公开(公告)号：US20250031975A1

公开(公告)日：2025-01-30

申请号：US18836155

申请日：2022-01-19

Applicant: SHENZHEN INSTITUTES OF ADVANCED TECHNOLOGY

Inventor： Lijuan Zhang ,  Chao Zou ,  Siqi Cai ,  Shihui Zhou ,  Yang Zhou ,  Hairong Zheng ,  Xin Liu

IPC: A61B5/01 ,  G01K11/00

Abstract: A temperature measuring method and apparatus based on creatine chemical exchange saturation transfer (CEST) imaging. The method comprises the following steps: (1) performing creatine CEST imaging on a creatine phantom, and analyzing a chemical shift of creatine relative to water in the creatine phantom; (2) fitting a mathematical relation between the chemical shift of the creatine relative to water and the temperature; and (3) performing CEST imaging on creatine in a sample, and calculating the temperature according to the mathematical relation, fitted in step (2), between the chemical shift of the creatine relative to water and the temperature. In the temperature measuring method, the creatine is taken as an endogenous reference, and highly-spatial-resolution, highly-sensitive, and non-invasive absolute temperature measurement can be implemented by means of temperature dependence of a CEST effect of Cr and water.