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公开(公告)号：US20240365760A1
公开(公告)日：2024-11-07
申请号：US18650088
申请日：2024-04-30
IPC: A01K67/0276 , C12Q1/686 , C12Q1/6883
Abstract: Provided are a transgenic animal model, a method for constructing same, and use thereof. An Axin1flox/flox transgenic mouse is used to mate with an Agc1-CreER transgenic mouse to produce an Axin1+Agc1ER condition knockout mouse. Then by means of tamoxifen induction, the Axin1 expression in the Axin1+Agc1ER condition knockout mouse is down-regulated, and a disease combined model with the pathological characteristics of “growth plate chondrocyte hypertrophy, heterotopic ossification and articular cartilage degeneration of knee joints” is successfully established. The model is similar to clinically related pathological features, and can be used for systematically studying the pathogenesis of growth plate chondrocyte hypertrophy, heterotopic ossification and osteoarthritis and further screening for drugs for treating related diseases.
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