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    PROCESS FOR PRODUCING A PEPTIDE
    3.
    发明专利
    PROCESS FOR PRODUCING A PEPTIDE 未知

    公开(公告)号：CA1059938A

    公开(公告)日：1979-08-07

    申请号：CA263981

    申请日：1976-10-22

    Applicant: SAGAMI CHEM RES

    Inventor： ISOWA YOSHIKAZU ,  OHMORI MUNEKI ,  KURITA HIDEAKI ,  ICHIKAWA TETSUYA ,  SATO MASANARI ,  MORI KAORU

    IPC: C07K1/02 ,  C07K5/072 ,  C07K5/093 ,  C12P21/02 ,  C12D13/06

    Abstract: A peptide having the formula X-A-B-Y wherein A and B are the same or different and each represents an amino acid residue or a peptide residue, X represents an amino protective group, Y represents a carboxyl protective group selected from the group consisting of tertiary alkoxy, and benzyloxy, benzylamino and benzhydrylamino which can be substituted with an inert substituent is prepared by a process which comprises reacting an amino acid or peptide having an N-terminal protective group, or a salt thereof of the formula: X-A-OH with an an amino acid or peptide having a C-terminal protective group or a salt thereof of the formula: H-B-Y in the presence of thiol proteinase or serine proteinase enzyme in an aqueous solution having a pH sufficient to maintain the enzyme activity of said thiol proteinase or serine proteinase.

    10.
    发明专利
    未知

    公开(公告)号：DD136737A5

    公开(公告)日：1979-07-25

    申请号：DD20341978

    申请日：1978-01-25

    Applicant: TOYO SODA MFG CO LTD ,  SAGAMI CHEM RES

    Inventor： ISOWA YOSHIKAZU ,  OHMORI MUNEKI ,  MORI KAORU ,  ICHIKAWA TETSUYA ,  NONAKA YUJI ,  KIHARA KEIICHI ,  OYAMA KIYOTAKA ,  SATOH HEIJIRO ,  NISHIMURA SHIGEAKI

    IPC: C07K5/072 ,  C07K5/075 ,  C07C103/52

    Abstract: Addition compounds have the formula (I) wherein R1 represents an aliphatic oxycarbonyl group, benzyloxycarbonyl group which can have nuclear substituents or benzoyl, aromatic sulfonyl or aromatic sulfinyl group; R2 represents methyl, isopropyl, isobutyl, isoamyl or benzyl group; R3 represents a lower alkoxyl, benzyloxy or benzhydryloxy group and n represents 1 or 2. The addition compounds are produced by reacting an N-substituted monoaminodicarboxylic acid having the formula (IV) with an amino carboxlic acid ester having the formula (V) in an aqueous medium in the presence of a protease and reacting the resulting dipeptide ester with the amino carboxylic acid ester and separating the addition compound. The addition compounds can be decomposed into the constituent dipeptide esters and amino acid esters by the action of an acid.

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