公开(公告)号：HRP20030078B1

公开(公告)日：2004-06-30

申请号：HRP20030078

申请日：2003-02-06

Applicant: SERVIER LAB

Inventor： PFEIFFER BRUNO ,  GINOT YVES-MICHEL ,  COQUEREL GURARD ,  BEILLES STUPHANE

IPC: A61K45/00 ,  A61K31/404 ,  A61K38/00 ,  A61P7/10 ,  A61P9/00 ,  A61P9/04 ,  A61P9/10 ,  A61P9/12 ,  A61P13/02 ,  A61P43/00 ,  B01D9/02 ,  C07D209/08 ,  C07D209/42 ,  C07K1/30 ,  C07K5/062

Abstract: A gamma crystalline form of the compound of formula (I): characterized by its powder X-ray diffraction data. Medicinal products containing the same which are useful as inhibitors of angiotensin I converting enzyme.

公开(公告)号：CZ301765B6

公开(公告)日：2010-06-16

申请号：CZ2003356

申请日：2001-07-06

Applicant: SERVIER LAB

Inventor： PFEIFFER BRUNO ,  GINOT YVES-MICHEL ,  COQUEREL GURARD ,  BEILLES STUPHANE

IPC: A61K9/20 ,  C07D209/42 ,  A61K31/404 ,  A61K38/00 ,  A61K38/55 ,  A61K45/00 ,  A61P7/10 ,  A61P9/00 ,  A61P9/04 ,  A61P9/10 ,  A61P9/12 ,  A61P13/02 ,  A61P43/00 ,  B01D9/02 ,  C07K1/30 ,  C07K5/062

Abstract: Vynález se týká zpusobu výroby .beta.-krystalické formy terc-butylaminové soli perindoprilu vzorce I spocívající v tom, že se roztok terc-butylaminové soli perindoprilu v dichlormethanu zahrívá k refluxu, potom se ochladí na 0.degree. C a získaná pevná fáze se oddelí filtrací.

公开(公告)号：HRP20030077A2

公开(公告)日：2003-04-30

申请号：HRP20030077

申请日：2003-02-06

Applicant: SERVIER LAB

Inventor： PFEIFFER BRUNO ,  GINOT YVES-MICHEL ,  COQUEREL GURARD ,  BEILLES STUPHANE

IPC: A61K31/404 ,  A61K45/00 ,  A61P7/10 ,  A61K38/00 ,  A61P9/00 ,  A61P9/04 ,  A61P9/12 ,  A61P13/02 ,  A61P43/00 ,  B01D9/02 ,  C07D209/42 ,  C07K1/30 ,  C07K5/02 ,  C07K5/06 ,  C07K5/062 ,  A61K31/475

Abstract: An alpha crystalline form of the compound of formula (I): characterized by its powder X-ray diffraction data. Medicinal products containing the same which are useful as inhibitors of angiotensin I converting enzyme.

公开(公告)号：HRP20030077B1

公开(公告)日：2011-07-31

申请号：HRP20030077

申请日：2003-02-06

Applicant: SERVIER LAB

Inventor： PFEIFFER BRUNO ,  GINOT YVES-MICHEL ,  COQUEREL GURARD ,  BEILLES STUPHANE

IPC: A61K38/00 ,  A61K31/404 ,  C07D209/42 ,  A61K31/475 ,  A61K45/00 ,  A61P7/10 ,  A61P9/00 ,  A61P9/04 ,  A61P9/12 ,  A61P13/02 ,  A61P43/00 ,  B01D9/02 ,  C07K1/30 ,  C07K5/02 ,  C07K5/06 ,  C07K5/062

Abstract: An alpha crystalline form of the compound of formula (I): characterized by its powder X-ray diffraction data. Medicinal products containing the same which are useful as inhibitors of angiotensin I converting enzyme.

公开(公告)号：HRP20030079A2

公开(公告)日：2003-04-30

申请号：HRP20030079

申请日：2003-02-06

Applicant: SERVIER LAB

Inventor： PFEIFFER BRUNO ,  GINOT YVES-MICHEL ,  COQUEREL GURARD ,  BEILLES STUPHANE

IPC: A61K9/20 ,  A61K31/404 ,  A61K38/00 ,  A61K38/55 ,  A61K45/00 ,  A61P7/10 ,  A61P9/00 ,  A61P9/04 ,  A61P9/10 ,  A61P9/12 ,  A61P13/02 ,  A61P43/00 ,  B01D9/02 ,  C07D209/42 ,  C07K1/30 ,  C07K5/062

Abstract: beta -crystalline form of perindopril tertiary butylamine salt (I). Beta crystalline form of perindopril tertiary butylamine salt (I) having a given X-ray powder diffraction pattern. [Image] Independent claims are also included for: (1) preparation of beta -crystalline (I); and (2) compositions containing (I). ACTIVITY : Cardiant. MECHANISM OF ACTION : Angiotensin I converting enzyme inhibitor.

公开(公告)号：HRP20030078A2

公开(公告)日：2003-04-30

申请号：HRP20030078

申请日：2003-02-06

Applicant: SERVIER LAB

Inventor： PFEIFFER BRUNO ,  GINOT YVES-MICHEL ,  COQUEREL GURARD ,  BEILLES STUPHANE

IPC: A61K45/00 ,  A61K31/404 ,  A61K38/00 ,  A61P7/10 ,  A61P9/00 ,  A61P9/04 ,  A61P9/10 ,  A61P9/12 ,  A61P13/02 ,  A61P43/00 ,  B01D9/02 ,  C07D209/08 ,  C07D209/42 ,  C07K1/30 ,  C07K5/062

Abstract: A gamma crystalline form of the compound of formula (I): characterized by its powder X-ray diffraction data. Medicinal products containing the same which are useful as inhibitors of angiotensin I converting enzyme.

公开(公告)号：HRP20060361A8

公开(公告)日：2008-07-31

申请号：HRP20060361

申请日：2006-10-20

Applicant: SERVIER LAB

Inventor： PFEIFFER BRUNO ,  GINOT YVES-MICHEL ,  COQUEREL GURARD ,  BEILLES STUPHANE

IPC: A61K9/20 ,  C07D209/42 ,  A61K31/404 ,  A61K38/00 ,  A61K38/55 ,  A61K45/00 ,  A61P7/10 ,  A61P9/00 ,  A61P9/04 ,  A61P9/10 ,  A61P9/12 ,  A61P13/02 ,  A61P43/00 ,  B01D9/02 ,  C07K1/30 ,  C07K5/062

Abstract: beta -crystalline form of perindopril tertiary butylamine salt (I). Beta crystalline form of perindopril tertiary butylamine salt (I) having a given X-ray powder diffraction pattern. [Image] Independent claims are also included for: (1) preparation of beta -crystalline (I); and (2) compositions containing (I). ACTIVITY : Cardiant. MECHANISM OF ACTION : Angiotensin I converting enzyme inhibitor.

公开(公告)号：HRP20030079B1

公开(公告)日：2007-12-31

申请号：HRP20030079

申请日：2003-02-06

Applicant: SERVIER LAB

Inventor： PFEIFFER BRUNO ,  GINOT YVES-MICHEL ,  COQUEREL GURARD ,  BEILLES STUPHANE

IPC: A61K9/20 ,  C07D209/42 ,  A61K31/404 ,  A61K38/00 ,  A61K38/55 ,  A61K45/00 ,  A61P7/10 ,  A61P9/00 ,  A61P9/04 ,  A61P9/10 ,  A61P9/12 ,  A61P13/02 ,  A61P43/00 ,  B01D9/02 ,  C07K1/30 ,  C07K5/062

Abstract: beta -crystalline form of perindopril tertiary butylamine salt (I). Beta crystalline form of perindopril tertiary butylamine salt (I) having a given X-ray powder diffraction pattern. [Image] Independent claims are also included for: (1) preparation of beta -crystalline (I); and (2) compositions containing (I). ACTIVITY : Cardiant. MECHANISM OF ACTION : Angiotensin I converting enzyme inhibitor.

公开(公告)号：CZ297672B6

公开(公告)日：2007-02-28

申请号：CZ2003357

申请日：2001-07-06

Applicant: SERVIER LAB

Inventor： PFEIFFER BRUNO ,  GINOT YVES-MICHEL ,  COQUEREL GURARD ,  BEILLES STUPHANE

IPC: A61K38/00 ,  C07D209/42 ,  A61K31/404 ,  A61K45/00 ,  A61P7/10 ,  A61P9/00 ,  A61P9/04 ,  A61P9/12 ,  A61P13/02 ,  A61P43/00 ,  B01D9/02 ,  C07K1/30 ,  C07K5/02 ,  C07K5/06 ,  C07K5/062

Abstract: Rešení se týká .alfa.-krystalické formy slouceniny vzorce I charakterizovanou svým diagramem práškové rentgenové difrakce. Tato forma je využitelná pri príprave léciv.

公开(公告)号：HRP20030079B8

公开(公告)日：2008-09-30

申请号：HRP20030079

申请日：2003-02-06

Applicant: SERVIER LAB

Inventor： PFEIFFER BRUNO ,  GINOT YVES-MICHEL ,  COQUEREL GURARD ,  BEILLES STUPHANE

IPC: A61K9/20 ,  C07D209/42 ,  A61K31/404 ,  A61K38/00 ,  A61K38/55 ,  A61K45/00 ,  A61P7/10 ,  A61P9/00 ,  A61P9/04 ,  A61P9/10 ,  A61P9/12 ,  A61P13/02 ,  A61P43/00 ,  B01D9/02 ,  C07K1/30 ,  C07K5/062

Abstract: beta -crystalline form of perindopril tertiary butylamine salt (I). Beta crystalline form of perindopril tertiary butylamine salt (I) having a given X-ray powder diffraction pattern. [Image] Independent claims are also included for: (1) preparation of beta -crystalline (I); and (2) compositions containing (I). ACTIVITY : Cardiant. MECHANISM OF ACTION : Angiotensin I converting enzyme inhibitor.