公开(公告)号：US09739704B2

公开(公告)日：2017-08-22

申请号：US13990692

申请日：2011-11-23

Applicant: Thomas Voit ,  Michael Geissler ,  Harald Quintel ,  Roman Gruler

Inventor： Thomas Voit ,  Michael Geissler ,  Harald Quintel ,  Roman Gruler

IPC: G01N21/03 ,  B01L3/00 ,  G01N21/64

CPC classification number: G01N21/03 ,  B01L3/50825 ,  B01L2300/043 ,  B01L2300/047 ,  B01L2300/0654 ,  G01N21/0303 ,  G01N2021/0378 ,  G01N2021/6482 ,  G01N2201/066

Abstract: Fluid processing tube for use in optical analysis comprising at least one first portion being made from a first material suitable for optical analysis and being configured to include two optical paths of different lengths, and at least one second portion connected to said first portion and being made from a second material different from said first material.

公开(公告)号：US20100110439A1

公开(公告)日：2010-05-06

申请号：US12449649

申请日：2008-02-25

Applicant: Roman Gruler ,  Konrad Faulstich

Inventor： Roman Gruler ,  Konrad Faulstich

IPC: G01N21/01 ,  G01N1/10 ,  G01N21/55 ,  G01T1/10

CPC classification number: G01N21/645 ,  G01N21/255 ,  G01N21/8483 ,  G01N2201/0228 ,  G01N2201/024

Abstract: The invention provides for an optical measuring instrument and measuring device. The optical measuring instrument for investigating a specimen contained in a sample comprises at least one source for providing at least one electromagnetic beam intended to irradiate the sample and to interact with the specimen within the sample, at least one sensor for detecting an output of the interaction between the specimen and the electromagnetic beam, an integrally formed mechanical bench for the optical and electronic components, a sample holder for holding the sample, wherein the at least one source, the at least one sensor, and the mechanical bench are integrated in one monolithic optoelectronic module and the sample holder can be connected to this module.

Abstract translation: 本发明提供一种光学测量仪器和测量装置。 用于调查包含在样品中的样本的光学测量仪器包括至少一个源，用于提供用于照射样品的至少一个电磁束并与样品内的样品相互作用，用于检测相互作用的输出的至少一个传感器 在样品和电磁束之间，用于光学和电子部件的整体形成的机械台，用于保持样品的样品保持器，其中所述至少一个源，所述至少一个传感器和所述机械台被集成在一个单片 光电模块和样品架可以连接到该模块。

公开(公告)号：US20080144028A1

公开(公告)日：2008-06-19

申请号：US11885068

申请日：2006-03-03

Applicant: Roman Gruler

Inventor： Roman Gruler

IPC: G01J3/30

CPC classification number: G01N21/6486 ,  B33Y80/00 ,  G01N21/645 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2201/024

Abstract: Disclosed is a fluorescence meter for analyzing a sample, comprising a main beam path and at least one optical module. The fluorescence meter is embodied so as to provide at least one electromagnetic beam for exciting the sample and receive at least one electromagnetic beam emitted by the sample, at least some sections of at least two of the electromagnetic beams being located on one plane while extending along the main beam path.

Abstract translation: 公开了一种用于分析样品的荧光计，包括主光束路径和至少一个光学模块。 荧光计的实施是为了提供至少一个电磁波束，用于激发样品并接收由样品发射的至少一个电磁波束，至少两个电磁波束的至少一些部分位于一个平面上，同时沿着 主梁路径。

公开(公告)号：US20130314697A1

公开(公告)日：2013-11-28

申请号：US13990692

申请日：2011-11-23

Applicant: Thomas Voit ,  Michael Geissler ,  Harald Quintel ,  Roman Gruler

Inventor： Thomas Voit ,  Michael Geissler ,  Harald Quintel ,  Roman Gruler

IPC: G01N21/03

CPC classification number: G01N21/03 ,  B01L3/50825 ,  B01L2300/043 ,  B01L2300/047 ,  B01L2300/0654 ,  G01N21/0303 ,  G01N2021/0378 ,  G01N2021/6482 ,  G01N2201/066

Abstract: Fluid processing tube for use in optical analysis comprising at least one first portion being made from a first material suitable for optical analysis and being configured to include two optical paths of different lengths, and at least one second portion connected to said first portion and being made from a second material different from said first material.

Abstract translation: 用于光学分析的流体处理管，包括至少一个由适于光学分析的第一材料制成的第一部分，并且被配置为包括两个不同长度的光路，以及至少一个连接到所述第一部分的第二部分，并被制成 从不同于所述第一材料的第二材料。

公开(公告)号：US08057041B2

公开(公告)日：2011-11-15

申请号：US12374772

申请日：2007-07-23

Applicant: Achim Müller ,  Peter Herbrechtsmeier ,  Klaus Haberstroh ,  Roman Gruler

Inventor： Achim Müller ,  Peter Herbrechtsmeier ,  Klaus Haberstroh ,  Roman Gruler

IPC: A61B3/00 ,  A61B3/10

CPC classification number: A61B5/1455 ,  A61B5/14532 ,  A61B2560/0223

Abstract: The invention proposes a manual measuring appliance (112) and an analytical measuring system (110) which can be used to measure at least one analyte in an eye fluid of an eye (114). The handheld measuring appliance (112) comprises a measuring system (120) and a positioning system (122). The measuring system (120) can measure at least one property of the at least one analyte and/or at least one analyte-dependent change of property of at least one ocular sensor (116) in the eye fluid, and this can be used to infer a concentration of the analyte in the eye fluid. The positioning system (122) is set up to measure a spatial positioning, wherein the spatial positioning comprises a distance between at least one measurement location in the eye (114) and the handheld measuring appliance (112) and also furthermore at least one further positioning co-ordinate. The positioning system (122) comprises at least one of the following systems: a camera system, particularly a monocular or binocular camera system, having at least one camera (410; 910); an image recognition system; a triangulation system; a propagation time measuring system, particularly for 1-, 2- or 3-dimensional propagation time measurement, particularly using at least one laser and/or at least one phase mix detector (PMD); a 1-, 2- or 3-dimensional intensity measuring system for at least one signal; a 2- or 3-dimensional magnetoresistive measuring system.

Abstract translation: 本发明提出了一种手动测量仪器（112）和分析测量系统（110），其可用于测量眼睛（114）的眼睛液体中的至少一种分析物。 手持式测量仪器（112）包括测量系统（120）和定位系统（122）。 测量系统（120）可以测量眼液中至少一种分析物的至少一种性质和/或至少一种分析物依赖的至少一种眼睛传感器（116）的性质变化，并且这可以用于 推测眼液中分析物的浓度。 定位系统（122）被设置为测量空间定位，其中空间定位包括眼睛（114）中的至少一个测量位置与手持式测量仪器（112）之间的距离，此外还包括至少一个另外的定位 坐标。 定位系统（122）包括以下系统中的至少一个：具有至少一个照相机（410; 910）的相机系统，特别是单目或双目相机系统。 图像识别系统; 三角测量系统; 传播时间测量系统，特别是对于1或2维或3维传播时间测量，特别是使用至少一个激光和/或至少一个相位混合检测器（PMD）; 用于至少一个信号的1，2或3维强度测量系统; 2或3维磁阻测量系统。

公开(公告)号：US20130320223A1

公开(公告)日：2013-12-05

申请号：US13990711

申请日：2011-11-23

Applicant: Harald Quintel ,  Elmar Christian Feuerbacher ,  Roman Gruler ,  Stuart Ronald Huckins ,  Dominik Zahr ,  Markus Rebholz ,  Robert Schild

Inventor： Harald Quintel ,  Elmar Christian Feuerbacher ,  Roman Gruler ,  Stuart Ronald Huckins ,  Dominik Zahr ,  Markus Rebholz ,  Robert Schild

IPC: G01J3/42

CPC classification number: G01J3/42 ,  G01J3/10 ,  G01J3/36 ,  G01J3/427 ,  G01N21/33

Abstract: A photometric device (18) for quantifying a nucleic acid in a sample (518) in a tube (58), comprises a light emission unit (28), a sample obtaining unit (38) for holding the tube (58) with the nucleic acid sample (518) and a detection unit (48) wherein the sample obtaining unit (38) is arranged in between the light emission unit (28) and the detection unit (48) in particular, the light emission unit (28) and the detection unit (48) are arranged to provide light through the sample obtaining unit (38) such that light of a first wavelength of about 230 nanometers and light of a second wavelength of about 260 nanometers are simultaneously detectable within the detection unit (48). The photometric device (18) allows for efficiently analysing the nucleic acid sample by only considering invisible light. In particular, content of nucleic acid such as particularly a RNA or a DNA and a nucleic acid/salt ratio can simultaneously be determined such that efficiency of quantification of the nucleic acid sample (518) can be increased. Furthermore, since in addition thereto the sample obtaining unit (38) is arranged to hold the tube (58) or cuvette and the light directly passes the sample (518) being arranged in the tube (58) or cuvette, loss of sample, contamination of sample, need of additional sample treatment equipment such as pipettes or additional tubes as well as frequent cleaning of optics of the photometric device can be printed or reduced.

Abstract translation: 用于量化管（58）中的样品（518）中的核酸的光度测量装置（18）包括发光单元（28），用于将核（58）保持在核上的样品获得单元（38） 酸样品（518）和检测单元（48），其中样品获得单元（38）特别地布置在发光单元（28）和检测单元（48）之间，发光单元（28）和 检测单元（48）被布置成通过样品获得单元（38）提供光，使得在检测单元（48）内同时可检测到约230纳米的第一波长的光和约260纳米的第二波长的光。 光度测量装置（18）允许通过仅考虑不可见光来有效地分析核酸样品。 特别地，可以同时确定诸如特别是RNA或DNA的核酸的含量和核酸/盐比，从而可以提高核酸样品（518）的定量效率。 此外，由于样品获取单元（38）除此之外还被配置成保持管（58）或试管，并且光直接通过布置在管（58）或试管中的样品（518），样品损失，污染 的样品，可以印刷或减少需要另外的样品处理设备，例如移液管或附加管，以及经常清洁光度测量装置的光学元件。

公开(公告)号：US08452363B2

公开(公告)日：2013-05-28

申请号：US12374866

申请日：2007-07-23

Applicant: Achim Müller ,  Peter Herbrechtsmeier ,  Klaus Haberstroh ,  Roman Gruler

Inventor： Achim Müller ,  Peter Herbrechtsmeier ,  Klaus Haberstroh ,  Roman Gruler

IPC: A61B5/00 ,  A61B3/00 ,  A61B3/10

CPC classification number: A61B5/1455 ,  A61B5/14532 ,  A61B2560/0223

Abstract: The invention proposes a manual measuring appliance (112) and an analytical measuring system (110) which can be used to measure at least one analyte in an eye fluid of an eye (114). The handheld measuring appliance (112) comprises a measuring system (120) and a positioning system (122). The measuring system (120) can measure at least one property of the at least one analyte and/or at least one analyte-dependent change of property of at least one ocular sensor (116) in the eye fluid, and this can be used to infer a concentration of the analyte in the eye fluid. The positioning system (122) is set up to measure a spatial positioning, wherein the spatial positioning comprises a distance between at least one measurement location in the eye (114) and the handheld measuring appliance (112) and also furthermore at least one further positioning co-ordinate. Furthermore, the handheld measuring appliance comprises a calibration system (128), wherein the calibration system (128) is set up to perform a comparison measurement of at least one analyte concentration in a body fluid and/or to adopt measurement data from a comparison measurement performed using a separate measuring appliance and to take them into account when determining the concentration of the at least one analyte.

Abstract translation: 本发明提出了一种手动测量仪器（112）和分析测量系统（110），其可用于测量眼睛（114）的眼睛液体中的至少一种分析物。 手持式测量仪器（112）包括测量系统（120）和定位系统（122）。 测量系统（120）可以测量眼液中至少一种分析物的至少一种性质和/或至少一种分析物依赖的至少一种眼睛传感器（116）的性质变化，并且这可以用于 推断眼液中分析物的浓度。 定位系统（122）被设置为测量空间定位，其中空间定位包括眼睛（114）中的至少一个测量位置与手持式测量仪器（112）之间的距离，此外还包括至少一个另外的定位 坐标。 此外，手持式测量仪器包括校准系统（128），其中设置校准系统（128）以对体液中的至少一种分析物浓度进行比较测量和/或采用来自比较测量的测量数据 使用单独的测量仪器执行，并在确定至少一种分析物的浓度时考虑它们。

公开(公告)号：US08269966B2

公开(公告)日：2012-09-18

申请号：US11885068

申请日：2006-03-03

Applicant: Roman Gruler

Inventor： Roman Gruler

IPC: G01J3/30

CPC classification number: G01N21/6486 ,  B33Y80/00 ,  G01N21/645 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2201/024

Abstract: Disclosed is a fluorescence meter for analyzing a sample, comprising a main beam path and at least one optical module. The fluorescence meter is embodied so as to provide at least one electromagnetic beam for exciting the sample and receive at least one electromagnetic beam emitted by the sample, at least some sections of at least two of the electromagnetic beams being located on one plane while extending along the main beam path.

Abstract translation: 公开了一种用于分析样品的荧光计，包括主光束路径和至少一个光学模块。 荧光计的实施是为了提供至少一个电磁波束，用于激发样品并接收由样品发射的至少一个电磁波束，至少两个电磁波束的至少一些部分位于一个平面上，同时沿着 主梁路径。

公开(公告)号：US20100053556A1

公开(公告)日：2010-03-04

申请号：US12374772

申请日：2007-07-23

Applicant: Achim Müller ,  Peter Herbbrechtsmeier ,  Klaus Haberstroh ,  Roman Gruler

Inventor： Achim Müller ,  Peter Herbbrechtsmeier ,  Klaus Haberstroh ,  Roman Gruler

IPC: A61B3/10 ,  G01C3/02

CPC classification number: A61B5/1455 ,  A61B5/14532 ,  A61B2560/0223

Abstract: The invention proposes a manual measuring appliance (112) and an analytical measuring system (110) which can be used to measure at least one analyte in an eye fluid of an eye (114). The handheld measuring appliance (112) comprises a measuring system (120) and a positioning system (122). The measuring system (120) can measure at least one property of the at least one analyte and/or at least one analyte-dependent change of property of at least one ocular sensor (116) in the eye fluid, and this can be used to infer a concentration of the analyte in the eye fluid. The positioning system (122) is set up to measure a spatial positioning, wherein the spatial positioning comprises a distance between at least one measurement location in the eye (114) and the handheld measuring appliance (112) and also furthermore at least one further positioning co-ordinate. The positioning system (122) comprises at least one of the following systems: a camera system, particularly a monocular or binocular camera system, having at least one camera (410; 910); an image recognition system; a triangulation system; a propagation time measuring system, particularly for 1-, 2- or 3-dimensional propagation time measurement, particularly using at least one laser and/or at least one phase mix detector (PMD); a 1-, 2- or 3-dimensional intensity measuring system for at least one signal; a 2- or 3-dimensional magnetoresistive measuring system.

Abstract translation: 本发明提出了一种手动测量仪器（112）和分析测量系统（110），其可用于测量眼睛（114）的眼睛液体中的至少一种分析物。 手持式测量仪器（112）包括测量系统（120）和定位系统（122）。 测量系统（120）可以测量眼液中至少一种分析物的至少一种性质和/或至少一种分析物依赖的至少一种眼睛传感器（116）的性质变化，并且这可以用于 推测眼液中分析物的浓度。 定位系统（122）被设置为测量空间定位，其中空间定位包括眼睛（114）中的至少一个测量位置与手持式测量仪器（112）之间的距离，此外还包括至少一个另外的定位 坐标。 定位系统（122）包括以下系统中的至少一个：具有至少一个照相机（410; 910）的相机系统，特别是单目或双目相机系统。 图像识别系统; 三角测量系统; 传播时间测量系统，特别是对于1或2维或3维传播时间测量，特别是使用至少一个激光和/或至少一个相位混合检测器（PMD）; 用于至少一个信号的1，2或3维强度测量系统; 2或3维磁阻测量系统。

公开(公告)号：US20060104062A1

公开(公告)日：2006-05-18

申请号：US11258988

申请日：2005-10-26

Applicant: Axel Heinrich ,  Bernhard Seiferling ,  Roman Gruler

Inventor： Axel Heinrich ,  Bernhard Seiferling ,  Roman Gruler

IPC: F21S6/00

CPC classification number: B29C35/0805 ,  B29C2035/0827 ,  B29L2011/0041 ,  G02B6/0006 ,  G02B6/10 ,  G02B6/42 ,  G02B6/4206 ,  G02B6/4298

Abstract: In an apparatus for the transport of the light emitted by a short-arc lamp (1) through its light outlet hole (13) to a desired location a number of light guides (5) are provided the light entry surfaces (50) of which are arranged at a predetermined location. In addition, a coupling element (3) is provided, which is arranged at a distance from the light outlet hole (13) of the short-arc lamp (1) and between the light outlet hole (13) and the light entry surfaces (50) of the light guides (5). The coupling element (3) is designed such that it collects the emitted light and couples it into the light guides (5) through the light entry surfaces (50) of the light guides (5).

Abstract translation: 在用于将由短弧灯（1）发射的光通过其出射孔（13）传输到所需位置的设备中，设有多个光导（5），其中光进入表面（50） 布置在预定位置。 另外，设置有与短弧灯（1）的出光孔（13）一定距离并且在出光孔（13）和光入射面（ 50）。 耦合元件（3）被设计成使得它收集发射的光并通过光导（5）的光入射表面（50）将其耦合到光导（5）中。