公开(公告)号：WO2022036443A1

公开(公告)日：2022-02-24

申请号：PCT/CA2021/051134

申请日：2021-08-17

Applicant: SCI RESOURCE PLATFORM INC.

Inventor： FOUCHER, Daniel ,  CASCHERA, Alexander Gabriel ,  BEDARD, Joseph

IPC: C07F9/54 ,  A61L2/232 ,  C08K5/50 ,  C08K5/541

Abstract: The attachment and proliferation of antibiotic resistant, biofilm-forming bacteria to oft-handled material surfaces has emerged as a growing concern, particularly in the biomedical, healthcare and food packaging industries. UV-curable phosphoniums bearing benzophenone anchors have been synthesized with a variety of alkyl, aryl, and fluoroalkyl functional groups at phosphorus to probe their efficacy as thermally stable antimicrobial additives in plastics or as surface coatings. In an embodiment, a phosphonium compound having the following formula (I), has been synthesized: in which R is a phosphine group substituted with alkyl, aryl, substituted alkyl, substituted aryl, heteroalkyl or any combination thereof. These materials maintained the ability to kill biofilm-forming bacteria even after being subject to abrasion processes, demonstrating the potential to serve as long-term antimicrobial materials.