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公开(公告)号：US20210308676A1
公开(公告)日：2021-10-07
申请号：US16769103
申请日：2018-12-21
Applicant: SHENZHEN INSTITUTES OF ADVANCED TECHNOLOGY
Inventor： Hairong ZHENG , Fei LI , Feiyan CAI , Long MENG , Yang XIAO , Fei YAN
Abstract: A microfluidic system, including: a container, an ultrasound transmitter assembly, and a phononic crystal plate. The container is configured to accommodate a solution containing microparticles. The ultrasound transmitter assembly is configured to transmit ultrasonic waves to the phononic crystal plate, where the ultrasonic waves have a frequency which is the same as a resonance frequency of the phononic crystal plate. The phononic crystal plate is placed in the solution, and configured to generate a local acoustic field on a surface of the phononic crystal plate under excitation of the ultrasonic waves, and induce an acoustic microstreaming vortex to generate an acoustic streaming shear stress on the microparticles. The phononic crystal plate defines therein cavities, the respective cavities are arranged periodically in the phononic crystal plate, and all the respective cavities are filled with gas.
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2.发明公开公开(公告)号：US20230314377A1
公开(公告)日：2023-10-05
申请号：US18332697
申请日：2023-06-09
Inventor： Long MENG , Wei ZHOU , Hairong ZHENG , Lili NIU , Zhengrong LIN , Benxian PENG , Farooq UMAR , Yingjian CUI
CPC classification number: G01N29/022 , H03H9/25 , H03H9/02574 , H03H3/10
Abstract: The present invention discloses a real-time ultrasonic stimulation electric signal recording chip and a preparation method thereof, where the preparation method includes the following steps: S1 manufacturing an interdigital electrode on a piezoelectric substrate to obtain a surface acoustic wave chip, and manufacturing a recording electrode and an electrode lead; S2, manufacturing an insulation protection layer on the chip obtained in the S1, and processing the insulation protection layer to form the recording electrode, so as to obtain a chip combining the interdigital electrode and the recording electrode; S3, preparing a PDMS cavity; and S4, bonding the PDMS cavity prepared in the S3 and the chip obtained in the S2. In the present invention, combining the interdigital electrode generating a surface acoustic wave ultrasound with a multi-channel recording electrode, such that real-time recording of a multi-channel electric signal under ultrasonic stimulation is achieved.
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3.发明申请公开(公告)号：US20180369815A1
公开(公告)日：2018-12-27
申请号：US15742491
申请日：2015-10-10
Inventor： Hairong ZHENG , Fwi LI , Felyan CAI , Long MENG , Chen WANG , Chengxiang ZHANG , Weibao QIU , Yongchuan LI , Fei YAN , Lili NIU , Liufeng GENG , Chaowei XU
CPC classification number: B01L3/502761 , B01L3/502715 , B01L3/50273 , B01L3/502792 , B01L2200/0647 , B01L2200/0652 , B01L2300/06 , B01L2300/08 , B01L2300/0809 , B01L2400/0436 , B01L2400/0439 , B01L2400/0496 , C12N13/00 , G01N2015/0038 , G01N2015/1006
Abstract: Disclosed is a microfluidic system based on an artificially structured acoustic field, comprising a microcavity and a ultrasonic emission device, wherein the microcavity is used to accommodate a solution containing particles, the ultrasonic emission device is used to emit ultrasound, and characterized in further comprising a phononic crystal plate placed in the microcavity, wherein the phononic crystal plate has an artificial cycle structure, and is used to modulate the acoustic field so as to control the particles. Also disclosed is a method of controlling microfluid particles based on an artificially structured acoustic field. In the particular embodiments, since a microcavity, an ultrasonic emission device and a phononic crystal plate are comprised, the ultrasonic emission device is used to emit ultrasound, and the phononic crystal plate has an artificial cycle structure, and is used to modulate the acoustic field so as to control the particles. The method provides a new means for drug delivery, and offers technical support for drug research and development.
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Patent Agency Ranking
公开(公告)号：US20230293914A1
公开(公告)日：2023-09-21
申请号：US18325982
申请日：2023-05-30
Inventor： Hairong ZHENG , Wei ZHOU , Long MENG , Lili NIU , Zhengrong LIN , Xiaowei HUANG , Junjie ZOU
CPC classification number: A61N7/00 , A61B8/54 , A61N2007/0026
Abstract: The present application provides an ultrasonic wake-up system. The system includes an ultrasonic imaging device, an ultrasound stimulation device, and an ultrasound stimulation effect evaluation device, and acquires an ultrasonic image of a target object through the ultrasonic imaging device, transmits an ultrasound to the target object based on the ultrasonic image through the ultrasound stimulation device, and adjusts the transmitted ultrasound required through the ultrasound stimulation effect evaluation device. Therefore, peripheral nerves are accurately stimulated, an uplink reticular wake-up system is activated, so as to wake up patients with disorders of consciousness.
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公开(公告)号：US20170291044A1
公开(公告)日：2017-10-12
申请号：US15630623
申请日：2017-06-22
Inventor： Hairong ZHENG , Lili NIU , Congzhi WANG , Ming QIAN , Yang XIAO , Long MENG
CPC classification number: A61N7/02 , A61B5/0042 , A61B5/04001 , A61B5/0484 , A61B5/055 , A61B5/4836 , A61B5/7239 , A61B2562/0209 , A61B2562/046 , A61N2007/0026 , A61N2007/0052 , A61N2007/0073 , A61N2007/0082 , G16H50/50
Abstract: An ultrasound deep brain stimulation method and system, the ultrasound deep brain stimulation method comprises: medically imaging a head of an animal or a human being, to generate image data; creating a head 3D digital model according to the image data; creating a 3D digital model of an ultrasound transducer array according to structure, density and acoustic parameters information of the ultrasound transducer array; generating a first ultrasound transmitting sequence according to the head 3D digital model, the 3D digital model of the ultrasound transducer array, structure, density and acoustic parameters of the skull and brain tissues, and structure, density and acoustic parameters of the ultrasound transducer array; and controlling the ultrasound transducer array to transmit ultrasound waves in accordance with the first ultrasound transmitting sequence, to implement ultrasound deep brain stimulation to the brain nucleus to be stimulated. By the use of the present invention, ultrasound can noninvasively passes through the skull to be focused in a deep brain region. By the use of different ultrasound transmitting sequences, ultrasound neuromodulation can be realized, and research on an action mechanism for the ultrasound neuromodulation can be performed.
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6.发明公开公开(公告)号：US20240150748A1
公开(公告)日：2024-05-09
申请号：US18543140
申请日：2023-12-18
Inventor： Long MENG , Xiufang LIU , Hairong ZHENG , Lili NIU , Ning RONG
Abstract: Provided is an acoustic microfluidic system for cell fusion, a preparation method therefor and use thereof, which relates to the technical field of cell fusion. The acoustic microfluidic system of the present invention comprises a signal generator, a power amplifier, a PDMS cavity, a micro-injection pump, a pipeline, an EP tube, a cell recovery container, and a bulk wave transducer/surface acoustic wave transducer. The side wall/bottom of the PDMS cavity is provided with identical microporous structures disposed in a staggered manner The system of the present invention has the advantages of extremely low heat production quantity, simple operation, high repeatability and strong stability, and is suitable for the fusion of homologous cells and non-homologous cells. The system is not only suitable for the fusion of two cells, but also for the fusion of a plurality of cells, and can be widely applied to various types of cells.
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公开(公告)号：US20220033853A1
公开(公告)日：2022-02-03
申请号：US17297067
申请日：2018-07-26
Applicant: SHENZHEN INSTITUTES OF ADVANCED TECHNOLOGY
Inventor： Hairong ZHENG , Long MENG , Congzhi WANG , Xiufang LIU , Yuchen WANG , Wei ZHOU , Lili NIU , Xiaowei HUANG
Abstract: The gene transfection system includes an acoustothermal module and a signal generating module; the acoustothermal module includes a piezoelectric substrate, an acoustothermal chip arranged on the piezoelectric substrate and N sound-absorbing vessels arranged on the acoustothermal chip and used for cultivating recipient cells, and N is an integer greater than or equal to 1; the signal generating module is used to output basic frequency signals; the acoustothermal chip is used to convert the basic frequency signal to an acoustic wave signal, establish a temperature gradient field with the acoustic wave signal, and control the temperature of the recipient cell in the sound-absorbing vessels with the temperature gradient field, so that the pores are opened on the membranes of the recipient cell, and the nucleic acids or other substances can go into the cells through these pores.
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公开(公告)号：US20190321229A1
公开(公告)日：2019-10-24
申请号：US16474612
申请日：2017-02-08
Inventor： Hairong ZHENG , Zhengrong LIN , Lili NIU , Long MENG , Wei ZHOU , Xiaowei HUANG , Kaiyue WANG
Abstract: Disclosed is an ultrasonic wave generation device for hearing recovery treatment, including an ultrasonic wave generation part. The ultrasonic wave generation part comprises a reference time-delay determination module, an emission sequence parameter determination module and an ultrasonic transducer module. The ultrasonic transducer module is used for emitting actual ultrasonic waves, and the efficiency and precision are improved by focusing by means of a plurality of array elements.
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