公开(公告)号：PT994102E

公开(公告)日：2003-06-30

申请号：PT99402495

申请日：1999-10-12

Applicant: SERVIER LAB

Inventor： LANGLOIS MICHEL ,  ALLAINMAT MONIQUE MATHE ,  DELAGRANGE PHILIPPE ,  RENARD PIERRE ,  BENNEJEAN CAROLINE ,  GALL MARIE LEFAS-LE

IPC: A61K31/16 ,  A61K31/165 ,  A61K31/17 ,  A61K31/335 ,  A61K31/343 ,  A61K31/352 ,  A61K31/353 ,  A61K31/38 ,  A61K31/381 ,  A61K31/395 ,  C07D339/00 ,  A61K31/4355 ,  A61K31/437 ,  A61P1/00 ,  A61P3/04 ,  A61P3/10 ,  A61P9/00 ,  A61P15/00 ,  A61P25/00 ,  A61P25/04 ,  A61P25/06 ,  A61P25/08 ,  A61P25/16 ,  A61P25/18 ,  A61P25/20 ,  A61P25/22 ,  A61P25/24 ,  A61P25/28 ,  A61P35/00 ,  A61P43/00 ,  C07C233/18 ,  C07C233/23 ,  C07C233/74 ,  C07C235/34 ,  C07C235/40 ,  C07C275/26 ,  C07D307/79 ,  C07D307/80 ,  C07D307/81 ,  C07D311/92 ,  C07D333/58 ,  C07D333/60 ,  C07D471/04 ,  C07D491/04 ,  C07D491/048 ,  C07D493/04

Abstract: Cycloalkene substituted cyclic derivatives (I) are new. Cycloalkene substituted cyclic derivatives of formula (I), their enantiomers, diastereoisomers and their acid or base addition salts are new. A = a group of formula (i) or (ii) (optionally substituted by Ra, ORa, OH, CORa, formyl, COORa, COOH or OCORa; Ra = 1-6C alkyl, 2-6C alkenyl, 2-6C alkynyl, 1-6C polyhaloalkyl, 3-8C cycloalkyl, 3-8C cycloalkyl-(1-6C) alkyl, 3-8C cycloalkenyl, 3-8C cycloalkenyl-(1-6C) alkyl (all optionally substituted with at least one OH, 1-6C alkoxy, 1-6C alkyl, 1-6C polyhaloalkyl, amino or halo), aryl, aryl-(1-6C) alkyl, heteroaryl or heteroaryl-(1-6C) alkyl; X, Y' = O, S or CH2; D' = benzene or naphthalene; a-d = single or double bond; Z = O, S, CH2 or NR ; R = H, 1-6C alkyl, aryl or aryl-(1-6C) alkyl; D'' = benzene or pyridine; R = H, halo, OH, SH, Ra, ORa, S(O)nRa or a (un)saturated 5- to 7-membered ring of formula (iii) (optionally substituted with at least one 1-6C alkyl, 1-6C alkoxy, carboxy, 1-6C alkoxycarbonyl, OH or =O); n = 0-2; E = O or -S(O)n-; G1, G2 = single bond, -(CH2)t- (optionally substituted with at least one OH, COOH, formyl, Ra, ORa, COORa, CORa or halo; p, q = 0-4; p + q = 1-4; B' = -NR aC(Q)R a, -NR aC(Q)NR aR a or -C(Q)NR aR a; R a-R a = H or Ra; Q = O or S; aryl = phenyl, naphthyl, biphenyl (all optionally substituted with at least one OH, 1-6C alkoxy, 1-6C alkyl, 1-6C polyhaloalkyl, CN, COOH, 1-6C alkoxycarbonyl, NO2, amino or halo); heteroaryl = 5- to 10-membered mono- or polycyclic aromatic ring containing 1-3 N, O or S (optionally substituted with at least one OH, 1-6C alkoxy, 1-6C alkyl, 1-6C polyhaloalkyl, CN, COOH, 1-6C alkoxycarbonyl, NO2, amino or halo); and provided that q = 0 and p = 4, or q = 4 and p = 0 do not apply, when A is naphthyl (optionally substituted with methoxy or methyl), G1 and G2 are single bonds and B' is a group of formula (iv) or NHCOCH3; that A is other than halo substituted naphthyl, when G1 is a single bond and p + q is 1; B' is other than urea, when A is indolyl substituted on position 2 with a group of formula (v); and that B' is other than CONH-aryl, when A is indolyl substituted on position 2 with carboxyl or alkoxycarbonyl, p is 1, q is 0 (p is 0 and q is 1) and G1 is single bond. A Independent claim is also included for the preparation of (I).

公开(公告)号：PT1047664E

公开(公告)日：2004-08-31

申请号：PT98959957

申请日：1998-12-11

Applicant: SERVIER LAB

Inventor： ANDRIEUX JEAN ,  LANGLOIS MICHEL ,  ALLAINMAT MONIQUE MATHE ,  DELAGRANGE PHILIPPE ,  RENARD PIERRE ,  BENNEJEAN CAROLINE ,  JELLIMANN CAROLE

IPC: C07D333/74 ,  A61K31/165 ,  A61K31/343 ,  A61K31/381 ,  A61K31/403 ,  A61P9/06 ,  A61P25/20 ,  A61P25/22 ,  A61P43/00 ,  C07C233/05 ,  C07C233/18 ,  C07C233/60 ,  C07C235/34 ,  C07C275/24 ,  C07C275/26 ,  C07D209/60 ,  C07D209/90 ,  C07D307/77 ,  C07D307/92 ,  C07D307/93 ,  C07D333/78

Abstract: The invention concerns compounds of formula (I) in which: A forms a tricyclic system of formula A1, A2, A3 or A4; R1 represents a hydrogen atom, an alkyl, hydroxy, alkoxy or oxo group; (R2)m and (R3)m' are such as defined in the description; n represents an integer such that 0