bmi-1) protein and methods for their use to inhibit Bmi-1 function and reduce the level of Bmi-1 to treat a cancer mediated by Bmi-1 are described herein.

公开(公告)号：ZA200701235B

公开(公告)日：2009-10-28

申请号：ZA200701235

申请日：2005-07-14

Applicant: PTC THERAPEUTICS INC

Inventor： SEONGWOO HWANG PETER ,  JAMES TAKASUGI ,  HONGYU REN ,  GERALD WILDE RICHARD ,  ANTHONY TURPOFF ,  ALEXANDER AREFOLOV ,  MITCHELL KARP GARY ,  GUANGMING CHEN ,  ALLEN CAMPBELL JEFFREY ,  CHRISTINE ESPIRITU ,  CONCETTA FREUND ,  ZHENGXIAN GU ,  TAKASHI KOMATSU

IPC: A61K20100101 ,  A61P20100101