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公开(公告)号：AU2010259022A1
公开(公告)日：2011-12-01
申请号：AU2010259022
申请日：2010-06-07
Applicant: SINGULEX INC
Inventor： GOIX PHILIPPE J , ROBERT PUSKAS , JOHN TODD , RICHARD LIVINGSTON , DOUGLAS HELD , SARA LE
Abstract: Cardiovascular disease, e.g., congestive heart failure, is often first diagnosed after the onset of clinical symptoms, eliminating potential for early intervention. The invention provides a multi-marker immunoassay, including cardiac pathology and vascular inflammation biomarkers, yielding a more sensitive assay for early detection of CHF in plasma. A panel consisting of cardiac pathology (cTnl, BNP) and vascular inflammation (IL-6, TNFα, IL- 17a) biomarkers provided a sensitivity of 94% for association with CHF.
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