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公开(公告)号：US20170138939A1
公开(公告)日：2017-05-18
申请号：US15319717
申请日：2015-06-19
Applicant: SPINCHIP DIAGNOSTICS AS
Inventor： Stig Morten BORCH , Torgeir HAMSUND , Jostein Geir HOLTLUND , Anja GULLIKSEN
IPC: G01N33/543
CPC classification number: G01N1/10 , B01L3/502753 , B01L3/502761 , B01L2200/0647 , B01L2200/10 , B01L2400/0409 , B01L2400/0487 , B03D3/00 , G01N33/54313 , G01N33/54333 , G01N33/54366 , G01N2001/1006 , G01N2035/0449
Abstract: The present invention provides a method of transferring beads in a fluidic chip comprising an internal fluid circuit through which various reactants, in which at least one of the reactants are beads, may be moved by use of centrifugal force, the method comprises the steps of: providing beads (8) having a density equal to, or lower than, m1 in a section (7, 15) of the fluid circuit, the section comprising at least a first outlet (16, 13); providing a first liquid medium to the section, the liquid medium having a density d2, such that d2>m1; and applying a centrifugal force such that the beads migrate in the opposite direction of the centrifugal force.
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公开(公告)号：US20170138938A1
公开(公告)日：2017-05-18
申请号：US15319712
申请日：2015-06-19
Applicant: SpinChip Diagnostics AS
Inventor： Stig Morten BORCH , Torgeir HAMSUND , Jostein Geir HOLTLUND , Anja GULLIKSEN
IPC: G01N33/543
CPC classification number: G01N1/10 , B01L3/502753 , B01L3/502761 , B01L2200/0647 , B01L2200/10 , B01L2400/0409 , B01L2400/0487 , B03D3/00 , G01N33/54313 , G01N33/54333 , G01N33/54366 , G01N2001/1006 , G01N2035/0449
Abstract: The present invention provides a method of analyzing a sample containing an analyte to be qualitatively and/or quantitatively determined, comprising a binding step and a washing step, wherein the binding step comprises: interacting the analyte with beads having a density m1; obtaining a structure of packed beads comprising quantifiable bead complexes having a density m2; and the washing step comprises: dispersing the packed beads in a liquid medium having a density d>m2 and m1; and separating the liquid medium and the beads comprising the quantifiable bead complexes.
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公开(公告)号：US20170138823A1
公开(公告)日：2017-05-18
申请号：US15319723
申请日：2015-06-19
Applicant: SpinChip Diagnostics AS
Inventor： Stig Morten BORCH , Torgeir HAMSUND , Jostein Geir HOLTLUND , Anja GULLIKSEN
CPC classification number: G01N1/10 , B01L3/502753 , B01L3/502761 , B01L2200/0647 , B01L2200/10 , B01L2400/0409 , B01L2400/0487 , B03D3/00 , G01N33/54313 , G01N33/54333 , G01N33/54366 , G01N2001/1006 , G01N2035/0449
Abstract: The present invention provides a method of separating beads in a fluidic chip comprising an internal fluid circuit through which various reactants, in which at least one of the reactants are beads, may be moved by use of centrifugal force, the method comprises the steps of: providing at least a first set of beads (8a) having a density m1 and a second set of beads (8b) having a density m2 in a section (7, 15, 18) of the fluid circuit, the section comprising at least a first outlet (16, 13, 17); providing a first liquid medium in the section, the liquid medium having a density d3, such that m1
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