公开(公告)号：EP3187875A4

公开(公告)日：2018-03-14

申请号：EP15846989

申请日：2015-08-17

Applicant: SONY CORP

Inventor： MATSUMOTO MASAHIRO

IPC: G01N33/558 ,  G01N21/78 ,  G01N33/543

CPC classification number: G01N33/54306 ,  G01N21/78 ,  G01N33/558

Abstract: Provided is a target substance measurement kit for detecting a target substance sensitively in a convenient manner. Provided is a target substance measurement kit including a capturing unit that captures a target substance contained in a liquid and a flow rate control unit that controls the rate of flow of the liquid in the capturing unit. The flow rate control unit is provided downstream from the capturing unit in the flow direction of the liquid.

公开(公告)号：EP2824172A4

公开(公告)日：2015-11-04

申请号：EP13758540

申请日：2013-01-16

Applicant: SONY CORP

Inventor： MATSUMOTO MASAHIRO ,  SATO MASAKI ,  WATANABE HIDETOSHI

IPC: C12M1/00 ,  C12N15/09 ,  G01N37/00

CPC classification number: B01L3/502707 ,  B01L3/5027 ,  B01L3/5088 ,  C12N15/10 ,  C12Q1/6844

公开(公告)号：IN1481MUN2014A

公开(公告)日：2015-04-17

申请号：IN1481MUN2014

申请日：2014-07-22

Applicant: SONY CORP

Inventor： MATSUMOTO MASAHIRO ,  OHNISHI MICHIHIRO ,  KATO YOSHIAKI ,  WATANABE TOSHIO

IPC: B01L3/00

Abstract: A microchip is provided and configured to contain a sample solution for analysis. The microchip including a channel that is maintained at a pressure level less than atmospheric pressure so as to allow flow of the sample solution thru the channel; and a pressure indication section configured to detect a change in the pressure level. A microchip apparatus and a method of manufacturing a microchip are also provided.

公开(公告)号：EP2857846A4

公开(公告)日：2016-02-24

申请号：EP13794114

申请日：2013-03-13

Applicant: SONY CORP

Inventor： WATANABE HIDETOSHI ,  SEGAWA YUJI ,  KAJIHARA JUNJI ,  KOJIMA KENSUKE ,  WATANABE TOSHIO ,  MATSUMOTO MASAHIRO

IPC: G01N35/08 ,  G01N37/00

CPC classification number: B01L3/5027 ,  B01L3/502707 ,  B01L2200/0642 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0883 ,  B01L2300/0887 ,  B01L2300/123 ,  G01N2035/00158

Abstract: Provided is a microchip which enables to easily confirm, from the outside of the microchip, filling of a solution into an analysis region. The microchip includes: an introduction part for introducing a liquid; an analysis region in which a substance contained in the liquid or a reaction product of the substance is analyzed; an indication region to indicate that the analysis region has completely been filled with the liquid; and a flow channel to connect the introduction part, the analysis region, and the indication region. In the microchip, the flow channel is configured in such a manner that an amount of time it takes for the liquid introduced from the introduction part to reach the indication region is longer than an amount of time it takes for the liquid introduced from the introduction part to fill up the analysis region.

公开(公告)号：IN1628MUN2014A

公开(公告)日：2015-05-15

申请号：IN1628MUN2014

申请日：2014-08-13

Applicant: SONY CORP

Inventor： MATSUMOTO MASAHIRO ,  SATO MASAKI ,  WATANABE HIDETOSHI

IPC: C12M1/00 ,  C12N15/09 ,  G01N37/00

Abstract: Provided is a method for producing a microchip for use in a nucleic acid amplification reaction which enables a simple and highly accurate analysis. Provided is a method for producing a microchip for use in a nucleic acid amplification reaction comprising: a solidification step of drying a reagent solution containing at least a portion of a substance needed for the nucleic acid amplification reaction; and an accommodation step of placing a reagent containing the solidified substance in a well which is a reaction place for the nucleic acid amplification reaction. In the microchip for use in a nucleic acid amplification reaction which is produced by the production method the substance needed for the nucleic acid amplification reaction is accommodated in a solidified state. Therefore it becomes possible to inhibit the occurrence of a non specific amplification in a nucleic acid amplification reaction and therefore it becomes possible to carry out an analysis with high accuracy.

公开(公告)号：JP2012042310A

公开(公告)日：2012-03-01

申请号：JP2010183121

申请日：2010-08-18

Applicant: Sony Corp ,  ソニー株式会社

Inventor： KATSUHARA TOMOKO ,  WATABE HIROKI ,  MATSUMOTO MASAHIRO

IPC: G01N1/10 ,  A61B5/00 ,  G01N30/04 ,  G01N33/48 ,  G01N33/50

CPC classification number: A61B10/0064 ,  A61B5/14517 ,  B01L3/502715 ,  G01N35/00009 ,  G01N2001/383 ,  G01N2030/8813

Abstract: PROBLEM TO BE SOLVED: To provide a simple and less invasive physiologically active substance collecting device capable of constantly collecting the physiologically active substance from a living organism.SOLUTION: A physiologically active substance collecting device comprises: a collecting section 1 which contacts a body surface S of a living organism to collect the physiologically active substance from the body surface S of the living organism; and solvent sending means to send solvent to the collecting section 1. The collecting section 1 has an opening 124 to allow the solvent sent from the solvent sending means and distributed in a channel 121 to contact with the body surface S. The physiologically active substance collecting device can collect the physiologically active substance in the solvent by allowing the solvent to contact with the body surface S at the collecting section 1.

Abstract translation: 要解决的问题：提供能够从生物体中不断收集生理活性物质的简单且较少侵入性的生理活性物质收集装置。 解决方案：一种生理活性物质收集装置，包括：收集部分1，其与生物体的体表S接触，以从生物体的体表S收集生理活性物质; 以及将溶剂输送到收集部分1的溶剂送出装置。收集部分1具有开口124，以允许从溶剂输送装置输送的溶剂并分布在通道121中以与体表S接触。收集的生理活性物质 装置可以通过使溶剂在收集部分1与身体表面S接触而在溶剂中收集生理活性物质。版权所有：（C）2012，JPO＆INPIT

公开(公告)号：JP2010190602A

公开(公告)日：2010-09-02

申请号：JP2009032548

申请日：2009-02-16

Applicant: Sony Corp ,  ソニー株式会社

Inventor： KATSUHARA TOMOKO ,  MATSUMOTO MASAHIRO ,  ISHIHARA KAZUHIKO

IPC: G01N30/88 ,  B01J20/281

CPC classification number: B01J20/286 ,  B01J20/28042 ,  B01J20/28097 ,  B01J20/3204 ,  B01J20/327 ,  B01J20/328 ,  B01J2220/52 ,  B01J2220/54 ,  B01J2220/58 ,  B01J2220/82

Abstract: PROBLEM TO BE SOLVED: To provide a separation column capable of especially holding the analysis target molecule in a biomicromolecule on the column efficiently while preventing the adsorption of protein on the column. SOLUTION: This monolithic silica column for separating the biomicromolecule is characterized in that the surface of a silica skeleton and the surfaces of the micropores formed to the silica skeleton are modified by a polymer, which is obtained by polymerizing a monomer composition containing a phosphorylcholine analogue group-containing monomer represented by formula (1) (wherein R 1 , R 2 and R 3 are the same group or different groups and are a hydrogen atom, a 1-6C alkyl group or a hydroxyalkyl group, R 4 is a 1-6C alkylene group, R 5 is a hydrogen atom or a methyl group and n is an integer of 1-4) and the pore size of the micropores of which the surfaces are modified by the polymer has the size fitted to the molecular size of the biomicromolecule being a separation target. COPYRIGHT: (C)2010,JPO&INPIT

Abstract translation: 要解决的问题：提供一种能够有效地将分析靶分子保持在生物分子上的分离柱，同时防止蛋白质在柱上的吸附。 解决方案：用于分离生物分子的该整体式二氧化硅柱的特征在于，二氧化硅骨架的表面和形成于二氧化硅骨架的微孔的表面被聚合物改性，该聚合物通过聚合含有 由式（1）表示的磷酸胆碱类似物基团的单体（其中R 1，R 2，R 2，R 3和R 3）均为相同的基团或不同的基团 并且是氢原子，1-6C烷基或羟烷基，R SP 4是1-6C亚烷基，R SP 5是氢原子或甲基 基团，n是1-4的整数），表面被聚合物改性的微孔的孔径具有与作为分离对象的生物分子的分子尺寸相适应的尺寸。 版权所有（C）2010，JPO＆INPIT

公开(公告)号：JP2010139239A

公开(公告)日：2010-06-24

申请号：JP2008312821

申请日：2008-12-09

Applicant: Sony Corp ,  ソニー株式会社

Inventor： WATABE HIROKI ,  MATSUMOTO MASAHIRO

IPC: G01N30/88 ,  G01N33/15 ,  G01N33/50

Abstract: PROBLEM TO BE SOLVED: To provide a method for detecting with high sensitivity the binding, between an object material and a target material, without having to label, such as fluorescent labeling and a radiation labeling.
SOLUTION: The method for detecting the binding between the materials is provided and includes: a step S1 for implementing a binding reaction of a predetermined quantity of the target material and the object material having a binding capability to the target material (1); a step S3 for quantifying the target material which does not react (2); and a step S4 for calculating a difference between the initial quantity of the target material and a quantitative value of the target material which does not react (3). In the binding detecting method, that the target material and the object material are bound is detected, if the difference is larger than 0.
COPYRIGHT: (C)2010,JPO&INPIT

Abstract translation: 要解决的问题：提供一种高灵敏度地检测物体材料和目标材料之间的结合的方法，而不必标记诸如荧光标记和辐射标记。 提供了用于检测材料之间的结合的方法，包括：用于实现预定量的目标材料与具有与目标材料（1）的结合能力的目标材料的结合反应的步骤S1， ; 用于量化不反应的目标材料的步骤S3（2）; 以及用于计算目标材料的初始量与不反应的目标材料的定量值之间的差的步骤S4（3）。 在结合检测方法中，如果差异大于0，则检测目标材料和物体材料是否结合。（C）2010年，JPO＆INPIT

公开(公告)号：JP2014199206A

公开(公告)日：2014-10-23

申请号：JP2013074628

申请日：2013-03-29

Applicant: ソニー株式会社 ,  Sony Corp

Inventor： SAKAMOTO NAOHISA ,  MATSUMOTO MASAHIRO ,  WATANABE HIDETOSHI ,  ONISHI MICHIHIRO ,  KATO YOSHIAKI ,  WATANABE TOSHIO

IPC: G01N35/08 ,  B01J19/00 ,  B81B1/00 ,  G01N37/00

CPC classification number: G01N27/447 ,  G01N30/6095 ,  G01N2030/8827

Abstract: 【課題】液体の充填が完了する時間のばらつきを抑制可能なマイクロチップの提供。【解決手段】液体が注入される導入部と、前記液体が供給される複数の分析領域と、前記液体が前記導入部から前記複数の分析領域のそれぞれに同じタイミングで供給されるように形成された流路と、を備えるマイクロチップを提供する。このマイクロチップでは、導入部に液体が注入されると、その液体が流路を通流し、複数の分析領域のそれぞれに同じタイミングで到達する。【選択図】図1

Abstract translation: 要解决的问题：提供一种能够抑制液体填充完成时间的波动的微芯片。解决方案：提供一种微芯片，包括：注入液体的入口部分; 供给液体的多个分析区域; 以及流路，其形成为在与所述入口部相同的时刻将液体供给到所述多个分析区域中的每一个。 在微芯片中，当向入口部注入液体时，液体流过流路并以相同的时刻到达各个分析区域。

公开(公告)号：JP2014011974A

公开(公告)日：2014-01-23

申请号：JP2012150711

申请日：2012-07-04

Applicant: Sony Corp ,  ソニー株式会社

Inventor： MATSUMOTO MASAHIRO ,  NAKAMURA TOMOHIKO

IPC: C12M1/00 ,  B01J19/00 ,  G01N35/02 ,  G01N35/08 ,  G01N37/00

CPC classification number: B01L3/5027 ,  B01L2200/16 ,  B01L2300/0816 ,  B01L2300/0864 ,  G01N33/54366 ,  Y10T29/49124

Abstract: PROBLEM TO BE SOLVED: To provide a microchip for chemical reaction which facilitates identification of the reagent composition of a solid-phase reagent contained therein, and a method for manufacturing the same.SOLUTION: There are provided a microchip for chemical reaction which contains a solid-phase reagent whose reagent composition can be identified based on appearance; and a method for manufacturing the microchip for chemical reaction, including containing a solid-phase reagent whose reagent composition can be identified based on appearance. Consequently, it is possible to facilitate identification of the reagent composition of a solid-phase reagent contained in a well of the microchip.

Abstract translation: 要解决的问题：提供一种用于化学反应的微芯片，其有助于鉴定其中所含的固相试剂的试剂组合物及其制造方法。解决方案：提供一种用于化学反应的微芯片，其包含固体 试剂组成可以根据外观鉴定; 以及用于制造用于化学反应的微芯片的方法，包括含有根据外观可以鉴定其试剂组成的固相试剂。 因此，可以方便地识别包含在微芯片的阱中的固相试剂的试剂组合物。