-
公开(公告)号：WO2016100701A1
公开(公告)日：2016-06-23
申请号：PCT/US2015/066440
申请日：2015-12-17
Applicant: SINGULEX, INC.
Inventor： LIVINGSTON, Richard , GILBERT, Michelle , FELBERG, Jacqueline , BISHOP, Jeffrey
CPC classification number: G01N21/6428 , G01J3/4406 , G01N21/645 , G01N21/6452 , G01N33/5302 , G01N33/536 , G01N33/58 , G01N33/6845 , G01N2021/6419 , G01N2021/6421 , G01N2021/6441 , G01N2201/0612 , G01N2201/103 , G01N2201/104 , G01N2201/105
Abstract: Analyzers and analyzer systems that include an analyzer for determining multiple label species, methods of using the analyzer and analyzer systems to analyze samples, are disclosed herein. The analyzer includes one or more sources of electromagnetic radiation to provide electromagnetic radiation at wavelengths within the excitation bands of one or more fluorophore species to an interrogation space that is translated through the sample to detect the presence or absence of molecules of different target analytes. The analyzer may also include one or more detectors configured to detect electromagnetic radiation emitted from the one or more fluorophore species. The analyzer for determining multiple target molecule species provided herein is useful for diagnostics because the concentration of multiple species of target molecules may be determined in a single sample and with a single system.
Abstract translation: 本文公开了包括用于确定多个标签种类的分析器，使用分析仪和分析仪系统分析样品的方法的分析仪和分析仪系统。 分析仪包括一个或多个电磁辐射源，以将一个或多个荧光团物质的激发带内的波长处的电磁辐射提供给通过样品翻译的询问空间，以检测不同目标分析物的分子的存在或不存在。 分析器还可以包括被配置为检测从一个或多个荧光团物种发射的电磁辐射的一个或多个检测器。 用于确定本文提供的多种靶分子物质的分析仪可用于诊断，因为可以在单个样品中和单个系统中确定多种目标分子的浓度。
-
公开(公告)号：WO2010144358A1
公开(公告)日：2010-12-16
申请号：PCT/US2010/037613
申请日：2010-06-07
Applicant: SINGULEX, INC. , GOIX, Philippe, J. , PUSKAS, Robert , TODD, John , LIVINGSTON, Richard , HELD, Douglas , AGEE, Sara
Inventor： GOIX, Philippe, J. , PUSKAS, Robert , TODD, John , LIVINGSTON, Richard , HELD, Douglas , AGEE, Sara
CPC classification number: G01N33/6869 , G01N33/6893 , G01N2333/32 , G01N2333/47 , G01N2333/4712 , G01N2333/525 , G01N2333/54 , G01N2333/5412 , G01N2333/58 , G01N2800/32 , G01N2800/325 , G01N2800/60
Abstract: Cardiovascular disease, e.g., congestive heart failure, is often first diagnosed after the onset of clinical symptoms, eliminating potential for early intervention. The invention provides a multi-marker immunoassay, including cardiac pathology and vascular inflammation biomarkers, yielding a more sensitive assay for early detection of CHF in plasma. A panel consisting of cardiac pathology (cTnl, BNP) and vascular inflammation (IL-6, TNFα, IL- 17a) biomarkers provided a sensitivity of 94% for association with CHF.
Abstract translation: 心血管疾病，例如充血性心力衰竭，经常在临床症状发作后首先诊断，消除早期干预的可能性。 本发明提供了多标志物免疫测定，包括心脏病理学和血管炎症生物标志物，产生用于血浆中CHF早期检测的更敏感的测定。 由心脏病理学（cTnl，BNP）和血管炎症（IL-6，TNFa，IL-17a）生物标记组成的小组提供了与CHF相关的94％的灵敏度。
-
3.发明申请
公开(公告)号：WO2008048371A3
公开(公告)日：2008-04-24
申请号：PCT/US2007/008394
申请日：2007-04-04
Applicant: SINGULEX, INC. , GOIX, Philippe , PUSKAS, Robert , TODD, John , LIVINGSTON, Richard , HELD, Douglas
Inventor： GOIX, Philippe , PUSKAS, Robert , TODD, John , LIVINGSTON, Richard , HELD, Douglas
Abstract: Disclosed are methods, kits, and compositions for fluorescent detection of single biomolecules, e.g. proteins, using highly sensitive fluorescent dyes and a flow cell with one interrogation space for irradiation by focused laser beam. The methods, kits, and compositions are useful in determining concentrations of molecules in samples to levels of 1 femtomolar, 1 attomolar, or lower. The methods, kits, and compositions also allow the determination of concentration over a wide range, e.g., 7-log range, without need for sample dilution.
-
公开(公告)号：WO2017205868A1
公开(公告)日：2017-11-30
申请号：PCT/US2017/034988
申请日：2017-05-30
Applicant: SINGULEX, INC.
Inventor： LIVINGSTON, Richard , ONORATO, Robert , WANG, Danni , GILBERT, Michele
Abstract: A detector captures an image in response to one or more optical elements directing a first electromagnetic radiation to a binding surface. The image is defined by a plurality of pixels. Each pixel provides a signal. The signals provided by a subset of the pixels results at least in part from a second electromagnetic radiation emitted by target molecules bound to the binding surface, in response to the first electromagnetic radiation. The subset of pixels indicates a presence of the target molecules in corresponding areas of the binding surface. A processor determines a noise signal threshold based on an average background noise signal for the plurality of pixels. The processor identifies the subset of pixels indicating the presence of the target molecules by identifying the pixels having a signal greater than the noise signal threshold. The processor determines a count of the target molecules based on the subset of pixels.
Abstract translation: 响应于一个或多个光学元件将第一电磁辐射引导至结合表面，检测器捕获图像。 图像由多个像素定义。 每个像素提供一个信号。 响应于第一电磁辐射，由像素子集提供的信号至少部分地由结合到结合表面的目标分子发射的第二电磁辐射产生。 像素子集指示结合表面的相应区域中存在目标分子。 处理器基于多个像素的平均背景噪声信号来确定噪声信号阈值。 处理器通过识别具有大于噪声信号阈值的信号的像素来识别指示存在目标分子的像素的子集。 处理器根据像素子集确定目标分子的计数。
-
公开(公告)号：WO2017048815A1
公开(公告)日：2017-03-23
申请号：PCT/US2016/051692
申请日：2016-09-14
Applicant: SINGULEX, INC.
Inventor： BISHOP, Jeffrey , LIVINGSTON, Richard , FELBERG, Jacqueline , KYGER, Erich
IPC: B01L3/00
CPC classification number: B01L3/502715 , B01L2300/0681 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2400/0481
Abstract: The disclosure is directed to a system including a microfluidic cartridge having a fluidic pathway and onboard reagents for processing a sample for analysis. The system includes an an optics module including an electromagnetic radiation source, an objective, and a detector, and a translating that translates at least one of the cartridge or the optics module so as to scan a processing sample with focused electromagnetic radiation. Analysis methods using the system are disclosed.
Abstract translation: 本公开涉及包括具有流体路径的微流体盒和用于处理用于分析的样品的载体试剂的系统。 该系统包括包括电磁辐射源，物镜和检测器的光学模块以及平移至少一个盒或光学模块以便用聚焦电磁辐射扫描处理样品的平移装置。 公开了使用该系统的分析方法。
-
Patent Agency Ranking
公开(公告)号：WO2007114947A3
公开(公告)日：2007-10-11
申请号：PCT/US2007/008506
申请日：2007-04-04
Applicant: SINGULEX, INC. , GOIX, Philippe , PUSKAS, Robert , TODD, John , LIVINGSTON, Richard , HELD, Douglas
Inventor： GOIX, Philippe , PUSKAS, Robert , TODD, John , LIVINGSTON, Richard , HELD, Douglas
IPC: G01N33/53
Abstract: The invention provides methods, compositions, kits, and systems for the sensitive detection of cardiac troponin, Such methods, compositions, kits, and systems are useful in diagnosis, prognosis, and determination of methods of treatment in conditions that involve release of cardiac troponin.
-
公开(公告)号：EP3256856A1
公开(公告)日：2017-12-20
申请号：EP15871090.5
申请日：2015-12-17
Applicant: Singulex, Inc.
Inventor： LIVINGSTON, Richard , GILBERT, Michelle , FELBERG, Jacqueline , BISHOP, Jeffrey
CPC classification number: G01N21/6428 , G01J3/4406 , G01N21/645 , G01N21/6452 , G01N33/5302 , G01N33/536 , G01N33/58 , G01N33/6845 , G01N2021/6419 , G01N2021/6421 , G01N2021/6441 , G01N2201/0612 , G01N2201/103 , G01N2201/104 , G01N2201/105
Abstract: Analyzers and analyzer systems that include an analyzer for determining multiple label species, methods of using the analyzer and analyzer systems to analyze samples, are disclosed herein. The analyzer includes one or more sources of electromagnetic radiation to provide electromagnetic radiation at wavelengths within the excitation bands of one or more fluorophore species to an interrogation space that is translated through the sample to detect the presence or absence of molecules of different target analytes. The analyzer may also include one or more detectors configured to detect electromagnetic radiation emitted from the one or more fluorophore species. The analyzer for determining multiple target molecule species provided herein is useful for diagnostics because the concentration of multiple species of target molecules may be determined in a single sample and with a single system.
-
8.发明公开METHODS AND COMPOSITIONS FOR HIGHLY SENSITIVE ANALYSIS OF MARKERS AND DETECTION OF MOLECULES 审中-公开方法和组合物用于分子的检测高敏感性分析和标记
公开(公告)号：EP2016394A2
公开(公告)日：2009-01-21
申请号：EP07861282.7
申请日：2007-04-04
Applicant: Singulex, Inc.
Inventor： GOIX, Philippe , PUSKAS, Robert , TODD, John , LIVINGSTON, Richard , HELD, Douglas
CPC classification number: G01N33/6887 , G01N15/06 , G01N15/1459 , G01N21/6428 , G01N33/577 , G01N33/582 , G01N2015/0693 , G01N2015/1006 , G01N2015/1486 , G01N2201/1247 , G01N2201/12761 , G01N2800/32 , G01N2800/324 , G01N2800/52 , Y10T436/105831
Abstract: The invention provides methods, compositions, kits, and systems for the sensitive detection of cardiac troponin. Such methods, compositions, kits, and systems are useful in diagnosis, prognosis, and determination of methods of treatment in conditions that involve release of cardiac troponin.
Abstract translation: 本发明提供了方法，组合物，试剂盒和系统，用于心脏肌钙蛋白的灵敏的检测。 搜索方法，组合物，试剂盒和系统诊断，预后有重要意义，并在条件治疗方法的决心做了包括心肌肌钙蛋白的释放。
-
公开(公告)号：EP3349899A1
公开(公告)日：2018-07-25
申请号：EP16847215.7
申请日：2016-09-14
Applicant: Singulex, Inc.
Inventor： BISHOP, Jeffrey , LIVINGSTON, Richard , FELBERG, Jacqueline , KYGER, Erich
IPC: B01L3/00
CPC classification number: B01L3/502715 , B01L2200/10 , B01L2300/0681 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2400/0481 , G01N21/31 , G01N21/6428 , G01N2021/6439
Abstract: The disclosure is directed to a system including a microfluidic cartridge having a fluidic pathway and onboard reagents for processing a sample for analysis. The system includes an optics module including an electromagnetic radiation source, an objective, and a detector, and a translating that translates at least one of the cartridge or the optics module so as to scan a processing sample with focused electromagnetic radiation. Analysis methods using the system are disclosed.
-
公开(公告)号：EP2002260B1
公开(公告)日：2015-11-04
申请号：EP07754941.8
申请日：2007-04-04
Inventor： GOIX, Philippe , PUSKAS, Robert , TODD, John , LIVINGSTON, Richard , HELD, Douglas , WU, Alan H.
IPC: G01N33/53
CPC classification number: G01N33/6887 , G01N15/06 , G01N15/1459 , G01N21/6428 , G01N33/577 , G01N33/582 , G01N2015/0693 , G01N2015/1006 , G01N2015/1486 , G01N2201/1247 , G01N2201/12761 , G01N2800/32 , G01N2800/324 , G01N2800/52 , Y10T436/105831
Abstract: The invention provides methods, compositions, kits, and systems for the sensitive detection of cardiac troponin. Such methods, compositions, kits, and systems are useful in diagnosis, prognosis, and determination of methods of treatment in conditions that involve release of cardiac troponin.
-
-
-
-
-
-
-
-
-
Search Results
13
records
(took 0.018 seconds)
