公开(公告)号：US20200309885A1

公开(公告)日：2020-10-01

申请号：US16309351

申请日：2017-12-29

Applicant: SHENZHEN INSTITUTES OF ADVANCED TECHNOLOGY

Inventor： Yin WU ,  Hairong ZHENG ,  Xin LIU

IPC: G01R33/56

Abstract: Provided is a method for measuring pH. Using amide protons as an endogenous contrast agent, a chemical exchange saturation transfer effect ratio R of amide protons corresponding to a pH-known amide proton solution under different saturation powers is measured by the method, then a function relation between pH and R is established according to different pH-known amide proton solutions and the corresponding measured R thereto, and finally the desired pH is calculated according to experimentally measured Ri and the function relation. The method can eliminate the impact of concentration and does not require any estimation or measurement of the parameters such as the concentration of exchangeable protons, the longitudinal relaxation time of water, etc., and therefore can measure pH more accurately, conveniently and non-invasively.