公开(公告)号：US09249086B2

公开(公告)日：2016-02-02

申请号：US14419125

申请日：2013-08-02

Applicant: Photocure ASA

Inventor： Jon Erik Brænden ,  Colin Barry Charnock ,  Aslak Godal ,  Jo Klaveness ,  Nils Olav Nilsen

IPC: C07C229/24 ,  A61K41/00 ,  C07C229/22

CPC classification number: C07C229/24 ,  A61K41/0061 ,  C07C229/22

Abstract: The invention relates to new derivatives of 5-aminolevulinic acid (5-ALA) and their use as photosensitizing agents. In particular, it relates to compounds of general formula I and their pharmaceutically acceptable salts, to methods for preparing such compounds and their medical and cosmetic use, for example in methods of photodynamic therapy and diagnosis: wherein R1 represents a hydrogen atom or an optionally substituted alkyl or cycloalkyl group; R2, each of which may be the same or different, represents a hydrogen atom or an optionally substituted alkyl group; and X is a linking group.

Abstract translation: 本发明涉及5-氨基乙酰丙酸（5-ALA）的新衍生物及其作为光敏剂的用途。 具体地说，本发明涉及通式Ⅰ化合物及其药学上可接受的盐，制备这些化合物的方法及其医疗和化妆品用途，例如在光动力学治疗和诊断方法中：其中R1表示氢原子或任选取代的 烷基或环烷基; R2各自可以相同或不同，表示氢原子或任选取代的烷基; X是连接基团。

公开(公告)号：US20150191419A1

公开(公告)日：2015-07-09

申请号：US14419125

申请日：2013-08-02

Applicant: Photocure ASA

Inventor： Jon Erik Brænden ,  Colin Barry Charnock ,  Aslak Godal ,  Jo Klaveness ,  Nils Olav Nilsen

IPC: C07C229/24 ,  A61K41/00 ,  C07C229/22

CPC classification number: C07C229/24 ,  A61K41/0061 ,  C07C229/22

Abstract: The invention relates to new derivatives of 5-aminolevulinic acid (5-ALA) and their use as photosensitizing agents. In particular, it relates to compounds of general formula I and their pharmaceutically acceptable salts, to methods for preparing such compounds and their medical and cosmetic use, for example in methods of photodynamic therapy and diagnosis: wherein R1 represents a hydrogen atom or an optionally substituted alkyl or cycloalkyl group; R2, each of which may be the same or different, represents a hydrogen atom or an optionally substituted alkyl group; and X is a linking group.

Abstract translation: 本发明涉及5-氨基乙酰丙酸（5-ALA）的新衍生物及其作为光敏剂的用途。 具体地说，本发明涉及通式Ⅰ化合物及其药学上可接受的盐，制备这些化合物的方法及其医疗和化妆品用途，例如在光动力学治疗和诊断方法中：其中R1表示氢原子或任选取代的 烷基或环烷基; R2各自可以相同或不同，表示氢原子或任选取代的烷基; X是连接基团。