公开(公告)号：WO03068207A2

公开(公告)日：2003-08-21

申请号：PCT/EP0350015

申请日：2003-02-11

Applicant: SOLVAY PHARM BV ,  BRONZOVA JULIANA B ,  FEENSTRA ROELOF W ,  GLENNON JEFFREY C ,  MCCREARY ANDREW C ,  VAN RANDEN JAN ,  RONKEN ERIC ,  VAN SCHARRENBURG GUSTAAF J M

Inventor： BRONZOVA JULIANA B ,  FEENSTRA ROELOF W ,  GLENNON JEFFREY C ,  MCCREARY ANDREW C ,  VAN RANDEN JAN ,  RONKEN ERIC ,  VAN SCHARRENBURG GUSTAAF J M

IPC: A61K45/00 ,  A61K31/00 ,  A61K31/138 ,  A61K31/445 ,  A61K31/48 ,  A61K31/495 ,  A61K31/535 ,  A61K31/55 ,  A61K45/06 ,  A61P25/00 ,  A61P25/14 ,  A61P25/18 ,  A61P25/22 ,  A61P25/24 ,  A61P43/00

CPC classification number: A61K31/55 ,  A61K31/00 ,  A61K31/138 ,  A61K31/445 ,  A61K31/48 ,  A61K31/495 ,  A61K31/535

Abstract: The invention relates to the use of a compound or a combination of compounds having partial dopamine-D2 receptor agonistic activity and serotonin and/or noradrenaline reuptake inhibitory activity, for the preparation of a pharmaceutical composition for the treatment of psychiatric and/or neurologic disorders caused by disturbances of the major monoaminergic dopamine, serotonin and/or nordrenaline systems or that can be treated via manipulation of those systems.

Abstract translation: 本发明涉及使用具有部分多巴胺-D2受体激动活性的化合物或组合，以及5-羟色胺和/或去甲肾上腺素再摄取抑制活性，用于制备用于治疗引起的精神病和/或神经障碍的药物组合物 主要的单胺能多巴胺，5-羟色胺和/或肾上腺素系统的紊乱或可以通过操纵这些系统来治疗。

公开(公告)号：PT1395583E

公开(公告)日：2005-06-30

申请号：PT02722107

申请日：2002-02-19

Applicant: SOLVAY PHARM BV

Inventor： RONKEN ERIC ,  SCHARRENBURG GUSTAAF J M VAN ,  MCCREARY ANDREW C ,  FEENSTRA ROELOF W ,  KRUSE CORNELIS G

IPC: A61K31/496 ,  A61P25/00 ,  A61P25/16 ,  A61P25/22 ,  A61P25/24 ,  A61P43/00 ,  C07D413/12 ,  C07D471/06

Abstract: The invention relates to novel phenylpiperazine derivatives of the formula wherein: -R represents the group (a) or (b) as indicated in the description. These compounds are (partial) D2 receptor agonists and are usefull for treating CNS disorders, in particular Parkinson's disease.

公开(公告)号：PL370632A1

公开(公告)日：2005-05-30

申请号：PL37063203

申请日：2003-02-11

Applicant: SOLVAY PHARM BV

Inventor： BRONZOVA JULIANA B ,  FEENSTRA ROELOF W ,  GLENNON JEFFREY C ,  MCCREARY ANDREW C ,  VAN RANDEN JAN ,  RONKEN ERIC ,  VAN SCHARRENBURG GUSTAAF

IPC: A61K45/00 ,  A61K31/00 ,  A61K31/138 ,  A61K31/445 ,  A61K31/48 ,  A61K31/495 ,  A61K31/535 ,  A61K31/55 ,  A61K45/06 ,  A61P25/00 ,  A61P25/14 ,  A61P25/18 ,  A61P25/22 ,  A61P25/24 ,  A61P43/00

Abstract: The invention relates to the use of a compound or a combination of compounds having partial dopamine-D2 receptor agonistic activity and serotonin and/or noradrenaline reuptake inhibitory activity, for the preparation of a pharmaceutical composition for the treatment of psychiatric and/or neurologic disorders caused by disturbances of the major monoaminergic (dopamine, serotonin and/or nordrenaline) systems or that can be treated via manipulation of those systems.

公开(公告)号：HRP20040276A2

公开(公告)日：2005-04-30

申请号：HRP20040276

申请日：2004-03-19

Applicant: SOLVAY PHARM BV

Inventor： BRONZOVA JULIANA B ,  FEENSTRA ROELOF W ,  GLENNON JEFFREY C ,  MCCREARY ANDREW C ,  RANDEN JAN VAN ,  RONKEN ERIC ,  SCHARRENBURG GUUSTAAF J M VAN

IPC: A61K45/00 ,  A61K31/00 ,  A61K31/138 ,  A61K31/445 ,  A61K31/48 ,  A61K31/495 ,  A61K31/535 ,  A61K31/55 ,  A61K45/06 ,  A61P25/00 ,  A61P25/14 ,  A61P25/18 ,  A61P25/22 ,  A61P25/24 ,  A61P43/00

Abstract: The invention relates to the use of a compound or a combination of compounds having partial dopamine-D2 receptor agonistic activity and serotonin and/or noradrenaline reuptake inhibitory activity, for the preparation of a pharmaceutical composition for the treatment of psychiatric and/or neurologic disorders caused by disturbances of the major monoaminergic (dopamine, serotonin and/or nordrenaline) systems or that can be treated via manipulation of those systems.

公开(公告)号：NZ523135A

公开(公告)日：2005-02-25

申请号：NZ52313502

申请日：2002-02-19

Applicant: SOLVAY PHARM BV

Inventor： FEENSTRA ROELOF W ,  RONKEN ERIC ,  KRUSE CORNELIS G ,  MCCREARY ANDREW C ,  VAN SCHARRENBURG GUSTAAF J M

IPC: A61K31/496 ,  A61P25/00 ,  A61P25/16 ,  A61P25/22 ,  A61P25/24 ,  A61P43/00 ,  C07D413/12 ,  C07D471/06

Abstract: Phenylpiperazine derivatives of the formula (I) and their salts that show high affinity for both the dopamine D2 receptor and the serotonin reuptake site, that are active in therapeutic models sensitive to clinically relevant antipsychotics and that can be used for the treatment of affections or diseases of the central nervous system caused by disturbances in either the dopaminergic or serotonergic systems, for example: aggression, anxiety disorders, autism, vertigo, depression, disturbances of cognition or memory, Parkinson's disease and in schizophrenia and other psychotic disorders are disclosed, wherein: R is a group of the formula (a) or (b).

公开(公告)号：ZA200209897B

公开(公告)日：2004-03-05

申请号：ZA200209897

申请日：2002-12-05

Applicant: SOLVAY PHARM BV

Inventor： FEENSTRA ROELOF W ,  KRUSE CORNELIS G ,  SCHARRENBURG GUSTAAF J M VAN ,  RONKEN ERIC ,  MCCREARY ANDREW C

IPC: A61K31/496 ,  A61P25/00 ,  A61P25/16 ,  A61P25/22 ,  A61P25/24 ,  A61P43/00 ,  C07D413/12 ,  C07D471/06 ,  C07D

Abstract: The invention relates to novel phenylpiperazine derivatives of the formula wherein: -R represents the group (a) or (b) as indicated in the description. These compounds are (partial) D2 receptor agonists and are usefull for treating CNS disorders, in particular Parkinson's disease.

公开(公告)号：HU0303329A2

公开(公告)日：2004-01-28

申请号：HU0303329

申请日：2002-02-19

Applicant: SOLVAY PHARM BV

Inventor： FEENSTRA ROELOF W ,  KRUSE CORNELIS G ,  MCCREARY ANDREW C ,  RONKEN ERIC ,  VAN SCHARRENBURG GUSTAAF J M

IPC: A61K31/496 ,  A61P25/00 ,  A61P25/16 ,  A61P25/22 ,  A61P25/24 ,  A61P43/00 ,  C07D413/12 ,  C07D471/06

Abstract: The invention relates to novel phenylpiperazine derivatives of the formula wherein: -R represents the group (a) or (b) as indicated in the description. These compounds are (partial) D2 receptor agonists and are usefull for treating CNS disorders, in particular Parkinson's disease.

公开(公告)号：CA2411973A1

公开(公告)日：2002-08-29

申请号：CA2411973

申请日：2002-02-19

Applicant: SOLVAY PHARM BV

Inventor： VAN SCHARRENBURG GUSTAAF J M ,  FEENSTRA ROELOF W ,  RONKEN ERIC ,  KRUSE CORNELIS G ,  MCCREARY ANDREW C

IPC: A61K31/496 ,  A61P25/00 ,  A61P25/16 ,  A61P25/22 ,  A61P25/24 ,  A61P43/00 ,  C07D413/12 ,  C07D471/06 ,  C07D413/10 ,  A61P25/18 ,  A61P25/28

Abstract: The invention relates to novel phenylpiperazine derivatives of the formulawherein:- R represents the group (a) or (b) as indicated in the description. These compounds are (partial) D2 receptor agonists and are usefull for treating CNS disorders, in particular Parkinson's disease.

公开(公告)号：DE60203042T2

公开(公告)日：2006-01-19

申请号：DE60203042

申请日：2002-02-19

Applicant: SOLVAY PHARM BV

Inventor： FEENSTRA ROELOF W ,  RONKEN ERIC ,  KRUSE CORNELIS G ,  MCCREARY ANDREW C ,  VAN SCHARRENBURG GUSTAAF J M

IPC: A61K31/496 ,  A61P25/00 ,  A61P25/16 ,  A61P25/22 ,  A61P25/24 ,  A61P43/00 ,  C07D413/12 ,  C07D471/06

Abstract: The invention relates to novel phenylpiperazine derivatives of the formula wherein: -R represents the group (a) or (b) as indicated in the description. These compounds are (partial) D2 receptor agonists and are usefull for treating CNS disorders, in particular Parkinson's disease.

公开(公告)号：ES2235029T3

公开(公告)日：2005-07-01

申请号：ES02722107

申请日：2002-02-19

Applicant: SOLVAY PHARM BV

Inventor： FEENSTRA ROELOF W ,  RONKEN ERIC ,  KRUSE CORNELIS G ,  MCCREARY ANDREW C ,  VAN SCHARRENBURG GUSTAAF J M

IPC: A61K31/496 ,  A61P25/00 ,  A61P25/16 ,  A61P25/22 ,  A61P25/24 ,  A61P43/00 ,  C07D413/12 ,  C07D471/06

Abstract: Derivados de fenilpiperazina que tienen la fórmula (1) **(Fórmula)** en la que R es un grupo de la fórmula (a) o (b) **(Fórmula)** y sus sales.