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    SUBSTANCE HAVING ANTITUMOR ACTIVITY
    3.
    发明专利
    SUBSTANCE HAVING ANTITUMOR ACTIVITY 失效

    公开(公告)号：JPH01191694A

    公开(公告)日：1989-08-01

    申请号：JP1575488

    申请日：1988-01-28

    Applicant: SAGAMI CHEM RES

    Inventor： SAKAI KUNIKAZU ,  YAMADA KAORU ,  ISHII YOSHIMITSU ,  YAZAWA KAZUYOSHI ,  ARAKI KEIKO ,  KONDO SEI

    IPC: C12N1/20 ,  A61K35/74 ,  A61K38/00 ,  A61P35/00 ,  C07K14/00 ,  C07K14/005 ,  C07K14/195 ,  C07K14/41 ,  C12P21/00 ,  C12R1/01

    Abstract: NEW MATERIAL:A substance SATS 2542 having an antitumor activity and the following physicochemical properties and produced by an microorganism belonging to the genus Alteromonas. Decomposition point: decomposes at 213-245 deg.C into a brown color; specific rotation: [alpha] D=+25 deg.(c=0.02, water); an aqueous solution of 1.0mg/ml is weekly acidic - neutral: solubility:soluble in water and slightly soluble or insoluble in organic solvents such as alcohols. acetone, ethyl ether, hexane, chloroform and ethyl acetate, mol. wt.:>=100,000 (gel filtration method); coloring reaction: positive to biuret reaction. Folin's reaction, anthrone sulfuric acid reaction and cysteine sulfuric acid reaction and negative to ninhydrin reaction, etc. USE:An antitumor agent. PREPARATION:Alteromonas sp.SCRC-2542 (FERM P-9819) is cultured.

    PRODUCTION OF FLUORINE-CONTAINING CARBOXYLIC ACID ESTER
    6.
    发明专利
    PRODUCTION OF FLUORINE-CONTAINING CARBOXYLIC ACID ESTER 失效

    公开(公告)号：JPS63152342A

    公开(公告)日：1988-06-24

    申请号：JP30133286

    申请日：1986-12-19

    Applicant: SAGAMI CHEM RES

    Inventor： FUCHIGAMI TAKAMASA ,  URATA HISAO ,  ISHII YOSHIMITSU ,  OBATA YOSHIKO

    IPC: C07C67/36 ,  B01J31/16 ,  C07B61/00 ,  C07C69/62 ,  C07C69/63

    Abstract: PURPOSE:To obtain the titled compound useful as synthetic intermediate for various valuable compounds, safely at a low cost, by reacting a fluorine- containing alkyl halide with carbon monoxide and an alcohol in the presence of a specific catalyst and a base. CONSTITUTION:The objective compound of formula III can be produced by reacting a compound of formula I (R is F or polyfluorocarbon residue; R and R are H, F, alkyl, etc.; R and R H, alkyl, etc.; R and R , R and R , R and R or R and R may together form a ring; X is I, Cl or Br) with an alcohol of formula II (R and R are H, alkyl, etc.; R and R may together form a ring) and carbon monoxide in the presence of a group VIII transition metal catalyst and a base such as an alkali metal, aromatic amine, etc., preferably at 40-120 deg.C. The amount of the catalyst is preferably 1/500-1/5 of the compound of formula I.

    PRODUCTION OF FLUORINE-CONTAINING CARBOXYLIC ACIDS
    9.
    发明专利
    PRODUCTION OF FLUORINE-CONTAINING CARBOXYLIC ACIDS 失效

    公开(公告)号：JPS63264437A

    公开(公告)日：1988-11-01

    申请号：JP7980787

    申请日：1987-04-02

    Applicant: SAGAMI CHEM RES

    Inventor： FUCHIGAMI TAKAMASA ,  ISHII YOSHIMITSU ,  URATA HISAO

    IPC: C07C53/21 ,  B01J23/58 ,  B01J31/20 ,  C07B61/00 ,  C07C51/00 ,  C07C51/10 ,  C07C57/58 ,  C07C59/21 ,  C07C59/88 ,  C07C67/00

    Abstract: PURPOSE:To readily obtain the titled compounds useful as a functional material, etc., such as physiologically active substance or surfactant, in good yield in one stage, by reacting an industrially readily available fluorine-containing alkyl iodide with CO and water using an inexpensive specific catalyst. CONSTITUTION:A fluorine-containing alkyl iodide expressed by formula I (R and R are H, halogen or polyfluorocarbon group; R -R are H, alkyl, aralkyl or aryl, provided that R and R , R and R , R and R or R , R and R or R together with carbon atom to which they are linked may form a ring) is reacted with CO and water in the presence of a cobalt salt, such as Co2(CO)8, rhodium catalyst, such as Rh6(CO)16, and a base, such as Ca(OH)2, and, as necessary, in the coexistence of a phase-transfer catalyst, such as a quaternary ammonium salt, in a solvent, such as tertbutanol, at 20-200 deg.C under

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