公开(公告)号：JPH08245524A

公开(公告)日：1996-09-24

申请号：JP5127295

申请日：1995-03-10

Applicant: SAGAMI CHEM RES

Inventor： FUCHIGAMI TAKAMASA ,  HIROZAWA TOMOTARI ,  WAKASA NORIKO

IPC: C07D295/02 ,  B01J23/652 ,  B01J23/656 ,  B01J23/85 ,  B01J23/889 ,  B01J23/89 ,  B01J31/02 ,  B01J31/20 ,  C07B43/04 ,  C07B61/00 ,  C07C209/50 ,  C07C211/08 ,  C07C211/35

Abstract: PURPOSE: To efficiently obtain amines useful as a raw material, etc., for medicines in high selectivity and yield under mild conditions by carrying out hydrogenation reduction of amides in the presence of a catalyst comprising an element, etc., of a group VIII of the periodic table. CONSTITUTION: Amides (e.g. N-acetylpiperidine) such as an aliphatic amide, an aromatic amide or a lactam is subjected to hydrogenation reduction in the presence of a catalyst comprising one or more kinds of elements such as rhodium, ruthenium and palladium selected from elements of group VIII of the periodic table and one or more kinds of elements such as molybdenum and tungsten selected from elements of group VIb of the periodic table to provide the objective amines.

公开(公告)号：JPH11130784A

公开(公告)日：1999-05-18

申请号：JP29436797

申请日：1997-10-27

Applicant: SAGAMI CHEM RES

Inventor： FUCHIGAMI TAKAMASA ,  SAITO YASUKO ,  HIROZAWA TOMOTARI

IPC: B01J27/12 ,  B01J31/02 ,  C07B61/00 ,  C07C315/04 ,  C07C317/18 ,  C07F7/18

Abstract: PROBLEM TO BE SOLVED: To provide a simple process for the production of a β-hydroxysulfoxide useful as a synthetic intermediate for pharmaceuticals and amino acids. SOLUTION: The objective β-hydroxysulfoxide derivative expressed by the general formula R (S=O)CH2 -CH(OSiR R R )-R (R , R , R and R are each independently an alkyl or an aromatic group; R is a (substituted)aromatic group or vinyl group) and/or β-hydroxysulfoxide expressed by the general formula R (S=O)CH2 -CH(OH)-R can be produced by reacting an aldehyde expressed by the general formula RHC=O with a sulfinylmethylsilane expressed by the general formula R (S=O)CH2 -SiR R R in the presence of fluorine ion.

公开(公告)号：JPH09241222A

公开(公告)日：1997-09-16

申请号：JP5135296

申请日：1996-03-08

Applicant: SAGAMI CHEM RES

Inventor： FUCHIGAMI TAKAMASA ,  HIROZAWA TOMOTARI ,  WAKASA NORIKO

IPC: B01J23/652 ,  B01J23/656 ,  C07B61/00 ,  C07C209/50 ,  C07C211/17

Abstract: PROBLEM TO BE SOLVED: To obtain an amine widely usable as e.g. a raw material for medicines, solvent, catalyst, ligand, under mild conditions in high yield and selectivity, by hydrogenating reduction of an amide in a hydrocarbon solvent in the presence of a specific catalyst. SOLUTION: This amine is obtained by hydrogenating reduction of an amide in the presence of a catalyst composed of at least one element selected from among group VIII elements (pref. rhodium, ruthenium, palladium) and at least one element selected from among group VIb elements (pref. molybdenum, tungsten) or group VIIb elements (pref. rhenium) [pref. Ru/Al2 O3 -Mo(CO)6 , Rh/Al2 O3 - Re2 (CO)10 ]. Using the above reaction, for example, (S)-N-(1-phenylethyl)acetamide is converted into (S)-N-(1-cyclohexylethyl)ethylamine.

公开(公告)号：JPH09241192A

公开(公告)日：1997-09-16

申请号：JP5135196

申请日：1996-03-08

Applicant: SAGAMI CHEM RES

Inventor： FUCHIGAMI TAKAMASA ,  HIROZAWA TOMOTARI ,  WAKASA NORIKO

IPC: C07C29/149 ,  C07B61/00 ,  C07C31/02

Abstract: PROBLEM TO BE SOLVED: To obtain an alcohol useful as a raw material for medicines, a perfume, etc., under mild conditions in high yield and in high selectivity by a catalytic hydrogenation reduction of a carboxylic acid. SOLUTION: (B) A carboxylic acid is hydrogenated and reduced in a hydrocarbon-based solvent in the presence of (A) a catalyst comprising at least one of elements of the group VIII (preferably rhodium, ruthenium or palladium) of the periodic table and at least one of elements of the group VIb (preferably molybdenum or tungsten) or an element of the group VII (preferably rhenium). The catalyst of the component A may be supported on a carrier. The amount of the catalyst used is preferably 0.01-10mol% based on the component B.