公开(公告)号：WO2010061382A3

公开(公告)日：2010-08-19

申请号：PCT/IL2009001099

申请日：2009-11-23

Applicant: SAPHIER MAGAL

Inventor： SAPHIER MAGAL

IPC: C07C201/08 ,  C07C213/02 ,  C07C215/76

CPC classification number: C07C201/08 ,  C07B43/02 ,  C07C209/02 ,  C07C209/66 ,  C07C213/02 ,  C07C227/16 ,  C07C211/46 ,  C07C215/76 ,  C07C229/36 ,  C07C205/06 ,  C07C205/12 ,  C07C205/22

Abstract: A process for preparing a substituted aromatic compound, comprising combining an aromatic compound and cuprous (Cu+) ions in a reaction vessel in an essentially oxygen-free environment, and adding to said reaction vessel a source of an electrophile or a nucleophile substituent, to form an aromatic compound product which is ring-substituted with said electrophile or nucleophile at a position which was originally occupied by hydrogen, and isolating the substituted aromatic compound from the reaction mixture.

Abstract translation: 一种制备取代的芳族化合物的方法，包括在基本上无氧的环境下将芳族化合物和亚铜（Cu +）离子结合在反应容器中，并向所述反应容器中加入亲电试剂或亲核取代基的来源以形成 在最初被氢占据的位置上被所述亲电试剂或亲核试剂环取代的芳族化合物产物，并从反应混合物中分离取代的芳族化合物。