公开(公告)号：JPH1053589A

公开(公告)日：1998-02-24

申请号：JP30759296

申请日：1996-11-19

Applicant: SAGAMI CHEM RES

Inventor： TSUJI TOMOKO ,  YAMAGUCHI KOJI ,  YADA MIKA ,  KAMIMURA DAISUKE ,  YAMADA KAORU

IPC: A61K31/435 ,  A61P3/00 ,  A61P9/00 ,  A61P29/00 ,  A61P31/04 ,  A61P31/12 ,  A61P35/00 ,  A61P37/06 ,  A61P43/00 ,  C07D498/22

Abstract: PROBLEM TO BE SOLVED: To obtain the subject production inhibitor containing a specific zoanthamine compound or its salt as an active ingredient, capable of inhibiting the production of interleukin-6 and useful for preventing and treating diseases caused by the interleukin-6, etc. SOLUTION: This interleukin-6 production inhibitor contains a zoanthamine compound of the formula (R is H, OH, or R forms a single bond together with R ; R is H, or R forms a single bond together with R or R ; R is H, or R forms a single bond together with R or methylene group together with R ; R is H, or R forms oxo group together with R ; R is OH, or R forms oxo group together with R ; R is H, methyl, hydroxymethyl; R is methyl, or R forms methylene group together with R ; R and R are combined with each other to form oxo group) or its pharmaceutically permissible salt as an active ingredient. The interleukin-6 inhibitor can inhibit the production of the interleukin-6, and thereby is useful for medicines for preventing and treating diseases caused by the interleukin-6, and further for bone resorption-inhibiting medicines, osteoporosis medicines, etc.