公开(公告)号：US20180313764A1

公开(公告)日：2018-11-01

申请号：US15770930

申请日：2016-09-27

Applicant: Purdue Research Foundation

Inventor： Garth Jason Simpson ,  Paul David Schmitt ,  Scott Robert Griffin ,  Casey Jake Smith

IPC: G01N21/70 ,  G01N21/01

CPC classification number: G01N21/70

Abstract: An impact-driven apparatus and method to achieve triboluminescence of homochiral API crystals as a measurement tool for rapidly assessing the presence of trace crystallinity within nominally amorphous pharmaceutical powders. The apparatus may include a kinetic energy director and two plates which hold a sample for testing. The triboluminescence may also be achieve by an acoustic transducer.

公开(公告)号：US10309902B2

公开(公告)日：2019-06-04

申请号：US15514893

申请日：2015-09-28

Applicant: Purdue Research Foundation

Inventor： Garth Jason Simpson ,  Paul David Schmitt

IPC: G01N21/00 ,  G01N21/65 ,  G01N23/207 ,  G01N21/63

Abstract: A method for quantifying crystallinity within a sample using second harmonic generation microscopy is described herein. In one aspect, a method for reducing the timeframe for accelerated stability testing of amorphous solid dispersions of active pharmaceutical ingredients though identifying regions of interest to quantify crystallinity and composition is presented herein.

公开(公告)号：US20170212053A1

公开(公告)日：2017-07-27

申请号：US15514893

申请日：2015-09-28

Applicant: Purdue Research Foundation

Inventor： Garth Jason Simpson ,  Paul David Schmitt

IPC: G01N21/65 ,  G01N23/207

CPC classification number: G01N21/65 ,  G01N21/636 ,  G01N23/207 ,  G01N2223/606 ,  G01N2223/612

Abstract: A method for quantifying crystallinity within a sample using second harmonic generation microscopy is described herein. In one aspect, a method for reducing the timeframe for accelerated stability testing of amorphous solid dispersions of active pharmaceutical ingredients though identifying regions of interest to quantify crystallinity and composition is presented herein.