公开(公告)号：EP0077073A2

公开(公告)日：1983-04-20

申请号：EP82109436.4

申请日：1982-10-12

Applicant: RADIOMETER A/S

Inventor： Baumbach, Per Lennart ,  Poulsen, Jorgen

IPC: A61B5/00

CPC classification number: G01K1/16 ,  A61B5/14542 ,  A61B5/1477 ,  A61B5/1491 ,  G01K1/165 ,  G01K1/20

Abstract: In accordance with the principles for transcutaneous measurement of a blood parameter, such as the partial pressure of a blood gas, an electrochemical measuring electrode device (1) is applied to the skin surface (2) of a person. The electrode device comprises a body (10), e.g. a thick film substrate, which is thermostated to a predetermined temperature and, furthermore, includes sensor means (11) together with a membrane (14) confining an electrolyte solution within an electrolyte reservoir (15). Furthermore, the electrode device includes a jacket comprising an annular metallic body (16), a metallic body (4) and a thick film substrate (8) which is thermostated to the same temperature as the body (10) of the electrode device. When the body is brought into contact with the skin surface, an annular surface part of the jacket is also brought into contact with the skin surface so that a virtual heating jacket is established in the skin beneath the annular surface part so as to substantially direct all heat flow from the body to tissue directly beneath the skin surface. By measuring the power supplied for thermostating the body to the predetermined temperature, the local capillary blood flow in the tissue (2) beneath the skin is measured, and the blood parameter in question is measured by means of the sensor means (11). In an alternative operational mode, the electrode device is adapted to measure deep body temperature by thermostating the jacket to a temperature so that the temperature registered by a temperature sensor of the body and the temperature registered by a temperature sensor of the jacket are identical to one another and, consequently, identical to the deep body temperature.

Abstract translation: 根据血液参数（例如血液分压）的经皮测定的原理，将电化学测量电极装置（1）施加到人的皮肤表面（2）。 电极装置包括主体（10） 厚膜基板，其被恒温至预定温度，此外，还包括传感器装置（11）以及将电解质溶液限制在电解质储存器（15）内的膜（14）。 此外，电极装置包括一个外壳，它包括环形金属体（16），金属体（4）和厚膜基片（8），它被恒温到与电极装置本体（10）相同的温度。 当身体与皮肤表面接触时，护套的环形表面部分也与皮肤表面接触，使得在环形表面部分下方的皮肤中建立虚拟加热护套，以便基本上引导所有 从身体到皮肤表面正下方的组织热流。 通过测量用于使身体恒温至预定温度的功率，测量皮肤下面的组织（2）中的局部毛细血管血流，并且通过传感器装置（11）测量所讨论的血液参数。 在替代操作模式中，电极装置适于通过将套管恒温到温度来测量体温，使得由身体的温度传感器记录的温度和由护套的温度传感器记录的温度与一个温度传感器相同 另一个，因此与深层体温相同。

公开(公告)号：EP0039136B1

公开(公告)日：1985-12-04

申请号：EP81301299.4

申请日：1981-03-26

Applicant: RADIOMETER A/S

Inventor： Poulsen, Jorgen

IPC: G01N27/28 ,  G01N27/46

CPC classification number: A61B5/14542 ,  A61B5/1477 ,  A61B5/1491 ,  G01N27/404 ,  G01N27/4162

公开(公告)号：EP0039136A3

公开(公告)日：1982-01-20

申请号：EP81301299

申请日：1981-03-26

Applicant: RADIOMETER A/S

Inventor： Poulsen, Jorgen

IPC: G01N27/28 ,  G01N27/46

CPC classification number: A61B5/14542 ,  A61B5/1477 ,  A61B5/1491 ,  G01N27/404 ,  G01N27/4162

Abstract: An electrode device for electrochemical measurement of the concentration of the partial pressure of a gas in a liquid or a gas mixture; comprises a measuring surface constituted by or comprising the sensitive part (4) of a measuring electrode and a membrane (6). placed in front of the measuring surface and delimiting a volume of electrolyte solution (5) which is in contact with the measuring electrode. The membrane is permeable to thegas to be determined, and a given distance is obtained and maintained between the measuring surface and the membrane by means of particles (7). When assembling the electrode device, a dispersion of the particles in the electrolyte to be incorporated in the electrode device is applied on the measuring surface and/or the membrane in excess, and the electrode device is assembled, whereby excess dispersion is pressed out. The dispersion of the particles in the electrolyte is gelled so that it is stable. By using particles for obtaining and maintaining the distance between the measuring surface and the membrane, it is possible to obtain very small distances between the measuring surface and the membrane, and the thickness of thin electrolyte layers is easy to control using particles, thus reducing the response time of the electrode. Furthermore, the thickness of the electrolyte layer is adjusted automatically when assembling the electrode device and the membrane between which a dispersion of particles is placed.

公开(公告)号：EP0077073A3

公开(公告)日：1985-10-23

申请号：EP82109436

申请日：1982-10-12

Applicant: RADIOMETER A/S

Inventor： Baumbach, Per Lennart ,  Poulsen, Jorgen

IPC: A61B05/00

CPC classification number: G01K1/16 ,  A61B5/14542 ,  A61B5/1477 ,  A61B5/1491 ,  G01K1/165 ,  G01K1/20

Abstract: In accordance with the principles for transcutaneous measurement of a blood parameter, such as the partial pressure of a blood gas, an electrochemical measuring electrode device (1) is applied to the skin surface (2) of a person. The electrode device comprises a body (10), e.g. a thick film substrate, which is thermostated to a predetermined temperature and, furthermore, includes sensor means (11) together with a membrane (14) confining an electrolyte solution within an electrolyte reservoir (15). Furthermore, the electrode device includes a jacket comprising an annular metallic body (16), a metallic body (4) and a thick film substrate (8) which is thermostated to the same temperature as the body (10) of the electrode device. When the body is brought into contact with the skin surface, an annular surface part of the jacket is also brought into contact with the skin surface so that a virtual heating jacket is established in the skin beneath the annular surface part so as to substantially direct all heat flow from the body to tissue directly beneath the skin surface. By measuring the power supplied for thermostating the body to the predetermined temperature, the local capillary blood flow in the tissue (2) beneath the skin is measured, and the blood parameter in question is measured by means of the sensor means (11). In an alternative operational mode, the electrode device is adapted to measure deep body temperature by thermostating the jacket to a temperature so that the temperature registered by a temperature sensor of the body and the temperature registered by a temperature sensor of the jacket are identical to one another and, consequently, identical to the deep body temperature.

公开(公告)号：EP0077073B1

公开(公告)日：1989-08-09

申请号：EP82109436.4

申请日：1982-10-12

Applicant: RADIOMETER A/S

Inventor： Baumbach, Per Lennart ,  Poulsen, Jorgen

IPC: A61B5/00

CPC classification number: G01K1/16 ,  A61B5/14542 ,  A61B5/1477 ,  A61B5/1491 ,  G01K1/165 ,  G01K1/20

公开(公告)号：EP0039136A2

公开(公告)日：1981-11-04

申请号：EP81301299.4

申请日：1981-03-26

Applicant: RADIOMETER A/S

Inventor： Poulsen, Jorgen

IPC: G01N27/28 ,  G01N27/46

CPC classification number: A61B5/14542 ,  A61B5/1477 ,  A61B5/1491 ,  G01N27/404 ,  G01N27/4162

Abstract: An electrode device for electrochemical measurement of the concentration of the partial pressure of a gas in a liquid or a gas mixture; comprises a measuring surface constituted by or comprising the sensitive part (4) of a measuring electrode and a membrane (6). placed in front of the measuring surface and delimiting a volume of electrolyte solution (5) which is in contact with the measuring electrode. The membrane is permeable to thegas to be determined, and a given distance is obtained and maintained between the measuring surface and the membrane by means of particles (7).
When assembling the electrode device, a dispersion of the particles in the electrolyte to be incorporated in the electrode device is applied on the measuring surface and/or the membrane in excess, and the electrode device is assembled, whereby excess dispersion is pressed out.
The dispersion of the particles in the electrolyte is gelled so that it is stable.
By using particles for obtaining and maintaining the distance between the measuring surface and the membrane, it is possible to obtain very small distances between the measuring surface and the membrane, and the thickness of thin electrolyte layers is easy to control using particles, thus reducing the response time of the electrode. Furthermore, the thickness of the electrolyte layer is adjusted automatically when assembling the electrode device and the membrane between which a dispersion of particles is placed.

Abstract translation: 用于电化学测量液体或气体混合物中气体分压浓度的电极装置包括由测量电极的敏感部分（4）构成或包括测量电极的测量表面，以及放置在测量电极 测量表面的前面并限定与测量电极接触的电解质溶液（5）的体积。 膜对待测定的气体是可渗透的，并且通过颗粒（7）获得并保持在测量表面和膜之间的给定距离。 当组装电极装置时，将要结合在电极装置中的电解质中的颗粒的分散体过量地施加在测量表面和/或膜上，并且组装电极装置，从而将多余的分散体压出。 颗粒在电解质中的分散体凝胶化，使其稳定。 通过使用用于获得和维持测量表面和膜之间的距离的颗粒，可以在测量表面和膜之间获得非常小的距离，并且薄的电解质层的厚度易于使用颗粒进行控制，从而减少 电极的响应时间。 此外，当组装电极装置和其上放置有颗粒分散体的膜时，自动调节电解质层的厚度。