公开(公告)号：EP1087924A1

公开(公告)日：2001-04-04

申请号：EP99925110.1

申请日：1999-06-16

Applicant: RHODIA CHIMIE

Inventor： JOUVE, Isabelle ,  FOURNET, Frédéric ,  FRAGNON, Jean

IPC: C07C51/367 ,  C07C59/64 ,  C07C59/52 ,  C07C51/377 ,  C07C45/67

CPC classification number: C07C51/367 ,  C07C59/52 ,  C07C59/64

Abstract: The invention concerns a method for preparing p-hydroxymandelic compounds optionally substituted and their derivatives. More particularly, it concerns a method for preparing p-hydroxymandelic acid and methoxy-3 p-hydroxymandelic acid and their derivatives. The invention concerns a method for preparing p-hydroxymandelic compounds optionally substituted and their derivatives, which consists in condensing in water, in the presence of an alkaline agent, an aromatic compound bearing at least a hydroxyl group and whereof the position in para is free, with glyoxylic acid, said method being characterised in that the reaction is carried out in the presence of an efficient amount of a compound bearing at least two carboxylic functions.

公开(公告)号：EP1087924B1

公开(公告)日：2004-02-25

申请号：EP99925110.1

申请日：1999-06-16

Applicant: RHODIA CHIMIE

Inventor： JOUVE, Isabelle ,  FOURNET, Frédéric ,  FRAGNON, Jean

IPC: C07C51/367 ,  C07C59/64 ,  C07C59/52 ,  C07C51/377 ,  C07C45/67

CPC classification number: C07C51/367 ,  C07C59/52 ,  C07C59/64

公开(公告)号：EP0779883B1

公开(公告)日：2000-08-16

申请号：EP96904139.1

申请日：1996-02-14

Applicant: RHODIA CHIMIE

Inventor： METIVIER, Pascal ,  JOUVE, Isabelle ,  MALIVERNEY, Christian

IPC: C07C45/67 ,  C07C47/575 ,  C07C47/58 ,  C07C65/21 ,  C07C51/15 ,  C07C51/367 ,  C07C51/373

CPC classification number: C07C51/15 ,  C07C45/676 ,  C07C51/367 ,  C07C47/58 ,  C07C47/575 ,  C07C65/21

Abstract: A method for preparing a 4-hydroxybenzaldehyde having at least one substituent in the ortho position of the OH group, is disclosed. In particular, the preparation of 3-methoxy-4-hydroxybenzaldehyde and 3-ethoxy-4-hydroxybenzaldehyde is disclosed. The method for preparing a 4-hydroxybenzaldehyde which is at least 3-substituted by an alkoxy group comprises a step wherein a phenol compound which is at least 2-substituted by an alkoxy group and has positions 4 and 6 free is carboxylated in position 6 then hydroxymethylated in position 4, followed by a step of oxidising the hydroxymethyl group to a formyl group, and finally a decarboxylation step.