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公开(公告)号：ES2317335T3
公开(公告)日：2009-04-16
申请号：ES05816322
申请日：2005-12-06
Applicant: SOLVAY PHARM BV
Inventor： FEENSTRA ROELOF W , STOIT AXEL , TERPSTRA JAN-WILLEM , PRAS-RAVES MARIA L , MCCREARY ANDREW C , VAN VLIET BERNARD J
IPC: A61K31/423 , A61P25/00 , C07D263/58
Abstract: Compuestos de fórmula general (1): ** ver fórmula** en donde X= Su O, R1 es H, alquilo(C1-C6), CF3, CH2CF3, OH u O-alquilo(C1-C6), R 2 es H, alquilo(C 1-C 6), halógeno o ciano, R3 es H ó alquilo(C1-C6), R 4 es H, alquilo(C 1-C 6), opcionalmente sustituido con un átomo de halógeno, en donde: ** ver fórmula** se selecciona del grupo que consiste en:** ver fórmula** y los tautómeros, estereoisómeros y N-óxidos de los mismos, así como las sales, hidratos y solvatos farmacológicamente aceptables de dichos compuestos de fórmula (1) y sus tautómeros, estereoisómeros y N-óxidos.
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公开(公告)号：DK1827427T3
公开(公告)日：2008-11-24
申请号：DK05850037
申请日：2005-12-06
Applicant: SOLVAY PHARM BV
Inventor： FEENSTRA ROELOF W , STOIT AXEL , TERPSTRA JAN-WILLEM , PRAS-RAVES MARIA L , MCCREARY ANDREW C , VAN VLIET BERNARD J , HESSELINK MAYKE B , KRUSE CORNELIS G , VAN SCHARRENBURG GUSTAAF J M
IPC: A61K31/423 , A61P25/00 , C07D263/58 , C07D413/12
Abstract: The invention relates to a group of novel phenylpiperazine derivatives with a dual mode of action: serotonin reuptake inhibition and partial agonism on dopamine -D2 receptors. The invention also relates to the use of a compound disclosed herein for the manufacture of a medicament giving a beneficial effect. The compounds have the general formula (1) wherein the symbols have the meanings given in the specification.
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公开(公告)号：NO20072981L
公开(公告)日：2007-09-05
申请号：NO20072981
申请日：2007-06-11
Applicant: SOLVAY PHARM BV
Inventor： SCHARRENBURG GUSTAAF JOHAN MAR , FEENSTRA ROELOF W , KRUSE CORNELIS GERRIT , MCCREARY ANDREW C , PRAS-RAVES MARIA L , HESSELINK MAYKE B , TERPSTRA JAN-WILLEM , STOIT AXEL , VLIET BERNARD J VAN
IPC: C07D263/58 , A61K31/423 , A61P25/00 , C07D413/12
Abstract: The invention relates to a group of novel phenylpiperazine derivatives with a dual mode of action: serotonin reuptake inhibition and partial agonism on dopamine -D2 receptors. The invention also relates to the use of a compound disclosed herein for the manufacture of a medicament giving a beneficial effect. The compounds have the general formula (1) wherein the symbols have the meanings given in the specification.
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公开(公告)号：NO20072977A
公开(公告)日：2007-09-05
申请号：NO20072977
申请日：2007-06-11
Applicant: SOLVAY PHARM BV
Inventor： SCHARRENBURG GUSTAAF JOHAN MAR , FEENSTRA ROELOF W , KRUSE CORNELIS GERRIT , MCCREARY ANDREW C , PRAS-RAVES MARIA L , HESSELINK MAYKE B , TERPSTRA JAN-WILLEM , STOIT AXEL , VLIET BERNARD J VAN
IPC: C07D263/58 , A61K31/423 , A61P25/00 , C07D413/12
CPC classification number: C07D263/58 , C07D413/12
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公开(公告)号：NO20072969L
公开(公告)日：2007-08-31
申请号：NO20072969
申请日：2007-06-11
Applicant: SOLVAY PHARM BV
Inventor： SCHARRENBURG GUSTAAF JOHAN MAR , FEENSTRA ROELOF W , KRUSE CORNELIS GERRIT , MCCREARY ANDREW C , PRAS-RAVES MARIA L , HESSELINK MAYKE B , TERPSTRA JAN-WILLEM , STOIT AXEL , VLIET BERNARD J VAN
IPC: C07D263/58
Abstract: The invention relates to a group of novel phenylpiperazine derivatives with a dual mode of action: serotonin reuptake inhibition and partial agonism on dopamine -D2 receptors. The invention also relates to the use of a compound disclosed herein for the manufacture of a medicament giving a beneficial effect. The compounds have the general formula (1) wherein the symbols have the meanings given in the specification.
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Patent Agency Ranking
公开(公告)号：NO20072974A
公开(公告)日：2007-08-23
申请号：NO20072974
申请日：2007-06-11
Applicant: SOLVAY PHARM BV
Inventor： SCHARRENBURG GUSTAAF J M VAN , FEENSTRA ROELOF W , MCCREARY ANDREW C , PRAS-RAVES MARIA L , HESSELINK MAYKE B , TERPSTRA JAN-WILLEM , STOIT AXEL , VLIET BERNARD J VAN , KRUSE CORNELIS G
IPC: C07D413/12
CPC classification number: C07D263/58 , C07D413/12
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公开(公告)号：CA2587357A1
公开(公告)日：2006-06-15
申请号：CA2587357
申请日：2005-12-06
Applicant: SOLVAY PHARM BV
Inventor： FEENSTRA ROELOF W , KRUSE CORNELIS G , STOIT AXEL , TERPSTRA JAN-WILLEM , VAN VLIET BERNARD J , HESSELINK MAYKE B , PRAS-RAVES MARIA L , MCCREARY ANDREW C , VAN SCHARRENBURG GUSTAAF J M
IPC: A61K31/423 , A61P25/00 , C07D263/58
Abstract: The invention relates to a group of novel phenylpiperazine derivatives with a dual mode of action: serotonin reuptake inhibition and partial agonism on dopamine -D2 receptors. The invention also relates to the use of a compound disclosed herein for the manufacture of a medicament giving a beneficial effect. The compounds have the general formula (1) wherein the symbols have the meanings given in the specification.
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公开(公告)号：DK1824479T3
公开(公告)日：2009-03-09
申请号：DK05816322
申请日：2005-12-06
Applicant: SOLVAY PHARM BV
Inventor： FEENSTRA ROELOF W , STOIT AXEL , TERPSTRA JAN-WILLEM , PRAS-RAVES MARIA L , MCCREARY ANDREW C , VAN VLIET BERNARD J , HESSELINK MAYKE B , KRUSE CORNELIS G , VAN SCHARRENBURG G J M
IPC: A61K31/423 , A61P25/00 , C07D263/58
Abstract: The invention relates to a group of novel phenylpiperazine derivatives with a dual mode of action: serotonin reuptake inhibition and partial agonism on dopamine -D2 receptors. The invention also relates to the use of a compound disclosed herein for the manufacture of a medicament giving a beneficial effect. The compounds have the general formula (1) wherein the symbols have the meanings given in the specification.
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公开(公告)号：NO20072977L
公开(公告)日：2007-09-05
申请号：NO20072977
申请日：2007-06-11
Applicant: SOLVAY PHARM BV
Inventor： SCHARRENBURG GUSTAAF JOHAN MAR , FEENSTRA ROELOF W , KRUSE CORNELIS GERRIT , MCCREARY ANDREW C , PRAS-RAVES MARIA L , HESSELINK MAYKE B , TERPSTRA JAN-WILLEM , STOIT AXEL , VLIET BERNARD J VAN
IPC: C07D263/58 , A61K31/423 , A61P25/00 , C07D413/12
Abstract: The invention relates to a group of novel phenylpiperazine derivatives with a dual mode of action: serotonin reuptake inhibition and partial agonism on dopamine -D2 receptors. The invention also relates to the use of a compound disclosed herein for the manufacture of a medicament giving a beneficial effect. The compounds have the general formula (1) wherein the symbols have the meanings given in the specification.
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公开(公告)号：NO20072969A
公开(公告)日：2007-08-31
申请号：NO20072969
申请日：2007-06-11
Applicant: SOLVAY PHARM BV
Inventor： SCHARRENBURG GUSTAAF JOHAN MAR , FEENSTRA ROELOF W , KRUSE CORNELIS GERRIT , MCCREARY ANDREW C , PRAS-RAVES MARIA L , HESSELINK MAYKE B , TERPSTRA JAN-WILLEM , STOIT AXEL , VLIET BERNARD J VAN
IPC: C07D263/58
CPC classification number: C07D263/58 , C07D413/12
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