公开(公告)号：AU635211B2

公开(公告)日：1993-03-18

申请号：AU3850689

申请日：1989-06-23

Applicant: RESEARCH TRIANGLE INSTITUTE

Inventor： C. EDGAR COOK ,  DOUGLAS RECTOR ,  JERRY R. REEL ,  YUE-WEI LEE ,  MANSUKH C. WANI

IPC: A61K31/57 ,  A61K31/00 ,  A61K31/58 ,  A61P3/08 ,  A61P5/00 ,  A61P5/24 ,  A61P13/02 ,  A61P15/00 ,  C07J5/00 ,  C07J7/00 ,  C07J13/00 ,  C07J41/00 ,  C07J43/00 ,  C07J53/00 ,  C07J71/00

Abstract: A 11 beta -aryl-19-norprogesterone steroid of the formula: wherein (i) R1 is H, C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, OH, OC(O)CH3, or OC(O)R5 , wherein R5 is C2-8 alkyl, C2-8 alkenyl, C2-8 alkynyl or aryl, R2 is H, R3 is H, C1-4 alkyl, C2-4 alkenyl or C2-4 alkynyl, R4 is H, CH3, F or Cl, R6 is H, (CH3)2N, CH3O, CH3CO, CH3S, CH3SO, CH3SO2, and X is O or NOCH3; or (ii) R1 and R2 taken together are a carbon-carbon bond and R3, R4, R6 and X are as defined above; or (iii) R1 and R3 taken together are -CH2- or -N=N-CH2-, R2 is H and R4, R6 and X are as defined above; or (iv) R2 and R3 taken together are =CH2 and R1 , R4, R6 and X are as defined above.