公开(公告)号：WO9416487A3

公开(公告)日：1994-09-01

申请号：PCT/US9309691

申请日：1993-10-07

Applicant: SPIRE CORP

Inventor： BUCHANAN BOBBY L ,  BURKE EDWARD A ,  LITTLE ROGER G

IPC: G21H1/06 ,  H01L23/58 ,  H02J

CPC classification number: G21H1/06 ,  G21Y2002/301 ,  G21Y2004/101 ,  G21Y2004/305 ,  H01L23/58 ,  H01L2924/0002 ,  H01L2924/3011 ,  H01L2924/00

Abstract: A microprocessing module (100) is powered by radio-nuclide voltaic-junction batteries (114). The microelectronics circuitry (104) includes a clock circuit unit (120), a central processing unit with an arithmetic logic unit (122), a read only memory (124), and a random access memory (126). The input/output circuitry includes a serial input/output interface (128), a parallel input/output interface (130), and a priority interrupt controller (132). The microprocessor module (100) also has a control bus (108) and a data bus (106).

公开(公告)号：WO2004051241A3

公开(公告)日：2004-09-10

申请号：PCT/US0337571

申请日：2003-11-24

Applicant: SPIRE CORP

Inventor： LITTLE ROGER G ,  LINDEN KURT J

IPC: G01N21/64 ,  G01N21/77

CPC classification number: G01N21/6454 ,  G01N2021/6469 ,  G01N2201/0407 ,  G01N2201/0612

Abstract: The present invention provides a microarray having a plurality of micro-locations for confining selected photophores, for example, biological molecules exhibiting fluorescence spectra. The microarray can further include an array of optoelectronic photodetectors each of which is optically coupled with at least one of the micro-locations to detect radiation, for example, fluorescence radiation, that is emitted from the photophores confined in that micro-location. Each photodetector includes a resonant cavity that is formed of a front reflector and/or a back reflector having distributed Bragg reflector structures and a photo-detecting element disposed in the resonant cavity. The microarray can utilize either external optical excitation sources, such as lasers, LEDs, or can contain its own excitation sources in an integrated structure containing both optical radiation emitters, such as, vertical cavity surface emitting lasers or resonant cavity LEDs, and resonant cavity photodetectors. The integrated emitters and detectors can be either coaxially or adjacently located. Further, the microarray can include either separate sample array and excitation/detector array plates, or a single sample/excitation/detector array plate in which the photophore-containing sample molecules can be deposited directly on the excitation/detector array.

Abstract translation: 本发明提供一种微阵列，其具有用于限制所选择的光致抗体的多个微位置，例如表现出荧光光谱的生物分子。 微阵列还可以包括光电子检测器阵列，每个光电检测器与至少一个微位置光学耦合，以检测从限制在该微位置的光电子发射的辐射，例如荧光辐射。 每个光电检测器包括谐振腔，其由具有分布式布拉格反射器结构的前反射器和/或后反射器形成，以及设置在谐振腔中的光检测元件。 微阵列可以利用诸如激光器，LED的外部光学激发源，或者可以在包含光辐射发射器（诸如垂直腔表面发射激光器或谐振腔LED）的集成结构中包含其自身的激发源，以及谐振腔光电探测器 。 集成的发射器和检测器可以同轴或相邻地定位。 此外，微阵列可以包括单独的样品阵列和激发/检测器阵列板，或者单个样品/激发/检测器阵列板，其中含光致抗体的样品分子可以直接沉积在激发/检测器阵列上。

公开(公告)号：AU2003226042A8

公开(公告)日：2003-10-27

申请号：AU2003226042

申请日：2003-04-10

Applicant: SPIRE CORP

Inventor： LITTLE ROGER G

IPC: B01J19/00 ,  C40B40/06 ,  C40B60/14 ,  C12Q1/68 ,  G01N33/543

Abstract: The present invention provides substrates having a plurality of micro-locations on its surface. Each micro-location has an effective dose of an ion beam treatment such that the plurality of the micro-locations exhibit an affinity to a compound that is different from the affinity of the remainder of the substrate surface to that compound. The substrates of the invention can be utilized to form microarrays of biological molecules, such as oligonucleotides or peptides. Such microarrays can find a variety of applications. For example, they can be employed in large scale hybridization assays in many genetic applications, such as mapping of genomes, monitoring of gene expression, DNA sequencing, genetic diagnosis, and genotyping of organisms.

公开(公告)号：AU2003294509A1

公开(公告)日：2004-06-23

申请号：AU2003294509

申请日：2003-11-24

Applicant: SPIRE CORP

Inventor： LITTLE ROGER G ,  LINDEN KURT J

IPC: G01N21/64 ,  G01N21/77

Abstract: The present invention provides a microarray having a plurality of micro-locations for confining selected photophores, for example, biological molecules exhibiting fluorescence spectra. The microarray can further include an array of optoelectronic photodetectors each of which is optically coupled with at least one of the micro-locations to detect radiation, for example, fluorescence radiation, that is emitted from the photophores confined in that micro-location. Each photodetector includes a resonant cavity that is formed of a front reflector and/or a back reflector having distributed Bragg reflector structures and a photo-detecting element disposed in the resonant cavity. The microarray can utilize either external optical excitation sources, such as lasers, LEDs, or can contain its own excitation sources in an integrated structure containing both optical radiation emitters, such as, vertical cavity surface emitting lasers or resonant cavity LEDs, and resonant cavity photodetectors. The integrated emitters and detectors can be either coaxially or adjacently located. Further, the microarray can include either separate sample array and excitation/detector array plates, or a single sample/excitation/detector array plate in which the photophore-containing sample molecules can be deposited directly on the excitation/detector array.

公开(公告)号：AU2003226042A1

公开(公告)日：2003-10-27

申请号：AU2003226042

申请日：2003-04-10

Applicant: SPIRE CORP

Inventor： LITTLE ROGER G

IPC: B01J19/00 ,  C40B40/06 ,  C40B60/14

Abstract: The present invention provides substrates having a plurality of micro-locations on its surface. Each micro-location has an effective dose of an ion beam treatment such that the plurality of the micro-locations exhibit an affinity to a compound that is different from the affinity of the remainder of the substrate surface to that compound. The substrates of the invention can be utilized to form microarrays of biological molecules, such as oligonucleotides or peptides. Such microarrays can find a variety of applications. For example, they can be employed in large scale hybridization assays in many genetic applications, such as mapping of genomes, monitoring of gene expression, DNA sequencing, genetic diagnosis, and genotyping of organisms.