公开(公告)号：US20220064710A1

公开(公告)日：2022-03-03

申请号：US17464476

申请日：2021-09-01

Applicant: Promega Corporation

Inventor： Ce SHI ,  Nathan FEIRER ,  Michael SCURRIA ,  Subhanjan MONDAL ,  Said GOUELI ,  Thomas KIRKLAND ,  James J. CALI ,  Poncho MEISENHEIMER

IPC: C12Q1/686 ,  C07D221/12 ,  C07F15/00 ,  C07D403/04 ,  C07D513/06 ,  C12Q1/70 ,  C12Q1/689

Abstract: The present disclosure includes compounds, compositions, and methods for nucleic acid amplification reactions. In particular, the present disclosure provides compounds, compositions, and methods for viability PCR (vPCR) applications, in which the compounds that selectively bind to nucleic acids from non-viable cells.

公开(公告)号：US20250022022A1

公开(公告)日：2025-01-16

申请号：US18890453

申请日：2024-09-19

Applicant: Promega Corporation

Inventor： Andrew S. DIXON ,  Lance ENCELL ,  Mary HALL ,  Keith WOOD ,  Monika WOOD ,  Marie SCHWINN ,  Brock F. BINKOWSKI ,  Hicham ZEGZOUTI ,  Nidhi NATH ,  Subhanjan MONDAL ,  Said GOUELI ,  Poncho MEISENHEIMER ,  Thomas KIRKLAND ,  James UNCH ,  Dileep K. PULUKKUNAT ,  Matthew ROBERS ,  Melanie DART ,  Thomas MACHLEIDT

IPC: G06Q30/0283 ,  G06Q30/0601 ,  H04W4/02 ,  H04W4/35 ,  H04W4/38

Abstract: Provided herein are compositions and methods for the assembly of a bioluminescent complex from two or more non-luminescent (e.g., substantially non-luminescent) peptide and/or polypeptide units. In particular, bioluminescent activity is conferred upon a non-luminescent polypeptide via structural complementation with another, complementary non-luminescent peptide.

公开(公告)号：US20250045806A1

公开(公告)日：2025-02-06

申请号：US18893549

申请日：2024-09-23

Applicant: Promega Corporation

Inventor： Andrew S. DIXON ,  Lance ENCELL ,  Mary HALL ,  Keith WOOD ,  Monika WOOD ,  Marie SCHWINN ,  Brock F. BINKOWSKI ,  Hicham ZEGZOUTI ,  Nidhi NATH ,  Subhanjan MONDAL ,  Said GOUELI ,  Poncho MEISENHEIMER ,  Thomas KIRKLAND ,  James UNCH ,  Dileep K. PULUKKUNAT ,  Matthew ROBERS ,  Melanie DART ,  Thomas MACHLEIDT

IPC: G06Q30/0283 ,  G06Q30/0601 ,  H04W4/02 ,  H04W4/35 ,  H04W4/38

Abstract: Provided herein are compositions and methods for the assembly of a bioluminescent complex from two or more non-luminescent (e.g., substantially non-luminescent) peptide and/or polypeptide units. In particular, bioluminescent activity is conferred upon a non-luminescent polypeptide via structural complementation with another, complementary non-luminescent peptide.