公开(公告)号：WO2006026602A3

公开(公告)日：2007-11-15

申请号：PCT/US2005030795

申请日：2005-08-30

Applicant: ROSALIND FRANKLIN UNIVERSITY O

Inventor： POTASHKIN JUDTH ANN

IPC: C12Q1/68 ,  C07H21/04 ,  C12P19/34

CPC classification number: C12Q1/6883 ,  C12Q2600/158

Abstract: The present invention provides a method of diagnosing a neurodegenerative disease in a mammalian subject, preferably a human subject. The method comprises obtaining RNA from the mammalian subject, and assaying the RNA for an increase in the amount of ?fosB mRNA or in ratio of the amount of ?FosB mRNA to the amount of FosB mRNA as compared to that of a control. An increase in the amount of ?FosB mRNA or the ratio of the amount of ?FosB mRNA to the amount of FosB mRNA as compared to that of the control is indicative of the presence of the neurodegenerative disease.

Abstract translation: 本发明提供了诊断哺乳动物受试者，优选人受试者的神经变性疾病的方法。 该方法包括从哺乳动物受试者获得RNA，并且与对照相比，测定RNA以增加αfosBmRNA的量，或以FosB mRNA的量与FosB mRNA的量的比例。 FosB mRNA的量的增加或与对照组相比，FosB mRNA与FosB mRNA的量的比例的增加表明存在神经变性疾病。