公开(公告)号：CA2017137A1

公开(公告)日：1990-11-22

申请号：CA2017137

申请日：1990-05-18

Applicant: STAMICARBON ,  TOSOH CORP

Inventor： IRINO SHIGEAKI ,  WAKAMATSU HIDETOSHI ,  KUNISAWA YUKIO ,  STOELWINDER CHRISTIAAN J C ,  TOUSSAINT ANTOON G T

IPC: C07K1/14 ,  C07K1/30 ,  C07K5/072 ,  C07K5/075 ,  C07K5/06

Abstract: - 14 - (14) AE 6335 A method for crystallizing .alpha.-L-aspartyl-L-phenyl-alanine methyl ester, which comprises mixing a hot aqueous solution containing .alpha.-L-aspartyl-L-phenylalanine methyl ester and a cold aqueous solution which may contain .alpha.-L-aspartyl-L-phenylalanine methyl ester, in such proportions that the concentration of .alpha.-L-aspartyl-L-phenylalanine methyl ester after mixing exceeds its solubility in the mixture of the two aqueous solutions at the temperature of the mixture, to precipitate crystals of .alpha.-L-aspartyl-L-phenylalanine methyl ester, and if necessary, cooling the mixture, the total amount of .alpha.-L-aspartyl-L-phenylalanine methyl ester contained in the hot and cold aqueous solutions being such that when the two aqueous solutions are mixed to precipitate crystals of .alpha.-L-aspartyl-L-phenylalanine methyl ester, it exceeds the solubility level of .alpha.-L-aspartyl-L-phenylalanine methyl ester in the mixture of the two aqueous solutions at the temperature of the mixture.