公开(公告)号：EP0100463B1

公开(公告)日：1987-10-07

申请号：EP83106737.6

申请日：1983-07-08

Applicant: RADIOMETER A/S

Inventor： Pedersen, Knud Gronlund

IPC: G01N27/46 ,  G01N27/56 ,  A61B5/14

CPC classification number: A61B5/14542 ,  A61B5/1477 ,  G01N27/404

公开(公告)号：EP0127148B1

公开(公告)日：1993-04-14

申请号：EP84105955.3

申请日：1984-05-24

Applicant: RADIOMETER A/S

Inventor： Klitgaard, Peter Christian ,  Pedersen, Knud Gronlund

IPC: G01N27/416 ,  A61B5/00

CPC classification number: A61B5/1477 ,  A61B5/04004 ,  A61B5/0448 ,  A61B5/14542 ,  A61B5/4362 ,  A61B2562/0215 ,  A61B2562/0217

公开(公告)号：EP0127148A1

公开(公告)日：1984-12-05

申请号：EP84105955.3

申请日：1984-05-24

Applicant: RADIOMETER A/S

Inventor： Klitgaard, Peter Christian ,  Pedersen, Knud Gronlund

IPC: G01N27/416 ,  A61B5/00

CPC classification number: A61B5/1477 ,  A61B5/04004 ,  A61B5/0448 ,  A61B5/14542 ,  A61B5/4362 ,  A61B2562/0215 ,  A61B2562/0217

Abstract: An electrode assemblyfortranscutaneously measuring a blood gas parameter and for measuring a bioelectrical signal comprises two separate electrode devices (10, 40), one of which (10) further comprises an electrochemical measuring electrode system. The electrochemical measuring electrode system comprises a reference electrode of a potentiometric electrode system and an anode of a polarographic electrode system constituted by a single metallic body (13), a pH-electrode (31,32) of the potentiometric electrode system, and a noble metal cathode (33 34) of the polarographic electrode system. The biolectrical signal sensing electrode of the electrode device (10) is further constituted by the metallic body (13). A first part of the metallic body (13) is covered by an electrolyte solution (28) which communicates electrolytically therewith and further with the pH-glass electrode and the noble metal cathode, and a second part of which is not covered by the electrolyte solution but adapted to electrically conductively communicate with a skin surface part of a test person or a patient through an electrically conductive contact liquid (19). The membrane separates the first and the second part of the metallic body from one another. The second electrode (40) comprises a bioelectrical signal sensing electrode (41), which is adapted to electrically conductively communicate with a skin surface part of a test person or patient through an electrically conductive contact liquid (20). By means of the electrode assembly coincident measuring results of the blood gas partial pressures of oxygen and carbon dioxide and of a bioelectrical signal such as the ECG (Electrocardiography), the RR (Respiration rate) or the heart rate of the test person or patient is obtainable (Fig. 3).

Abstract translation: 单独的电极组件，用于经皮测量血液气体参数和用于测量生物电信号由两个电极装置（10，40），其中一个（10）电化学测量电极系统进一步包括。电化学测量电极系统包括一个参考电极 一个电位电极系统和由单个金属体（13），所述电位电极系统的pH电极（31，32），和极谱的贵金属阴极（33 34）构成的极谱电极系统的阳极 电极系统。该电极装置（10）的biolectrical信号感测电极是由另外的金属本体（13）构成。 金属体（13）的第一部分是通过在电解质溶液（28）有连通电解那里与并进一步用pH玻璃电极和贵金属阴极，并且其不包括在电解质溶液中的所有的第二部分覆盖 但angepasst到导电与测试人的皮肤表面部分或通过在导电接触液体（19）的患者进行通信。 膜分离第一和金属体的彼此的第二部分。 所述第二电极（40）包括一个生物电信号的感测电极（41），所有这些是angepasst到导电与测试人或患者的皮肤表面部分通过在导电的接触液体（20）进行通信。 ... 由电极组件重合测量氧气和二氧化碳的和生物电信号的血液气体分压的结果的方式：如ECG（心电图），则RR（呼吸率）或的的心脏速率 测试者或病人得到A.

公开(公告)号：EP0100463A1

公开(公告)日：1984-02-15

申请号：EP83106737.6

申请日：1983-07-08

Applicant: RADIOMETER A/S

Inventor： Pedersen, Knud Gronlund

IPC: G01N27/46 ,  G01N27/56 ,  A61B5/14

CPC classification number: A61B5/14542 ,  A61B5/1477 ,  G01N27/404

Abstract: An electrochemical electrode device for simultaneously measuring the partial pressures of two gases in a medium of limited gas availability one of which is measured potentiometrically and another one of which is measured polarographically comprises an electrode body (18) constituting a reference electrode relative. to a pH-electrode (19) of a potentiometric electrode system, and a anode relative to a cathode (20) of a polarographic electrode system. Furthermore, the electrode device comprises an electrolyte solution (28) enclosed between the electrode body (18) and a membrane (30). The membrane (30) comprises a basic membrane layer (31), preferably of polytetrafluoroethylene (PTFE) or fluorcethylenepropylene (FEP) of a thickness of about 12 µm, and a covering (32), preferably a polypropylene layer of a thickness of about 15 µm, which covers part of the basic membrane layer so that an uncovered area (34) is constituted in front of the pH-electrode (19). The uncovered area (34) constitutes a first membrane part showing high permeability to the first gas and constitutes together with the potentiometric electrode system and the electrolyte solution a first measuring system for measuring the partial pressure of the first gas. A covered area (32) of the basic membrane layer (30) constitutes together with its covering a second membrane part showing low permeability to the second gas and is arranged In front of the exposed measuring surface of the cathode (20) so as to restrict the diffusion of the second gas to the cathode (20) and together with the polarographic electrode system and the electrolyte solution to constitute a second measuring system for measuring the partial pressure of the second gas. In order to obtain highly accurate and highly responsive measurements of the partial pressures of the two gases in a medium of limited gas availability, the dimension of the exposed measuring surface of the cathode (20), which preferably is a micro-cathode constituted by a 25 µm platinum wire, (22) and the permeability of the second membrane part (32) are adapted to one another so that the response of the polarographic measuring system when measuring in a medium of limited gas availability is substantially identical to the response of the polarographic measuring system when measuring in a medium of unlimited gas availability, and the potentiometric and the polarographic measuring systems have response time characteristics of the same order of magnitude, such as response time constants of the order of 0.5 min.