公开(公告)号：WO2005023731A3

公开(公告)日：2005-05-12

申请号：PCT/FR2004002021

申请日：2004-07-28

Applicant: RHODIA CHIMIE SA ,  SPINDLER JEAN-FRANCIS ,  TAILLEFER MARC ,  CRISTAU HENRI-JEAN ,  CELLIER PASCAL PHILIPPE ,  OUALI ARMELLE

Inventor： SPINDLER JEAN-FRANCIS ,  TAILLEFER MARC ,  CRISTAU HENRI-JEAN ,  CELLIER PASCAL PHILIPPE ,  OUALI ARMELLE

IPC: C07B37/04 ,  C07B41/04 ,  C07B41/08 ,  C07B41/12 ,  C07B43/06 ,  C07C41/16 ,  C07C67/04 ,  C07C67/343 ,  C07D231/12

CPC classification number: C07D231/12 ,  C07B37/04 ,  C07B41/04 ,  C07C41/16 ,  C07C67/343 ,  C07C69/612 ,  C07C43/275

Abstract: The invention relates to a method for forming a carbon-carbon or carbon-heteroatom bond by reacting an unsaturated compound carrying a leaving group and a nucleophilic compound, in the absence of a ligand. The aim of the invention is especially to form carbon-nitrogen bonds according to a method for the arylation of nitrogenated organic derivatives. According to the inventive method, a carbon-carbon or carbon-heteroatom bond is formed by reacting an unsaturated compound carrying a leaving group with a nucleophilic compound donating a carbon atom or a heteroatom (HE) that can substitute the leaving group, thus forming a C-C or C-HE bond, in the presence of a copper-based catalyst and a base. Said metal is characterised in that the reaction takes place in the absence of a ligand and in a nitrile-type solvent.

Abstract translation: 本发明涉及通过在不存在配体的情况下使带有离去基团的不饱和化合物与亲核化合物反应形成碳 - 碳或碳 - 杂原子键的方法。 本发明的目的尤其是根据氮化有机衍生物的芳基化方法形成碳 - 氮键。 根据本发明的方法，通过使带有离去基团的不饱和化合物与赋予碳原子的亲核化合物或可以代替离去基团的杂原子（HE）反应形成碳 - 碳或碳 - 杂原子键，从而形成 CC或C-HE键，在铜基催化剂和碱的存在下进行。 所述金属的特征在于反应在不存在配体的情况下和腈类溶剂中进行。

公开(公告)号：FR2859205A1

公开(公告)日：2005-03-04

申请号：FR0310253

申请日：2003-08-28

Applicant: RHODIA CHIMIE SA

Inventor： TAILLEFER MARC ,  CRISTAU HENRI JEAN ,  CELLIER PASCAL PHILIPPE ,  SPINDLER JEAN FRANCIS

IPC: C07B37/04 ,  C07B41/04 ,  C07B41/08 ,  C07B41/12 ,  C07B43/06 ,  C07C41/16 ,  C07C67/04 ,  C07C67/343 ,  C07D231/12 ,  C07C43/275 ,  C07C69/38

Abstract: The invention relates to a method for forming a carbon-carbon or carbon-heteroatom bond by reacting an unsaturated compound carrying a leaving group and a nucleophilic compound, in the absence of a ligand. The aim of the invention is especially to form carbon-nitrogen bonds according to a method for the arylation of nitrogenated organic derivatives. According to the inventive method, a carbon-carbon or carbon-heteroatom bond is formed by reacting an unsaturated compound carrying a leaving group with a nucleophilic compound donating a carbon atom or a heteroatom (HE) that can substitute the leaving group, thus forming a C-C or C-HE bond, in the presence of a copper-based catalyst and a base. Said metal is characterised in that the reaction takes place in the absence of a ligand and in a nitrile-type solvent.

公开(公告)号：FR2859205B1

公开(公告)日：2006-02-03

申请号：FR0310253

申请日：2003-08-28

Applicant: RHODIA CHIMIE SA

Inventor： TAILLEFER MARC ,  CRISTAU HENRI JEAN ,  CELLIER PASCAL PHILIPPE ,  SPINDLER JEAN FRANCIS

IPC: C07B37/04 ,  C07B41/04 ,  C07B41/08 ,  C07B41/12 ,  C07B43/06 ,  C07C41/16 ,  C07C43/275 ,  C07C67/04 ,  C07C67/343 ,  C07C69/38 ,  C07D231/12

Abstract: The invention relates to a method for forming a carbon-carbon or carbon-heteroatom bond by reacting an unsaturated compound carrying a leaving group and a nucleophilic compound, in the absence of a ligand. The aim of the invention is especially to form carbon-nitrogen bonds according to a method for the arylation of nitrogenated organic derivatives. According to the inventive method, a carbon-carbon or carbon-heteroatom bond is formed by reacting an unsaturated compound carrying a leaving group with a nucleophilic compound donating a carbon atom or a heteroatom (HE) that can substitute the leaving group, thus forming a C-C or C-HE bond, in the presence of a copper-based catalyst and a base. Said metal is characterised in that the reaction takes place in the absence of a ligand and in a nitrile-type solvent.