公开(公告)号：WO2006105044A1

公开(公告)日：2006-10-05

申请号：PCT/US2006/011166

申请日：2006-03-27

Applicant: ROSALIND FRANKLIN UNIVERSITY OF MEDICINE AND SCIENCE

Inventor： CHANG, Kwang-poo ,  KOLLI, Bala, Krishna ,  SASSA, Shigeru

IPC: A61K39/008 ,  C12N1/11

CPC classification number: A61K39/008 ,  A61K47/60 ,  A61K2039/522 ,  A61K2039/523 ,  C12N15/87 ,  Y02A50/41

Abstract: The present invention discloses the use of a mutant Leishmania as a suicidal vaccine wherein the mutant Leishmania is responsive to external signals to become porphyric and commit suicidal cytolysis. The mutant can be selected from natural Leishmania species or constructed by genetic engineering.

Abstract translation: 本发明公开了一种突变利什曼原虫作为自杀疫苗的应用，其中突变体利什曼原虫对外部信号响应变得卟啉并进行自杀性细胞溶解。 该突变体可以选自天然利什曼原虫，也可以通过遗传工程构建。