公开(公告)号：US20240398999A1

公开(公告)日：2024-12-05

申请号：US18326899

申请日：2023-05-31

Applicant: SHENZHEN INSTITUTES OF ADVANCED TECHNOLOGY CHINESE ACADEMY OF SCIENCES ,  THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY

Inventor： Lintao CAI ,  Xing YANG ,  Ping GONG ,  Pengfei ZHANG ,  Benzhong TANG ,  Tsz Kin KWOK ,  Ting YANG ,  Qiqi LIU ,  Xiuwen ZHANG ,  Xinghua YU ,  Luo HAI

IPC: A61K49/00 ,  A61K41/00 ,  A61P35/00

Abstract: The present invention belongs to the field of nanomedicine, and provides a DC biomimetic membrane nanoparticle loaded with an NIR-II AIE dye, a preparation method therefor and use thereof. The DC biomimetic membrane nanoparticle loaded with the NIR-II AIE dye comprises a DC membrane and an NIR-II AIE dye loaded therein, wherein the NIR-II AIE dye has photothermal characteristics. The DC biomimetic membrane nanoparticle loaded with the NIR-II AIE dye provided by the present invention not only solves the problem that the NIR-II AIE dye is poor in water solubility and limited in fluorescence imaging, but also increases the enrichment efficiency of the NIR-II AIE dye coated by the DC membrane at a tumor site and successfully activates the activity of T cells in vivo.

公开(公告)号：US20250038393A1

公开(公告)日：2025-01-30

申请号：US18911015

申请日：2024-10-09

Applicant: SHENZHEN INSTITUTES OF ADVANCED TECHNOLOGY

Inventor： Hairong ZHENG ,  Xinwei RONG ,  Ye LI ,  Jiasheng WANG ,  Jifeng CHEN ,  Xing YANG

IPC: H01P5/18 ,  G01R23/16

Abstract: The invention relates to a directional coupler, coupling high power and low power is used to replace existing two high-power directional couplers, thus reducing the cost and reducing the insertion loss of high-power radio frequency channels. The directional coupler cooperates with a control conditioning board, a splitter, a multi-path radio frequency power amplifier and a combiner to form the radio frequency power amplifier system, and the system is connected to a spectrometer; on one hand, by using a standard signal output by the spectrometer and a feedback signal of the directional coupler, nonlinearity caused by the power amplifier is corrected to achieve magnet-free linear radio frequency power amplification and anomaly protection; and on the other hand, the spectrometer can be used for monitoring the output power of the directional coupler and monitoring antenna matching, so as to provide dual protection for the radio frequency power amplifier system.