公开(公告)号：WO2007030545A3

公开(公告)日：2007-11-08

申请号：PCT/US2006034722

申请日：2006-09-06

Applicant: SOUTHWEST RES INST ,  SLOVIN ELIOT M ,  PERSYN JOSEPH T ,  MCDONOUGH JOSEPH A ,  VAIL NEAL K ,  BARLOW DARREN E ,  ZWIENER ALBERT M

Inventor： SLOVIN ELIOT M ,  PERSYN JOSEPH T ,  MCDONOUGH JOSEPH A ,  VAIL NEAL K ,  BARLOW DARREN E ,  ZWIENER ALBERT M

IPC: A61K47/00 ,  A61K47/30 ,  A61K47/32

CPC classification number: A61K9/5031 ,  A61K9/0048 ,  A61K9/1647

Abstract: This invention is directed to an apparatus and method for producing microparticles comprising pharmacologically active agents and biodegradable polymers. The apparatus (100) includes a spinning disk (105) containing a reservoir (708) in the center thereof and a flat inclined surface. The apparatus optionally includes serrations (712) and/or a flat surface beneath the periphery of the disk that is parallel to the rotational axis of the disk. The invention is also directed to a method for producing microparticles containing pharmacologically active agents, using the spinning disk apparatus. Formulations containing ophthalmically active agents are provided. Formulations exhibiting zero order release rates are also described.

Abstract translation: 本发明涉及一种用于生产包含药理活性剂和可生物降解聚合物的微粒的装置和方法。 设备（100）包括在其中心包含储存器（708）的旋转盘（105）和平坦的倾斜表面。 该装置可选地包括锯齿（712）和/或平行于盘的旋转轴线的圆周周围的平坦表面。 本发明还涉及使用旋转圆盘装置的含有药理活性剂的微粒的制造方法。 提供含有眼科活性剂的制剂。 还描述了显示零级释放速率的制剂。

公开(公告)号：WO9852412A8

公开(公告)日：1999-04-15

申请号：PCT/US9808387

申请日：1998-04-24

Applicant: BERNARD TECHNOLOGIES INC ,  SOUTHWEST RES INST

Inventor： WELLINGHOFF STEPHEN T ,  BARENBERG SUMNER A ,  KAMPA JOEL J ,  BARLOW DARREN E

IPC: A61L2/16 ,  A01N25/04 ,  A01N25/10 ,  A01N25/12 ,  A01N59/00 ,  A01N59/02 ,  A23B9/14 ,  A23B9/30 ,  A61L2/20 ,  C01B11/02 ,  C07F9/6596 ,  C09K17/00 ,  A01N25/02 ,  A01N25/08 ,  A01N25/18 ,  A01N25/34 ,  A61K47/32

CPC classification number: C07F9/6596 ,  A01N59/00 ,  A01N59/02 ,  A23B9/14 ,  A23B9/30 ,  A61L2/20 ,  C01B11/022 ,  C01B11/024 ,  Y02A50/359 ,  A01N25/34 ,  A01N25/24 ,  A01N25/18 ,  A01N2300/00

Abstract: A composite for retarding microbiological contamination containing a hydrophobic material containing an acid releasing agent, and a hydrophilic material containing anions that are capable of reacting with hydronium ions to generate gas. The hydrophilic and hydrophobic materials are adjacent and substantially free of water, and the hydrophilic material is capable of generating and releasing the gas after hydrolysis of the acid releasing agent.

Abstract translation: 用于延缓含有含有脱酸剂的疏水性材料的微生物污染的复合材料，以及含有能够与水合氢离子反应产生气体的阴离子的亲水材料。 亲水和疏水材料相邻且基本上不含水，并且亲水材料能够在脱酸剂水解后产生和释放气体。

公开(公告)号：EP1931387A4

公开(公告)日：2012-07-11

申请号：EP06803043

申请日：2006-09-06

Applicant: SOUTHWEST RES INST ,  SLOVIN ELIOT M

Inventor： SLOVIN ELIOT M ,  PERSYN JOSEPH T ,  MCDONOUGH JOSEPH A ,  VAIL NEAL K ,  BARLOW DARREN E ,  ZWIENER ALBERT M

IPC: A61K47/00 ,  A61K9/00 ,  A61K9/16 ,  A61K9/52 ,  A61K47/30 ,  A61K47/32

CPC classification number: A61K9/5031 ,  A61K9/0048 ,  A61K9/1647

公开(公告)号：EP0982986A4

公开(公告)日：2003-08-13

申请号：EP98918754

申请日：1998-04-24

Applicant: BERNARD TECHNOLOGIES INC ,  SOUTHWEST RES INST

Inventor： WELLINGHOFF STEPHEN T ,  BARENBERG SUMNER A ,  KAMPA JOEL J ,  BARLOW DARREN E

IPC: A61L2/16 ,  A01N25/04 ,  A01N25/10 ,  A01N25/12 ,  A01N59/00 ,  A01N59/02 ,  A23B9/14 ,  A23B9/30 ,  A61L2/20 ,  C01B11/02 ,  C07F9/6596 ,  C09K17/00 ,  A01N25/02 ,  A01N25/08 ,  A01N25/18 ,  A01N25/34 ,  A61K47/32

CPC classification number: C07F9/6596 ,  A01N59/00 ,  A01N59/02 ,  A23B9/14 ,  A23B9/30 ,  A61L2/20 ,  C01B11/022 ,  C01B11/024 ,  Y02A50/359 ,  A01N25/34 ,  A01N25/24 ,  A01N25/18 ,  A01N2300/00

Abstract: A composite for retarding microbiological contamination containing a hydrophobic material containing an acid releasing agent, and a hydrophilic material containing anions that are capable of reacting with hydronium ions to generate a gas. The hydrophilic and hydrophobic materials are adjacent and substantially free of water, and the hydrophilic material is capable of generating and releasing the gas after hydrolysis of the acid releasing agent.

公开(公告)号：EP0776269A4

公开(公告)日：2000-08-09

申请号：EP96918038

申请日：1996-06-04

Applicant: SOUTHWEST RES INST

Inventor： WELLINGHOFF STEPHEN T ,  KAMPA JOEL J ,  BARLOW DARREN E

IPC: A23L3/3445 ,  A01N59/00 ,  A01N59/08 ,  A23B9/14 ,  A23B9/30 ,  A23L3/358 ,  A61L2/16 ,  A61L2/20 ,  B01D39/14 ,  B05D1/24 ,  C01B11/00 ,  C01B11/02 ,  C08J3/12 ,  B32B5/16 ,  B05D1/08 ,  B05D7/00 ,  B32B9/04 ,  B32B27/00 ,  B32B27/18 ,  B32B27/32 ,  B32B27/36

CPC classification number: C01B11/024 ,  A01N59/00 ,  A23B9/14 ,  A23B9/30 ,  C01B11/022 ,  Y10T428/2991 ,  Y10T428/2998 ,  A01N25/26 ,  A01N25/12 ,  A01N2300/00

Abstract: A biocidal powder for sustained release of chlorine dioxide includes particles containing chlorite anions, and a hydrophobic core having the particles on a surface thereof, the hydrophobic core containing an acid releasing agent. The particles and the hydrophobic core are substantially free of water, and the particles are capable of releasing chlorine dioxide upon hydrolysis of the acid releasing agent.

公开(公告)号：AU697974B2

公开(公告)日：1998-10-22

申请号：AU6039796

申请日：1996-06-04

Applicant: SOUTHWEST RES INST

Inventor： WELLINGHOFF STEPHEN T ,  KAMPA JOEL J ,  BARLOW DARREN E

IPC: A23L3/3445 ,  A01N59/00 ,  A01N59/08 ,  A23B9/14 ,  A23B9/30 ,  A23L3/358 ,  A61L2/16 ,  A61L2/20 ,  B01D39/14 ,  B05D1/24 ,  C01B11/00 ,  C01B11/02 ,  C08J3/12 ,  B32B5/16 ,  B32B9/04 ,  B32B27/00 ,  B32B27/18 ,  B32B27/32 ,  B32B27/36 ,  B05D1/08 ,  B05D7/00 ,  A01N25/26

Abstract: A biocidal powder for sustained release of chlorine dioxide includes particles containing chlorite anions, and a hydrophobic core having the particles on a surface thereof, the hydrophobic core containing an acid releasing agent. The particles and the hydrophobic core are substantially free of water, and the particles are capable of releasing chlorine dioxide upon hydrolysis of the acid releasing agent.

公开(公告)号：AU717604B2

公开(公告)日：2000-03-30

申请号：AU6363798

申请日：1998-04-28

Applicant: BERNARD TECHNOLOGIES INC ,  SOUTHWEST RES INST

Inventor： WELLINGHOFF STEPHEN T ,  BARENBERG SUMNER A ,  KAMPA JOEL J ,  BARLOW DARREN E

IPC: A61L2/16 ,  A01N25/04 ,  A01N25/10 ,  A01N25/12 ,  A01N59/00 ,  A01N59/02 ,  A23B9/14 ,  A23B9/30 ,  A61L2/20 ,  C01B11/02 ,  C07F9/6596 ,  C09K17/00 ,  A01N25/18 ,  A01N59/24

Abstract: A composite for retarding microbiological contamination containing a hydrophobic material containing an acid releasing agent, and a hydrophilic material containing anions that are capable of reacting with hydronium ions to generate a gas. The hydrophilic and hydrophobic materials are adjacent and substantially free of water, and the hydrophilic material is capable of generating and releasing the gas after hydrolysis of the acid releasing agent.

公开(公告)号：AU6363798A

公开(公告)日：1998-11-19

申请号：AU6363798

申请日：1998-04-28

Applicant: BERNARD TECHNOLOGIES INC ,  SOUTHWEST RES INST

Inventor： WELLINGHOFF STEPHEN T ,  BARENBERG SUMNER A ,  KAMPA JOEL J ,  BARLOW DARREN E

IPC: A61L2/16 ,  A01N25/04 ,  A01N25/10 ,  A01N25/12 ,  A01N59/00 ,  A01N59/02 ,  A23B9/14 ,  A23B9/30 ,  A61L2/20 ,  C01B11/02 ,  C07F9/6596 ,  C09K17/00 ,  A01N25/18 ,  A01N59/24

Abstract: A composite for retarding microbiological contamination containing a hydrophobic material containing an acid releasing agent, and a hydrophilic material containing anions that are capable of reacting with hydronium ions to generate a gas. The hydrophilic and hydrophobic materials are adjacent and substantially free of water, and the hydrophilic material is capable of generating and releasing the gas after hydrolysis of the acid releasing agent.

公开(公告)号：CA2196777A1

公开(公告)日：1996-12-12

申请号：CA2196777

申请日：1996-06-04

Applicant: SOUTHWEST RES INST

Inventor： WELLINGHOFF STEPHEN T ,  KAMPA JOEL J ,  BARLOW DARREN E

IPC: A23L3/3445 ,  A01N59/00 ,  A01N59/08 ,  A23B9/14 ,  A23B9/30 ,  A23L3/358 ,  A61L2/16 ,  A61L2/20 ,  B01D39/14 ,  B05D1/24 ,  C01B11/00 ,  C01B11/02 ,  C08J3/12 ,  A01N25/14

Abstract: A biocidal powder for sustained release of chlorine dioxide includes particles containing chlorite anions, and a hydrophobic core having the particles on a surface thereof, the hydrophobic core containing an acid releasing agent. The particles and the hydrophobic core are substantially free of water, and the particles are capable of releasing chlorine dioxide upon hydrolysis of the acid releasing agent.

公开(公告)号：NZ310072A

公开(公告)日：1998-11-25

申请号：NZ31007296

申请日：1996-06-04

Applicant: SOUTHWEST RES INST

Inventor： WELLINGHOFF STEPHEN T ,  KAMPA JOEL J ,  BARLOW DARREN E

IPC: A01N59/00 ,  A01N59/08 ,  A23B9/14 ,  A23B9/30 ,  A23L3/358 ,  A61L2/16 ,  A61L2/20 ,  B01D39/14 ,  A23L3/3445 ,  B05D1/24 ,  C01B11/00 ,  C01B11/02 ,  C08J3/12 ,  A01N25/22 ,  A01N25/24 ,  B32B5/16 ,  B32B9/04 ,  B32B27/00 ,  B32B27/18 ,  B32B27/32

Abstract: A biocidal powder for sustained release of chlorine dioxide includes particles containing chlorite anions, and a hydrophobic core having the particles on a surface thereof, the hydrophobic core containing an acid releasing agent. The particles and the hydrophobic core are substantially free of water, and the particles are capable of releasing chlorine dioxide upon hydrolysis of the acid releasing agent.