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    2.
    发明专利
    未知

    公开(公告)号：DE602006004363D1

    公开(公告)日：2009-01-29

    申请号：DE602006004363

    申请日：2006-08-21

    Applicant: SOLVAY PHARM BV

    Inventor： KOOPMAN THEODORUS S ,  KOSTER HENDRIK J ,  VAN AMSTERDAM PETER H ,  FEENSTRA ROELOF W ,  VERHAGE MARINUS ,  MCCREARY ANDREW C ,  HESSELINK MAYKE B ,  VAN SCHARRENBURG GUSTAAF J

    IPC: C07D263/58 ,  A61K31/423 ,  A61P25/00 ,  C07D295/24

    Abstract: The present invention relates to N-oxides of certain piperazine and piperidine derivatives and to methods for the preparation of these compounds. The invention also relates to the use of compounds disclosed herein for the manufacture of a medicament giving a beneficial effect. A beneficial effect is disclosed herein or apparent to a person skilled in the art from the specification and general knowledge in the art. The invention also relates to the use of a compound of the invention for the manufacture of a medicament for treating or preventing a disease or condition. More particularly, the invention relates to a new use for the treatment of a disease or condition disclosed herein or apparent to a person skilled in the art from the specification and general knowledge in the art. In embodiments of the invention specific compounds disclosed herein are used for the manufacture of a medicament useful in the treatment of CNS-disorders, in particular the treatment of anxiety disorders, including generalized anxiety disorder and panic disorder, obsessive compulsive disorder, aggression, addiction (including craving), depression, autism, vertigo, schizophrenia and other psychotic disorders, Parkinson's disease and disturbances of cognition and memory. The compounds have the general formula (1) wherein the symbols have the meanings given in the specification.

    N-OXIDES AS PRODRUGS OF PIPERAZINE & PIPERIDINE DERIVATIVES
    5.
    发明专利
    N-OXIDES AS PRODRUGS OF PIPERAZINE & PIPERIDINE DERIVATIVES 未知

    公开(公告)号：CA2621158A1

    公开(公告)日：2007-03-01

    申请号：CA2621158

    申请日：2006-08-21

    Applicant: SOLVAY PHARM BV

    Inventor： FEENSTRA ROELOF W ,  VAN AMSTERDAM PETER H ,  VERHAGE MARINUS ,  HESSELINK MAYKE B ,  VAN SCHARRENBURG GUSTAAF J M ,  KOSTER HENDRIK J ,  MCCREARY ANDREW C ,  KOOPMAN THEODORUS S M

    IPC: C07D263/58 ,  A61K31/423 ,  A61P25/00 ,  C07D295/24

    Abstract: The present invention relates to N-oxides of certain piperazine and piperidine derivatives and to methods for the preparation of these compounds. The invention also relates to the use of compounds disclosed herein for the manufacture of a medicament giving a beneficial effect. A beneficial effect is disclosed herein or apparent to a person skilled in the art from the specification and general knowledge in the art. The invention also relates to the use of a compound of the invention for the manufacture of a medicament for treating or preventing a disease or condition. More particularly, the invention relates to a new use for the treatment of a disease or condition disclosed herein or apparent to a person skilled in the art from the specification and general knowledge in the art. In embodiments of the invention specific compounds disclosed herein are used for the manufacture of a medicament useful in the treatment of CNS-disorders, in particular the treatment of anxiety disorders, including generalized anxiety disorder and panic disorder, obsessive compulsive disorder, aggression, addiction (including craving), depression, autism, vertigo, schizophrenia and other psychotic disorders, Parkinson's disease and disturbances of cognition and memory. The compounds have the general formula (1) wherein the symbols have the meanings given in the specification.

    N-OXIDES AS PRODRUGS OF PIPERAZINE&PIPERIDINE DERIVATIVES
    7.
    发明专利
    N-OXIDES AS PRODRUGS OF PIPERAZINE&PIPERIDINE DERIVATIVES 未知

    公开(公告)号：HRP20090143T3

    公开(公告)日：2009-04-30

    申请号：HRP20090143

    申请日：2009-03-10

    Applicant: SOLVAY PHARM BV

    Inventor： KOOPMAN THEODORUS S M ,  KOSTER HENDRIK J ,  AMSTERDAM PETER H VAN ,  FEENSTRA ROELOF W ,  VERHAGE MARINUS ,  MCCREARY ANDREW C ,  HESSELINK MAYKE B

    IPC: C07D263/58 ,  A61K31/423 ,  A61P25/00 ,  C07D295/24

    Abstract: The present invention relates to N-oxides of certain piperazine and piperidine derivatives and to methods for the preparation of these compounds. The invention also relates to the use of compounds disclosed herein for the manufacture of a medicament giving a beneficial effect. A beneficial effect is disclosed herein or apparent to a person skilled in the art from the specification and general knowledge in the art. The invention also relates to the use of a compound of the invention for the manufacture of a medicament for treating or preventing a disease or condition. More particularly, the invention relates to a new use for the treatment of a disease or condition disclosed herein or apparent to a person skilled in the art from the specification and general knowledge in the art. In embodiments of the invention specific compounds disclosed herein are used for the manufacture of a medicament useful in the treatment of CNS-disorders, in particular the treatment of anxiety disorders, including generalized anxiety disorder and panic disorder, obsessive compulsive disorder, aggression, addiction (including craving), depression, autism, vertigo, schizophrenia and other psychotic disorders, Parkinson's disease and disturbances of cognition and memory. The compounds have the general formula (1) wherein the symbols have the meanings given in the specification.

    DERIVADOS DE BENZOOXAZOLES, COMPOSICIONES FARMACEUTICAS Y SU USO PARA EL TRATAMIENTO DE DESORDENES DEL SISTEMA NERVIOSO.
    8.
    发明专利
    DERIVADOS DE BENZOOXAZOLES, COMPOSICIONES FARMACEUTICAS Y SU USO PARA EL TRATAMIENTO DE DESORDENES DEL SISTEMA NERVIOSO. 未知

    公开(公告)号：AR058022A1

    公开(公告)日：2008-01-23

    申请号：ARP060103590

    申请日：2006-08-17

    Applicant: SOLVAY PHARM BV

    Inventor： KOSTER HENDRINK J ,  VAN AMSTERDAM PETER H ,  FEENSTRA ROELOF W ,  VERHAGE MARINUS ,  MCCREARY ANDREW C ,  HESSELINK MAYKE B ,  VAN SCHARRENBURG GUSTAAF J M ,  KOOPMAN THEODORUS S M

    IPC: C07D263/58 ,  A61K31/423 ,  A61P25/00

    Abstract: En realizaciones de la misma, compuestos específicos descriptos en la presente son utilizados para la fabricacion de un medicamento util en el tratamiento de desordenes del SNC, en particular el tratamiento de desordenes de ansiedad, incluyendo desorden de ansiedad generalizada y desorden de pánico, desorden obsesivo compulsivo, agresion, adiccion (incluyendo ansia), depresion, autismo, vértigo, esquizofrenia y otros desordenes psicoticos, enfermedad de Parkinson y disturbios del conocimiento y memoria. Métodos para su preparacion y composiciones farmacéuticas que los comprenden. Reivindicacion 1: Derivados de piperazina y piperidina de la formula general (1) en donde R1 es hidrogeno, halogeno alquilo C1-3, CN, CF3, OCF3, SCF3, alcoxi C1-3, amino o mono- o dialquil C1-3 sustituido amino, o hidroxi; ---Z representa =C o -N; R2 es hidrogeno o alquilo C1-3; R3 y R4 independientemente representan H o alquilo C1-3, o R3 y R4 juntos puede formar un puente de 2 o 3 átomos de carbono; Q es metilo, etilo o ciclopropilmetilo los cuales grupos etilo o ciclopropilmetilo están opcionalmente sustituidos con uno o más átomos de fluor, o Q es bencilo o 2-, 3- o 4-piridilmetilo, los cuales grupos están opcionalmente sustituidos con uno o más sustituyentes del grupo halogeno, nitro, ciano, amino, mono- o dialquil C1-3amino, alcoxi C1-3, CF3, OCF3, SCF3, alquilo C1-3, alquil C1-3sulfonilo o hidroxilo, o Q es un grupo de la formula (2) en donde R5 es halogeno, hidroxi, alcoxi C1-3 o alquilo C1-3; y q es 0, 1, 2 o 3; Y es fenilo, furanilo o tienilo, los cuales pueden estar sustituidos con 1-3 sustituyentes del grupo hidroxi, halogeno, alcoxi C1-3, alquilo C1-3, ciano, aminocarbonilo, mono- o dialquil C1- 3aminocarbonilo; y tautomeros, estereoisomeros, sales, hidratos y solvatos de los mismos farmacologicamente aceptables.

    N-oxides as prodrugs of piperazine and piperidine derivatives
    9.
    发明专利
    N-oxides as prodrugs of piperazine and piperidine derivatives 未知

    公开(公告)号：AU2006283882A1

    公开(公告)日：2007-03-01

    申请号：AU2006283882

    申请日：2006-08-21

    Applicant: SOLVAY PHARM BV

    Inventor： FEENSTRA ROELOF W ,  MCCREARY ANDREW C ,  HESSELINK MAYKE B ,  KOOPMAN THEODORUS S M ,  KOSTER HENDRIK J ,  SCHARRENBURG GUSTAAF J M VAN ,  AMSTERDAM PETER H VAN ,  VERHAGE MARINUS

    IPC: C07D263/58 ,  A61K31/423 ,  A61P25/00 ,  C07D295/24

    Abstract: The present invention relates to N-oxides of certain piperazine and piperidine derivatives and to methods for the preparation of these compounds. The invention also relates to the use of compounds disclosed herein for the manufacture of a medicament giving a beneficial effect. A beneficial effect is disclosed herein or apparent to a person skilled in the art from the specification and general knowledge in the art. The invention also relates to the use of a compound of the invention for the manufacture of a medicament for treating or preventing a disease or condition. More particularly, the invention relates to a new use for the treatment of a disease or condition disclosed herein or apparent to a person skilled in the art from the specification and general knowledge in the art. In embodiments of the invention specific compounds disclosed herein are used for the manufacture of a medicament useful in the treatment of CNS-disorders, in particular the treatment of anxiety disorders, including generalized anxiety disorder and panic disorder, obsessive compulsive disorder, aggression, addiction (including craving), depression, autism, vertigo, schizophrenia and other psychotic disorders, Parkinson's disease and disturbances of cognition and memory. The compounds have the general formula (1) wherein the symbols have the meanings given in the specification.

    10.
    发明专利
    未知

    公开(公告)号：DK1919883T3

    公开(公告)日：2009-04-14

    申请号：DK06778284

    申请日：2006-08-21

    Applicant: SOLVAY PHARM BV

    Inventor： KOOPMAN THEODORUS S M ,  KOSTER HENDRIK J ,  VAN AMSTERDAM PETER H ,  FEENSTRA ROELOF W ,  VERHAGE MARINUS ,  MCCREARY ANDREW C ,  HESSELINK MAYKE B ,  VAN SCHARRENBURG GUSTAAF J M

    IPC: C07D263/58 ,  A61K31/423 ,  A61P25/00 ,  C07D295/24

    Abstract: The present invention relates to N-oxides of certain piperazine and piperidine derivatives and to methods for the preparation of these compounds. The invention also relates to the use of compounds disclosed herein for the manufacture of a medicament giving a beneficial effect. A beneficial effect is disclosed herein or apparent to a person skilled in the art from the specification and general knowledge in the art. The invention also relates to the use of a compound of the invention for the manufacture of a medicament for treating or preventing a disease or condition. More particularly, the invention relates to a new use for the treatment of a disease or condition disclosed herein or apparent to a person skilled in the art from the specification and general knowledge in the art. In embodiments of the invention specific compounds disclosed herein are used for the manufacture of a medicament useful in the treatment of CNS-disorders, in particular the treatment of anxiety disorders, including generalized anxiety disorder and panic disorder, obsessive compulsive disorder, aggression, addiction (including craving), depression, autism, vertigo, schizophrenia and other psychotic disorders, Parkinson's disease and disturbances of cognition and memory. The compounds have the general formula (1) wherein the symbols have the meanings given in the specification.

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