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    Photoacoustic catheter and imaging system using same
    3.
    发明授权
    Photoacoustic catheter and imaging system using same 有权

    公开(公告)号：US11109763B2

    公开(公告)日：2021-09-07

    申请号：US15998889

    申请日：2017-02-13

    Applicant: PURDUE RESEARCH FOUNDATION

    Inventor： Ji-xin Cheng ,  Pu Wang ,  Yingchun Cao ,  Jie Hui

    IPC: A61B5/00 ,  A61B8/00 ,  A61B5/02 ,  A61B8/12 ,  A61M25/00

    Abstract: A photoacoustic catheter includes an elongated catheter body and a housing positioned near a distal end of the elongated catheter body. A length of multimode fiber extends through the elongated catheter body and has a distal end that is beveled at about 45° relative to a longitudinal axis of the multimode fiber and is positioned in the housing. An ultrasonic transducer, electrically connected to an electrical wire extending along the elongated catheter body, is positioned within the housing. A mirror element is also positioned within the housing and includes a mirror surface beveled at about 45° relative to the longitudinal axis of the multimode fiber. The catheter is operable to deliver an optical wave through the multimode fiber and to deliver an ultrasonic wave collinearly from the housing and out of an aperture of the housing to obtain optical data and ultrasonic data within a mammalian luminal organ.

    Raman Tag
    4.
    发明申请
    Raman Tag 有权
    拉曼标签

    公开(公告)号：US20160068562A1

    公开(公告)日：2016-03-10

    申请号：US14850949

    申请日：2015-09-10

    Applicant: Purdue Research Foundation

    Inventor： Ji-xin Cheng ,  Mingji Dai

    IPC: C07J9/00 ,  G01N33/52

    CPC classification number: C07J9/00 ,  C07J9/005 ,  C07J17/00 ,  C07J41/0094 ,  G01N33/52

    Abstract: The present invention provides novel Raman tags for exploring membrane interactions in cells. The tags comprise a phenyl diyne probe where in the dyine is capped with the phenyl group. Methods for using the tags are also provided.

    Abstract translation: 本发明提供用于探索细胞中膜相互作用的新型拉曼标签。 标签包括苯基二炔探针，其中在染色体中用苯基封端。 还提供了使用标签的方法。

    METHOD AND DEVICE FOR ANNIHILATION OF Staphylococcus aureus
    6.
    发明申请
    METHOD AND DEVICE FOR ANNIHILATION OF Staphylococcus aureus 审中-公开

    公开(公告)号：US20200306295A1

    公开(公告)日：2020-10-01

    申请号：US16580113

    申请日：2019-09-24

    Applicant: Purdue Research Foundation

    Inventor： Ji-xin Cheng ,  Mohamed Seleem ,  Pu-Ting Dong ,  Jie Hui

    IPC: A61K33/40 ,  A61L2/00 ,  A61L2/26 ,  A61P31/04 ,  A61K31/7028

    Abstract: Confronted with the rapid evolution and dissemination of antibiotic resistance, there is an urgent need to develop alternative treatment strategies for drug-resistant S. aureus, especially for methicillin-resistant S. aureus (MRSA). We report a photonic approach to eradicate MRSA through blue-light photolysis of staphyloxanthin (STX), an anti-oxidative carotenoid acting as the constituent lipid of the functional membrane microdomains of S. aureus. Our transient absorption imaging study and mass spectrometry unveil the photolysis process of STX. After effective STX photolysis by pulsed laser, cell membranes are found severely disorganized and malfunctioned to defense antibiotics, as unveiled by membrane permeabilization, membrane fluidification, and detachment of membrane protein, PBP2a. Consequently, our photolysis approach sensitizes MRSA to reactive oxygen species attack and increases susceptibility and inhibits development of resistance to a broad spectrum of antibiotics including penicillins, quinolones, tetracyclines, aminoglyco sides, lipopeptides, and oxazolidinones. The synergistic therapy, without phototoxicity to the host, is effective in combating MRSA both in vitro and in vivo in a mice skin infection model. Collectively, this staphyloxanthin-targeted phototherapy concept paves a novel platform to use conventional antibiotics as well as reactive oxygen species to combat multidrug-resistant S. aureus infections.

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