公开(公告)号：JP2002179652A

公开(公告)日：2002-06-26

申请号：JP2001319183

申请日：2001-10-17

Applicant: SERVIER LAB

Inventor： METH-COHN OTTO ,  YU CHU-YI ,  LESTAGE PIERRE ,  LEBRUN MARIE-CECILE ,  CAIGNARD DANIEL-HENRI ,  RENARD PIERRE

IPC: C07D211/00 ,  A61K31/435 ,  A61K31/44 ,  A61K31/4402 ,  A61K31/4418 ,  A61K31/4425 ,  A61K31/4439 ,  A61K31/445 ,  A61K31/4458 ,  A61K31/451 ,  A61K31/452 ,  A61K31/5377 ,  A61P25/00 ,  A61P25/02 ,  A61P25/04 ,  A61P25/16 ,  A61P25/28 ,  B01J23/42 ,  C07B61/00 ,  C07D211/22 ,  C07D211/32 ,  C07D213/30 ,  C07D213/36 ,  C07D213/38 ,  C07D213/50 ,  C07D401/06

Abstract: PROBLEM TO BE SOLVED: To obtain a compound capable of resisting dysgnosia with aging and ameliorating a recognition process, having analgesic characteristics. SOLUTION: This compound is represented by formula (I) [A is pyridine, or the like; R2 is hydrogen atom, or the like; R3 is hydroxy group, or the like; R4 is phenyl group, or the like; R1 is hydrogen atom, or the like; R5 is a five- or six-membered ring which may contain a nitrogen atom combined with the ring A and another hetero atom selected from sulfur, oxygen and nitrogen; R6 is hydrogen atom, or the like], its enantiomer, a diastereoisomer, pharmacologically acceptable acid, base or their addition salts. The method for producing the compound is provided. The medicine composition comprises the compound.

公开(公告)号：WO2008049997A8

公开(公告)日：2009-05-22

申请号：PCT/FR2007001708

申请日：2007-10-17

Applicant: SERVIER LAB ,  MARCHAND PASCAL ,  BABONNEAU VINCENT ,  PIESSARD SYLVIE ,  DUFLOS MURIEL ,  BOUTIN JEAN ALBERT ,  AUDINOT VALERIE ,  DELAGRANGE PHILIPPE ,  CAIGNARD DANIEL-HENRI

Inventor： MARCHAND PASCAL ,  BABONNEAU VINCENT ,  PIESSARD SYLVIE ,  DUFLOS MURIEL ,  BOUTIN JEAN ALBERT ,  AUDINOT VALERIE ,  DELAGRANGE PHILIPPE ,  CAIGNARD DANIEL-HENRI

IPC: C07D209/32 ,  A61K31/4045

CPC classification number: C07D209/14

Abstract: Compounds of formula (I): in which: R1 is an alkyl, cycloalkyl or cycloalkylalkyl group, R2 and R3 form, together with the nitrogen atom which bears them, a heterocycle comprising from 5 to 8 ring members, and n is 2 to 6; medicaments.

Abstract translation: 式（I）化合物：其中：R1是烷基，环烷基或环烷基烷基，R2和R3与带有它们的氮原子一起形成包含5至8个环成员的杂环，n是2至6 ; 药物。

公开(公告)号：WO2008049996A3

公开(公告)日：2008-06-19

申请号：PCT/FR2007001707

申请日：2007-10-17

Applicant: SERVIER LAB ,  MARCHAND PASCAL ,  BABONNEAU VINCENT ,  PIESSARD SYLVIE ,  DUFLOS MURIEL ,  BOUTIN JEAN ALBERT ,  AUDINOT VALERIE ,  DELAGRANGE PHILIPPE ,  CAIGNARD DANIEL-HENRI

Inventor： MARCHAND PASCAL ,  BABONNEAU VINCENT ,  PIESSARD SYLVIE ,  DUFLOS MURIEL ,  BOUTIN JEAN ALBERT ,  AUDINOT VALERIE ,  DELAGRANGE PHILIPPE ,  CAIGNARD DANIEL-HENRI

IPC: C07D209/42 ,  A61K31/404 ,  A61P1/00 ,  A61P9/00 ,  A61P15/00 ,  A61P25/00 ,  A61P35/00

CPC classification number: C07D209/42

Abstract: The invention relates to compounds of formula (I), in which: R is an alkyl, cycloalkyl or cycloalkylalkyl group, R is a linear or branched (C 1 -C 6 ) alkyl group, and n is 1 to 6, and to the use thereof for the treatment of disorders in the melatoninergic system, such as sleep disorders, stress, anxiety, cardiovascular pathologies, etc..

Abstract translation: 本发明涉及式（I）化合物，其中：R是烷基，环烷基或环烷基烷基，R是直链或支链（C 1 -C 6 - ）烷基，n为1至6，以及其用于治疗褪黑激素系统中的疾病的用途，例如睡眠障碍，应激，焦虑，心血管病变等。

公开(公告)号：WO2009022063A3

公开(公告)日：2009-04-16

申请号：PCT/FR2008000932

申请日：2008-07-01

Applicant: SERVIER LAB ,  YOUS SAID ,  ETTAOUSSI MOHAMED ,  SABAOUNI AHMED ,  BERTHELOT PASCAL ,  SPEDDING MICHAEL ,  DELAGRANGE PHILIPPE ,  CAIGNARD DANIEL-HENRI ,  MILLAN MARK

Inventor： YOUS SAID ,  ETTAOUSSI MOHAMED ,  SABAOUNI AHMED ,  BERTHELOT PASCAL ,  SPEDDING MICHAEL ,  DELAGRANGE PHILIPPE ,  CAIGNARD DANIEL-HENRI ,  MILLAN MARK

IPC: C07C251/48 ,  A61K31/165 ,  A61P25/00

CPC classification number: C07C251/48

Abstract: Compounds of formula (I): in which: R1 is an alkyl, alkenyl, haloalkyl, polyhaloalkyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heteroaryl or heteroarylalkyl, and X is an N-OR2 group in which R2 is a hydrogen atom or an alkyl group. Medicaments.

Abstract translation: 式（I）化合物：其中：R 1是烷基，链烯基，卤代烷基，多卤代烷基，环烷基，环烷基烷基，芳基，芳基烷基，杂芳基或杂芳基烷基，X是N-OR 2基团，其中R 2是氢原子或 烷基。 药物。

公开(公告)号：WO2004048340A8

公开(公告)日：2005-07-07

申请号：PCT/EP0314841

申请日：2003-11-26

Applicant: SHANGHAI INST MATERIA MEDICA ,  SERVIER LAB ,  QIN GUO-WEI ,  TANG XI-CAN ,  WANG RUI ,  ZHOU TIAN-XI ,  LESTAGE PIERRE ,  CAIGNARD DANIEL-HENRI ,  RENARD PIERRE

Inventor： QIN GUO-WEI ,  TANG XI-CAN ,  WANG RUI ,  ZHOU TIAN-XI ,  LESTAGE PIERRE ,  CAIGNARD DANIEL-HENRI ,  RENARD PIERRE

IPC: C07D221/28 ,  A61K31/485 ,  C07D489/00

CPC classification number: C07D221/28

Abstract: The invention relates to sinomenine and compounds thereof and also to compounds of formula (I), wherein R1 represents an alkyl group; R2 represents a hydrogen atom or an alkylcarbonyl group, an haloalkylcarbonyl group or an arylcarbonyl; Y represents a group (II), (III) or (IV); R3 ,R4, R'4, R5, R'5 and R6 are as defined in the description; and X represents a halogen atom. Medicaments.

Abstract translation: 本发明涉及青藤碱及其化合物，还涉及式（I）化合物，其中R 1表示烷基; R2表示氢原子或烷基羰基，卤代烷基羰基或芳基羰基; Y代表（II），（III）或（IV）; R3，R4，R'4，R5，R'5和R6如说明书中所定义; X表示卤素原子。 药物。

公开(公告)号：WO2007101935A3

公开(公告)日：2008-02-21

申请号：PCT/FR2007000384

申请日：2007-03-05

Applicant: SERVIER LAB ,  HURTEVENT AURELIE ,  L HELGOUAL CH JEAN-MARTIAL ,  CARATO PASCAL ,  LEBEGUE NICOLAS ,  LECLERC VERONIQUE ,  LE NAOUR MORGAN ,  BERTHELOT PASCAL ,  DACQUET CATHERINE ,  KTORZA ALAIN ,  CAIGNARD DANIEL-HENRI

Inventor： HURTEVENT AURELIE ,  L HELGOUAL CH JEAN-MARTIAL ,  CARATO PASCAL ,  LEBEGUE NICOLAS ,  LECLERC VERONIQUE ,  LE NAOUR MORGAN ,  BERTHELOT PASCAL ,  DACQUET CATHERINE ,  KTORZA ALAIN ,  CAIGNARD DANIEL-HENRI

IPC: C07D277/68 ,  A61K31/428 ,  A61P3/04 ,  A61P3/06 ,  A61P3/10

CPC classification number: C07D277/68

Abstract: The invention relates to compounds of formula (I) wherein R 1 represents a cycloalkyl group (C 3 -C 8 ), R 2 represents a group of formula (II) as defined in the description, X represents an oxygen atom, or an N-OR' group wherein R' represents a hydrogen atom, a straight or branched alkyl group (C 1 -C 6 ), or a straight or branched aryl or arylalkyl group (C 1 -C 6 ) as hypoglycemic or hypolipidemic agents.

Abstract translation: 本发明涉及其中R 1表示环烷基（C 3 -C 8）的式（I）化合物， 2表示在说明书中定义的式（II）的基团，X表示氧原子或其中R'表示氢原子，直链或支链烷基（C C 1 -C 6）或直链或支链的芳基或芳基烷基（C 1 -C 6 -C 6）作为低血糖 或降血脂药。

公开(公告)号：WO2006079720A8

公开(公告)日：2007-12-13

申请号：PCT/FR2006000175

申请日：2006-01-26

Applicant: SERVIER LAB ,  HURTEVENT AURELIE ,  L HELGOUAL CH JEAN-MARTIAL ,  CARATO PASCAL ,  LEBEGUE NICOLAS ,  LECLERC VERONIQUE ,  BERTHELOT PASCAL ,  DACQUET CATHERINE ,  KTORZA ALAIN ,  CAIGNARD DANIEL-HENRI

Inventor： HURTEVENT AURELIE ,  L HELGOUAL CH JEAN-MARTIAL ,  CARATO PASCAL ,  LEBEGUE NICOLAS ,  LECLERC VERONIQUE ,  BERTHELOT PASCAL ,  DACQUET CATHERINE ,  KTORZA ALAIN ,  CAIGNARD DANIEL-HENRI

IPC: C07D279/16 ,  A61K31/538 ,  A61K31/5415 ,  A61P3/06 ,  A61P3/10 ,  C07D265/36

CPC classification number: C07D279/16 ,  C07D265/36

Abstract: The invention concerns compounds of formula (I) and their use as hypoglycaemic or hypolipide

Abstract translation: 本发明涉及式（I）的化合物及其作为低血糖或降血脂的用途

公开(公告)号：WO2005099694A8

公开(公告)日：2006-11-09

申请号：PCT/FR2005000755

申请日：2005-03-30

Applicant: SERVIER LAB ,  CENTRE NAT RECH SCIENT ,  CASTEILLA LOUIS ,  PENICAUD LUC ,  BERTHELOT PASCAL ,  DACQUET CATHERINE ,  CAIGNARD DANIEL-HENRI

Inventor： CASTEILLA LOUIS ,  PENICAUD LUC ,  BERTHELOT PASCAL ,  DACQUET CATHERINE ,  CAIGNARD DANIEL-HENRI

IPC: A61K31/15 ,  A61K9/20 ,  A61K31/428

CPC classification number: A61K31/428 ,  A61K9/2018 ,  A61K9/2059 ,  A61K31/15

Abstract: The invention concerns a combination comprising a derivative promoting lipid and carbohydrate metabolism of the body and an antioxidant. The invention is applicable to medicines.

Abstract translation: 本发明涉及包含促进脂肪的脂质和身体的碳水化合物代谢与抗氧化剂的组合。 本发明适用于药物。

公开(公告)号：WO2009022066A3

公开(公告)日：2009-04-16

申请号：PCT/FR2008000935

申请日：2008-07-01

Applicant: SERVIER LAB ,  YOUS SAID ,  ETTAOUSSI MOHAMED ,  SABAOUNI AHMED ,  BERTHELOT PASCAL ,  SPEDDING MICHAEL ,  DELAGRANGE PHILIPPE ,  CAIGNARD DANIEL-HENRI ,  MILLAN MARK

Inventor： YOUS SAID ,  ETTAOUSSI MOHAMED ,  SABAOUNI AHMED ,  BERTHELOT PASCAL ,  SPEDDING MICHAEL ,  DELAGRANGE PHILIPPE ,  CAIGNARD DANIEL-HENRI ,  MILLAN MARK

IPC: C07C233/18 ,  A61K31/165 ,  A61P25/00

CPC classification number: C07C233/18

Abstract: Compound of formula (I): Medicaments.

Abstract translation: 式（I）化合物：药物。

公开(公告)号：WO2008081096A3

公开(公告)日：2008-08-21

申请号：PCT/FR2007001957

申请日：2007-11-29

Applicant: SERVIER LAB ,  GREE RENE ,  LIUTKUS MELANIE ,  CAIJO FREDERIC ,  BRIOCHE JULIEN ,  JENNEQUIN THOMAS ,  DACQUET CATHERINE ,  KTORZA ALAIN ,  CAIGNARD DANIEL-HENRI

Inventor： GREE RENE ,  LIUTKUS MELANIE ,  CAIJO FREDERIC ,  BRIOCHE JULIEN ,  JENNEQUIN THOMAS ,  DACQUET CATHERINE ,  KTORZA ALAIN ,  CAIGNARD DANIEL-HENRI

IPC: C07D215/227 ,  A61K31/47 ,  A61P3/04 ,  A61P3/06 ,  A61P3/10

CPC classification number: C07D215/227

Abstract: The invention relates to compounds of the formula (I) in which : R 1 is an alkyl group substituted or unsubstituted with one or more COOR 3 or NR4R 5 groups; R 2 is a substituted or unsubstituted phenyl group; and n is 0, 1, 2, 3, 4, 5, 6, 7 or 8. Use in drugs.

Abstract translation: 本发明涉及式（I）化合物，其中：R 1是被一个或多个COOR 3或NR 4 R 5取代或未取代的烷基， / SUB>组 R 2是取代或未取代的苯基; 并且n为0,1,2,3,4,5,6,7或8.用于药物中。