公开(公告)号：US20030170728A1

公开(公告)日：2003-09-11

申请号：US10295700

申请日：2002-11-15

Applicant: Randox Laboratories Limited

Inventor： Robert Ivan McConnell ,  Elouard Benchikh ,  Stephen Peter Fitzgerald ,  John Victor Lamont

IPC: G01N033/53 ,  C07D211/56 ,  C07K016/00 ,  C07K014/47

CPC classification number: G01N33/9486 ,  C07D211/58 ,  G01N33/531 ,  G01N2430/00

Abstract: The invention provides an immunogen comprising a hapten coupled to an antigenicity-conferring carrier material, a conjugate comprising the aforementioned hapten coupled to a labelling agent, as well as, antibodies raised against the aforementioned immunogen and capable of binding with at least one structural epitope of metabolites of fentanyl and of metabolites of fentanyl analogs.

Abstract translation: 本发明提供了一种免疫原，其包含与抗原性赋予载体材料偶联的半抗原，包含与标记试剂偶联的上述半抗原的缀合物，以及针对上述免疫原产生并能够与至少一种结构表位结合的抗体 芬太尼代谢物和芬太尼类似物的代谢产物。

公开(公告)号：US20030224447A1

公开(公告)日：2003-12-04

申请号：US10355348

申请日：2003-01-31

Applicant: Randox Laboratories Limited

Inventor： Robert Ivan McConnell ,  Elouard Benchikh ,  Stephen Peter Fitzgerald ,  John Victor Lamont

IPC: G01N033/53 ,  C07K014/00

CPC classification number: C07K16/44 ,  A61K47/64 ,  A61K47/646 ,  G01N33/94 ,  Y10S436/815 ,  Y10S436/823 ,  Y10S530/807 ,  Y10T436/13 ,  Y10T436/17

Abstract: The invention provides haptens, immunogens comprising such haptens coupled to an antigenicity-conferring carrier material, conjugates comprising such haptens bonded to a labelling agent as well as, antibodies raised against such immunogens and capable of binding with ketamine and its primary metabolite, norketamine.

Abstract translation: 本发明提供了半抗原，包含与赋予抗原性的载体材料偶联的这种半抗原的免疫原，包含与标记试剂结合的这种半抗原的缀合物，以及针对这种免疫原而产生并能够与氯胺酮及其主要代谢物诺替胺结合的抗体。