公开(公告)号：ZA200706258B

公开(公告)日：2009-08-26

申请号：ZA200706258

申请日：2007-07-27

Applicant: SOLVAY PHARM BV

Inventor： BENJAMIN DRUKARCH ,  FEENSTRA ROELOF W ,  JEAN-LOUISE BURGOT ,  IWEMA BAKKER WOUTER I ,  TULP MARTINUS TH M ,  SCHOFFELMEER ANTON N M ,  MARIE-ODILE CHRISTEN ,  MARYLENE CHOLLET ,  VAN VLIET BERNARD J

IPC: A61K20090101 ,  C07D20090101

Abstract: The present disclosure relates to dithiolethione derivatives as monoamino oxidase inhibitors, in particular MAO-B inhibitors, to methods for the preparation of these compounds and to novel intermediates useful for the synthesis of said dithiolethiones derivatives. The present disclosure also relates to the use of a compound disclosed herein for the manufacture of a medicament giving a beneficial effect. In embodiments of the present disclosure specific compounds disclosed herein are used for the manufacture of a medicament useful in the treatment, amelioration or prevention of conditions associated with dysfunction of monoamine neurotransmission. The compounds have the general formula (1) wherein the symbols have the meanings given in the specification.