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公开(公告)号：ES2734380T3
公开(公告)日：2019-12-05
申请号：ES15812260
申请日：2015-06-29
Applicant: PULSE HEALTH LLC
Inventor： KRAUSS MARTIN , MAHON MAURA , KING ANDREW , COOPER STEVE , INGLE JAMES , THOMAS GERALD , BARSIC DAVID , ANDREWS NEAL , YOUNG BRIAN , LARA JUVEN , NOLL CHARLES
Abstract: Un cartucho de análisis (14) que comprende: una porción del cuerpo principal (11) que incluye una parte superior (29) que define una cámara superior (30), y una parte inferior (31) que define una cámara de fluido (32), en donde la cámara superior (30) es una cámara de respiración que incluye una abertura de entrada de respiración (33), una abertura de salida de respiración (40) y una trayectoria de respiración entre ellas, y un conjunto de filtro (19) que se puede mover a lo largo de una trayectoria de conjunto de filtro entre una primera posición y una segunda posición, en donde el conjunto de filtro tiene una abertura definida a través del mismo, y en donde en la primera posición, la abertura define parcialmente la cámara superior y en la segunda posición la abertura define parcialmente la cámara de fluido; y un miembro de ampolla (22) que tiene un espacio de cromóforo de fluorescencia con un derivado de fenilendiamina dispuesto en el mismo, en donde la cámara de fluido incluye una solución de elución dispuesta en su interior, en donde el miembro de ampolla es móvil entre una primera posición en la que el derivado de fenilendiamina se separa de la solución de elución y una segunda posición en la que el derivado de fenilendiamina se dispone en la solución de elución.
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公开(公告)号：WO2015200926A8
公开(公告)日：2017-01-12
申请号：PCT/US2015038394
申请日：2015-06-29
Applicant: PULSE HEALTH LLC
Inventor： BARSIC DAVID , DREILINGER RACHEL , KRAUSS MARTIN , BORO JON , INGLE JAMES
IPC: C12M1/34
CPC classification number: G01N1/22 , A61B5/0071 , A61B5/082 , A61B5/087 , G01D11/24 , G01N21/6428 , G01N21/645 , G01N33/497 , G01N33/4972 , G01N33/52 , G01N33/64 , G01N2001/2244 , G01N2021/6482 , G01N2033/4975 , G01N2201/022 , G01N2201/062 , G01N2201/068 , Y10T436/200833 , Y10T436/202499
Abstract: A fluorescence detection assembly that includes an emitter, a detector, a housing that defines an light chamber, a fluorescence chamber and a well, a light path that extends from the emitter, through the light chamber and through the well, and a fluorescence path that extends from the well, through the fluorescence chamber and to the detector.
Abstract translation: 一种荧光检测组件，其包括发射器，检测器，限定光室的壳体，荧光腔和阱，从发射器延伸穿过光室并通过阱的光路，以及荧光路径， 从孔延伸通过荧光室和检测器。
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公开(公告)号：WO2015200921A3
公开(公告)日：2016-08-11
申请号：PCT/US2015038386
申请日：2015-06-29
Applicant: PULSE HEALTH LLC
Inventor： COOPER STEVE , ANDREWS NEAL , KRAUSS MARTIN , KING ANDREW E , MAHON MAURA , MYLER WESTON , INGLE JAMES , THOMAS GERALD , DREILINGER RACHEL , BARSIC DAVID , MEYERS RICK , CARLSEN CRAIG , HERBST SCOT , YOUNG BRIAN , LARA JUVEN , NOLL CHARLES
IPC: A61B5/097
CPC classification number: G01N1/22 , A61B5/0071 , A61B5/082 , A61B5/087 , G01D11/24 , G01N21/6428 , G01N21/645 , G01N33/497 , G01N33/4972 , G01N33/52 , G01N33/64 , G01N2001/2244 , G01N2021/6482 , G01N2033/4975 , G01N2201/022 , G01N2201/062 , G01N2201/068 , Y10T436/200833 , Y10T436/202499
Abstract: A breath analysis system that includes a handle assembly with an analysis cartridge on an upper end thereof. The handle includes a main body portion with a pressure opening and a pressure transducer therein. The analysis cartridge includes a main body portion with an upper portion that defines a breath chamber, a lower portion that defines a fluid chamber and a filter assembly that is movable between a breath capture position and an analysis position. The filter assembly has an opening defined therethrough. In the breath capture position, the opening partially defines the breath chamber and in the analysis position the opening partially defines the fluid chamber. The system also includes an analysis device with door, a controller that controls the motor and a fluorescence detection assembly and a rotation assembly positioned in the case interior. The rotation assembly includes a shroud with a funnel portion for receiving the analysis cartridge.
Abstract translation: 一种呼吸分析系统，其包括在其上端具有分析盒的手柄组件。 手柄包括具有压力开口的主体部分和其中的压力换能器。 分析盒包括主体部分，其具有限定呼吸室的上部，限定流体室的下部和可在呼吸捕获位置和分析位置之间移动的过滤器组件。 过滤器组件具有通过其限定的开口。 在呼吸捕获位置，开口部分地限定呼吸室，并且在分析位置中，开口部分地限定流体室。 该系统还包括具有门的分析装置，控制电动机的控制器和位于壳体内部的荧光检测组件和旋转组件。 旋转组件包括具有用于接收分析盒的漏斗部分的护罩。
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公开(公告)号：CA2953537A1
公开(公告)日：2015-12-30
申请号：CA2953537
申请日：2015-06-29
Applicant: PULSE HEALTH LLC
Inventor： KRAUSS MARTIN , MAHON MAURA , KING ANDREW E , COOPER STEVE , INGLE JAMES , THOMAS GERALD , BARSIC DAVID , ANDREWS NEAL , YOUNG BRIAN , LARA JUVEN , NOLL CHARLES
IPC: A61B10/00 , A61B5/097 , G01N1/02 , G01N1/22 , G01N33/497
Abstract: An analysis cartridge the includes a main body portion and a filter assembly. The main body portion includes an upper portion that defines an upper chamber and a lower portion that defines a fluid chamber. The filter assembly is movable along a filter assembly path between a first position and a second position. The filter assembly has an opening defined therethrough. In the first position, the opening partially defines the upper chamber and in the second position the opening partially defines the fluid chamber.
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公开(公告)号：CA2953531A1
公开(公告)日：2015-12-30
申请号：CA2953531
申请日：2015-06-29
Applicant: PULSE HEALTH LLC
Inventor： THOMAS GERALD , YOUNG BRIAN , LARA JUVEN , NOLL CHARLES , INGLE JAMES
IPC: G01N21/64
Abstract: Fluorescence chromophores such as phenylene diamine derivatives can undergo oxidative coupling and polymerization to form optical, colorimetric and fluorogenic, multimers and polymers. The presence of carbonyl containing moieties such as aldehydes and ketones under favorable environmental conditions can initiate, catalyze, accelerate and modulate this reaction which in turn provides a mechanism for the detection and quantitation of such moieties. Selected phenylene diamine derivatives can be used for the detection and quantitation of aldehyde and ketones via measurement of the reaction and the associated spectroscopic transformation. In particular, the use of meto-phenylene diamine (mPDA) and related compounds for aldehyde detection and quantitation is described. The method provides a convenient means for monitoring aldehyde and ketone levels without use of separation steps. The method is applicable to kinetic and quasi- endpoint detection assay formats.
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Patent Agency Ranking
公开(公告)号：HRP20191210T1
公开(公告)日：2019-11-01
申请号：HRP20191210
申请日：2019-07-03
Applicant: PULSE HEALTH LLC
Inventor： KRAUSS MARTIN , MAHON MAURA , KING ANDREW E , COOPER STEVE , INGLE JAMES , THOMAS GERALD , BARSIC DAVID , ANDREWS NEAL , YOUNG BRIAN , LARA JUVEN , NOLL CHARLES
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公开(公告)号：PL3160361T3
公开(公告)日：2019-10-31
申请号：PL15812260
申请日：2015-06-29
Applicant: PULSE HEALTH LLC
Inventor： KRAUSS MARTIN , MAHON MAURA , KING ANDREW E , COOPER STEVE , INGLE JAMES , THOMAS GERALD , BARSIC DAVID , ANDREWS NEAL , YOUNG BRIAN , LARA JUVEN , NOLL CHARLES
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公开(公告)号：HUE044429T2
公开(公告)日：2019-10-28
申请号：HUE15812260
申请日：2015-06-29
Applicant: PULSE HEALTH LLC
Inventor： KRAUSS MARTIN , MAHON MAURA , KING ANDREW , COOPER STEVE , INGLE JAMES , THOMAS GERALD , BARSIC DAVID , ANDREWS NEAL , YOUNG BRIAN , LARA JUVEN , NOLL CHARLES
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公开(公告)号：SI3160361T1
公开(公告)日：2019-09-30
申请号：SI201530815
申请日：2015-06-29
Applicant: PULSE HEALTH LLC
Inventor： KRAUSS MARTIN , MAHON MAURA , KING ANDREW E , COOPER STEVE , INGLE JAMES , THOMAS GERALD , BARSIC DAVID , ANDREWS NEAL , YOUNG BRIAN , LARA JUVEN , NOLL CHARLES
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公开(公告)号：AU2017378481A1
公开(公告)日：2019-07-25
申请号：AU2017378481
申请日：2017-12-15
Applicant: PULSE HEALTH LLC
Inventor： THOMAS GERALD , LARA JUVEN , YOUNG BRIAN , NOLL CHARLES , CARLSEN CRAIG , INGLE JAMES
Abstract: Systems and methods directed to aldehyde detection are disclosed. An aldehyde detection system may capture aldehydes from a patient breath sample. Aldehydes of the breath sample may be used to form a mobile chromatography phase within an analysis device. The analysis device may include various modules configured to perform a high pressure liquid chromatography process that separates aldehydes according to size. A detection assembly may detect a relative value of the separated aldehydes. The analysis device may be configured to determine an aldehyde score or metric based on the detected aldehydes, which may assist in the diagnosis of certain medical conditions.
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